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免疫チェックポイント タンパク質

Immune Checkpoint Proteins
バックグラウンド

免疫チェックポイント(immune checkpoint)は免疫システムにおける重要な調節因子です。免疫チェックポイントを用いて開発されている抗体医薬品は重要な免疫療法剤として、がん、がん、免疫疾患などの治療に使われています。CTLA-4とPD-1/PD-L1は現在最も研究されている抑制受容体で、免疫チェックポイントを抑制し、がんを治療します。LAG-3、TIM-3、TIGIT、VISTA、B7-H3などの免疫チェックポイント受容体抗体薬の開発が研究で進んでいます。また、GITR、4-1BB、CD40などの活性化受容体を使った分子標的薬の研究も始められています。このように、免疫チェックポイント抗体薬の開発を効率的に行うことが非常に重要です。

免疫チェックポイントタンパク質が適用されている医薬品創薬をご確認ください。

免疫チェックポイントの経路
CD155 ICOSL CD86 CD80 MHC CD40 PD-L2 PD-L1 4-1BBL OX40L GITRL MHC PD-L1 Galectin 9 TIGIT ICOS CTLA-4 CD28 TCR CD40L PD-1 PD-1 4-1BB OX40 GITR TCR PD-1 TIM-3 TCR PD-1 PD-1 LAG-3 MHC PD-L1 PD-L2 MHC-LL Dendritic cell Tumor cell Macrophage T-cells

分子名をクリックし詳細情報をご確認ください。

Stimulatory signal

Inhibitory signal

ほかの免疫チェックポイントタンパク質についてはこちら

製品特長&用途
製品の特徴:
高い純度がMALS/HPLCの検証によって、高い生物活性はELISA/SPR/FACSなどの検証によって確認された。厳しいQCによって、高いバッチ間一貫性を保証できます。
製品の用途
製品リスト

分子名をクリックし詳しい情報を確認

  • 免疫共抑制分子
  • 免疫共刺激分子

  • ほかの免疫チェックポイント分子一覧
  • 阻害剤スクリーニングキット製品リスト
分子名 種族 タグ 標識 検証データ
(プロトコルを提供可能)
PD-1 Human, Mouse, Canine, Cynomolgus, Rabbit, Rat, Rhesus macaque Fc, His, Fc & His, Fc & Avi & His, Fc & Avi, His & Avi, mFc& Avi, Twin-Strep, Llama Fc , mFc Biotin-labeled, PE-labeled, Unconjugated SDS-PAGE, MALS, HPLC, ELISA, BLI, SPR, FACS
PD-L1 Human, Mouse, Rabbit, Canine, Cynomolgus / Rhesus macaque Fc, His, Fc & Avi, His & Avi, Fc & Avi & His, mFc, LlamaFc, mFc& Avi, Twin-Strep Biotin-labeled, Unconjugated SDS-PAGE, MALS, ELISA, BLI, SPR, FACS
PD-L2 Human, Mouse Fc, His, Fc & Avi, Avi & His, mFc Biotin-labeled, Unconjugated SDS-PAGE, HPLC, ELISA, SPR, BLI, FACS, Cell based assay
B7-H3 Human, Mouse, Cynomolgus Fc & Avi, Avi & His, His, Fc, Avi & His Biotin-labeled, Unconjugated SDS-PAGE, MALS, ELISA, Cell based assay
B7-H4 Human, Mouse His, Fc Biotin-labeled, Unconjugated SDS-PAGE, ELISA
B7-H5 Human, Mouse, Rhesus macaque Fc & Avi, Avi & His, His, Fc, mFc Biotin-labeled, Unconjugated SDS-PAGE, MALS, ELISA, SPR, BLI
BTLA Human, Mouse Fc & Avi, His & Avi, His, mFc, Fc Biotin-labeled, Unconjugated SDS-PAGE, ELISA
CD80(B7-1) Human, Mouse, Cynomolgus / Rhesus macaque Fc, Fc & Avi, Avi & His, mFc, His Biotin-labeled, Unconjugated SDS-PAGE, MALS, HPLC, ELISA, SPR, BLI, FACS
CD86(B7-2) Human, Mouse, Cynomolgus / Rhesus macaque Fc & Avi, Fc, His Biotin-labeled, Unconjugated SDS-PAGE, MALS, HPLC, ELISA, BLI, FACS
CD96 Human His & Avi, His, mFc Biotin-labeled, Unconjugated SDS-PAGE, MALS, ELISA, BLI, FACS
CD47 Human, Mouse, Rabbit, Rat, Cynomolgus / Rhesus macaque, Canine Fc, His, Fc & Avi, His & Avi, mFc, mFc & Avi, LlamaFc Biotin-labeled, FITC-labeled, Unconjugated SDS-PAGE, MALS, ELISA, SPR, BLI, FACS
CD155 Human, Mouse, Rhesus macaque Fc & Avi, His & Avi, mFc, Fc, His Biotin-labeled, Unconjugated SDS-PAGE, MALS, ELISA, BLI, FACS
CTLA-4 Human, Mouse, Rabbit, Rat, Cynomolgus / Rhesus macaque Fc, His, Fc & Avi, His & Avi, mFc, mFc& Avi Biotin-labeled, Unconjugated SDS-PAGE, MALS, ELISA, SPR, BLI, FACS
LAG-3 Human, Mouse, Rat, Cynomolgus, Marmoset Fc, His, Fc & Avi, His & Avi, mFc, mFc & Avi, LlamaFc Biotin-labeled, Unconjugated SDS-PAGE, MALS, ELISA, SPR, BLI, FACS
TIGIT Human, Mouse, Rabbit, Rat, Cynomolgus / Rhesus macaque, Canine mFc& Avi, Fc & Avi, His & Avi, His, Fc, mFc Biotin-labeled, Unconjugated SDS-PAGE, MALS, HPLC, ELISA, SPR, BLI
TIM-3 Human, Mouse, Cynomolgus Avi & His, mFc, Fc, His Biotin-labeled, Unconjugated SDS-PAGE, MALS, ELISA, SPR
CD111 Human His, Fc Unconjugated SDS-PAGE, ELISA, BLI
DNAM-1 Human, Cynomolgus Fc & Avi, His, Fc Biotin-labeled, Unconjugated SDS-PAGE, ELISA, BLI, FACS
Galectin-9 Human His, MBP & His Unconjugated SDS-PAGE
HVEM Human His, Twin-Strep, Fc, mFc, Fc & Avi Biotin-labeled, Unconjugated , SDS-PAGE, ELISA, BLI
Nectin-2 Human His, Fc Biotin-labeled, Unconjugated SDS-PAGE, HPLC, ELISA, BLI
Nectin-3 Human His, Fc Biotin-labeled, Unconjugated SDS-PAGE, MALS, ELISA, BLI
PVRIG Human, Mouse, Cynomolgus Fc & Avi, mFc& Avi, His & Avi, His, mFc Biotin-labeled, Unconjugated SDS-PAGE, MALS, ELISA, BLI
SIRP alpha Human, Mouse, Cynomolgus Fc, His & Avi, mFc& Avi, mFc, His Biotin-labeled, PE-labeled, Unconjugated SDS-PAGE, MALS, HPLC, ELISA, BLI, FACS
SIRP alpha V2 Human His Biotin-labeled, Unconjugated SDS-PAGE, ELISA
SIRP gamma Human Fc Unconjugated SDS-PAGE, ELISA
CD160 Human His Unconjugated SDS-PAGE, ELISA
分子名 種族 タグ 標識 検証データ
(プロトコルを提供可能)
4-1BB Ligand Human, Mouse, Rat, Cynomolgus Fc, Fc & Avi, mFc, His & Flag Biotin-labeled, Unconjugated SDS-PAGE, MALS, ELISA, BLI, Cell based assay
4-1BB Human, Mouse, Rat, Rabbit, Cynomolgus / Rhesus macaque, Canine His, Fc, Fc & Avi, His & Avi, mFc Biotin-labeled, Unconjugated SDS-PAGE, MALS, ELISA, SPR
OX40 Ligand Human, Mouse, Rhesus macaque Fc, His, His & Avi, Avi & Fc, mFc Biotin-labeled, Unconjugated SDS-PAGE, MALS, ELISA, BLI, FACS
OX40 Human, Mouse, Rabbit, Rat, Rhesus macaque, Marmoset His, Fc, His & Avi, Fc & Avi, Avi & His, mFc Biotin-labeled, Unconjugated SDS-PAGE, MALS, ELISA, BLI, FACS
ICOS Ligand
(B7-H2)
Human, Mouse, Cynomolgus His, Fc Unconjugated SDS-PAGE, ELISA
ICOS Human, Mouse, Cynomolgus His, Fc, His & Avi Biotin-labeled, Unconjugated SDS-PAGE, ELISA
GITR Ligand Human, Mouse His, Fc, Avi & Fc Biotin-labeled, Unconjugated SDS-PAGE, ELISA
GITR Human, Mouse, Rat, Rhesus macaque, Canine His, Fc, His & Avi, Fc & Avi, mFc Biotin-labeled, Unconjugated SDS-PAGE, MALS, ELISA
CD48 Human His, Fc, mFc Unconjugated SDS-PAGE, ELISA
HVEM Human His, Fc, Fc & Avi, mFc, TwiStrep Biotin-labeled, Unconjugated SDS-PAGE, MALS, BLI
Nectin-2 Human His, Fc, Fc & Avi, mFc Biotin-labeled, Unconjugated SDS-PAGE, MALS, HPLC, ELISA, BLI
CD40 Ligand Human, Mouse, Human / Rhesus macaque His, Fc, His & Avi, Avi & Fc, Avi & His & Flag, His & Flag, mFc Biotin-labeled, Unconjugated SDS-PAGE, MALS, ELISA, BLI
CD40 Human, Mouse, Rabbit, Cynomolgus, Rhesus macaque His, Fc, Avi & His, Fc & Avi, mFc Biotin-labeled, Unconjugated SDS-PAGE, MALS, ELISA, BLI, FACS
CD30 ligand Human His, mFc Unconjugated SDS-PAGE, ELISA, BLI, FACS
CD30 Human His, Fc, Avi & His, LlamaFc Biotin-labeled, PE-labeled, FITC-labeled, Unconjugated SDS-PAGE, MALS, ELISA, BLI, FACS
CD28 Mouse, Human / Cynomolgus / Rhesus macaque His, Fc, His & Avi, Fc & Avi, mFc Biotin-labeled, Unconjugated SDS-PAGE, HPLC, ELISA, SPR, BLI
CD27 Ligand Human, Mouse His & Avi, mFc, His, His & Avi & Flag, His & Flag, Fc Biotin-labeled, FITC-labeled, Unconjugated SDS-PAGE, MALS, HPLC, ELISA
CD27 Human, Mouse His, Fc, Fc & Avi, mFc Biotin-labeled, Unconjugated SDS-PAGE, MALS, HPLC, ELISA
B7-1 Human, Mouse, Cynomolgus / Rhesus macaque Fc, Fc & Avi, Avi & His, mFc, His Biotin-labeled, Unconjugated SDS-PAGE, MALS, HPLC, ELISA, SPR, BLI, FACS
B7-2 Human, Mouse, Cynomolgus / Rhesus macaque His, Fc, Fc & Avi Biotin-labeled, Unconjugated SDS-PAGE, MALS, HPLC, ELISA, BLI, FACS
LIGHT Human His, mFc, Fc Unconjugated SDS-PAGE, MALS, ELISA, BLI
B7-H7 Human, Cynomolgus His, Fc, His & Avi, Fc & Avi Biotin-labeled, Unconjugated SDS-PAGE, MALS, BLI
B7-H6 Human, Cynomolgus His, His & Avi, Fc & Avi Biotin-labeled, Unconjugated SDS-PAGE, ELISA, SPR
2B4 Human His, Fc, Avi & His Biotin-labeled, Unconjugated SDS-PAGE, ELISA
CD28H Human His, Fc Unconjugated SDS-PAGE, ELISA
NKp30 Human His, Fc Unconjugated SDS-PAGE, SPR
製品番号 詳細情報 Detection mechanism 予約注文/注文
実験データ

独自の実験方法を無償で提供しております。製品のページから関連のプロトコルを申し込んでください。

真の分子量と構造はMALSで検証済みである。

CD27 Ligand, MALS-validated protein

Figure 1. The purity of Human CD27 Ligand, His,Flag Tag (active trimer) (MALS verified) (Cat. No. CDL-H52Da) is more than 95% in HP-SEC, and around 55-70 kDa verified by SEC-MALS.

ロット間の一貫性は良好である

組換えタンパク質の純度と生物活性の安定性はとても重要です。弊社が作っている全てのタンパク質の純度と生物活性は様々な検証によって確認されています。

PD-1, MALS-validated protein

Biotinylated Human PD-1 / PDCD1 Protein, Avitag™,His Tag (recommended for biopanning) (MALS verified)(Cat. No. PD1-H82E4

1免疫/抗体のスクリーニングに利用できる

抗体の結合を検証

PD-1&PD-L1 pathway

PD-1, MALS-validated protein1

Immobilized Human PD-1, His Tag (Cat. No. PD1-H5221) at 2 μg/mL (100 μL/well) can bind anti-PD-1 mab with a linear range of 0.1-3 ng/mL (Routinely tested).

PD-1&PD-L1 pathway

PD-1, MALS-validated protein2

Serial dilutions of anti-PD-1 mab were added into Human PD-1, Fc Tag, low endotoxin (Cat. No. PD1-H5257): Biotinylated Human PD-L1, Fc, Avitag, His Tag (Cat. No. PD1-H82F3) binding reactions. The half maximal inhibitory concentration (IC50) is 0.5381 μg/mL (Routinely tested).

弊社はPD1: PD-L1(Cat. No. EP-101)とCD47: SIRP alpha(Cat. No. EP-101) and CD47: SIRP alpha (Cat. No. EP-102)の阻害剤スクリーニングキットも開発しています。

阻害剤スクリーニングキットについてはこちら

抗体医薬品の親和性アッセイ

LAG-3 pathway

LAG-3, BLI-validated protein

Anti-LAG-3 MAb (Human IgG1) captured on CM5 chip via Anti-Human IgG Fc antibodies surface, can bind Human LAG-3, His Tag (Cat. No. LA3-H5222) with an affinity constant of 4.57 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

LAG-3 pathway

LAG-3, SPR-validated protein

Loaded Anti-LAG-3 MAb (Human IgG1) on AHC Biosensor, can bind Human LAG-3, His Tag (Cat. No. LA3-H5222) with an affinity constant of 7.47 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

中和抗体の検証

TIGIT pathway

TIGIT, MALS-validated protein

Serial dilutions of Human TIGIT Neutralizing antibody were added into Human TIGIT, Fc Tag (Cat. No. TIT-H5254): Biotinylated Human CD155, Fc,Avitag (Cat. No. CD5-H82F6) binding reactions. The half maximal inhibitory concentration (IC50) is 0.55834 μg/mL (Routinely tested).

CD47&SIPR α pathway(Cell-based assay)

CD47, FACS-validated protein

FACS analysis shows that the binding of Human CD47 to ACHN expressing SIRP-a was inhibited by increasing concentration of neutralizing SIRP-a antibody. The concentration of Human CD47 used is 20 μg/mL. IC50=9.334 μg/mL

2細胞機能の検証

4-1BB pathway

4-1BB Ligand, Cell-based assay validated protein

Human 4-1BB Ligand (71-254), Fc Tag, active trimer (Cat. No. 41L-H5265) induce IL-8 secretion in HT1080 human CD137 cell line. The EC50 for this effect is 0.079 μg/mL (Routinely tested).


3薬物動態分析−PK分析

CTLA-4 pathway

CTLA-4 dimer, Cell-based assay validated protein

Immobilized Human CTLA-4, His Tag, active dimer (Cat. No. CT4-H52H9) at 2 μg/mL, add increasing concentrations of CTLA-4 x OX40 Bispecific Antibody in 50% Human serum and then add Biotinylated Human OX40, Avitag, His Tag(Cat. No. TN4-H82E4) at 1 μg/mL. Detection was performed using HRP-conjugated streptavidin with sensitivity of 4 ng/mL (Intact assay, Routinely tested).

ACRO Quality

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