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Your Position: ホーム > 人工多能性幹細胞培養のための成長因子
The use of induced pluripotent stem cells (iPSCs) in research has completely changed regenerative medicine and accelerated the research process of human diseases. The unique self-renewal characteristics and gene engineering editing ability of iPSCs can generate an almost infinite number of mature differentiated cell types, including immune cells (T cells, NK cells, macrophages, etc.), neurons, pancreatic islet cells, etc.
ACROBiosystems focuses on supporting research and CMC manufacturing process related to cell therapy. With a comprehensive cell culture platform, antibody development platform, flow cytometry validation platform, and GMP quality management system, We have developed a series of CMC production process related products for iPSCs, helping customers accelerate the production process and fully supporting the development process based on iPSC therapy.
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    Culture and Expansion of iPSCs
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    Genome Editing of iPSCs
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    Induced Differentiation of iPSCs

Culture and Expansion of iPSCs

Product List

Product Features

Performance - facilitate rapid expansion of hPSC and support efficient differentiation into a diverse array of specialized cell types.

Better Adhesion - maintain good adhesion characteristics at a concentration as low as 2μg/ml.

Stemness Maintenance - no spontaneous differentiation is observed after several passages of hPSC culture.

Lot-to-Lot Consistency - produced from a stable cell line, robust purification process, stringent QC.

Ready to Scale-up Supply - cGMP-compliant facility.

Supporting large-scale clinical supply - strictly adhere to the GMP management system, support multiple national regulations, and ensure stable supply for production.

Validation Data

GMP Laminin 521 Validation Data
GMP Laminin521 Validation Data

Laminin 521 (GMP-LA5H24) effectively maintains the expansion of human iPSCs.

GMP Laminin521 Validation Data

Laminin 521 (GMP-LA5H24) could maintain the stemness of iPSC after several passages
 

GMP Laminin521 Validation Data

Normal karyotype (46, XX) was found in hiPSCs with Laminin 521(GMP-LA5H24) coating after 10 passages.

GMP FGF basic-Stemness Maintenance
GMP FGF basic-Stemness maintenance

FGF basic (GMP-FGCH17) could highly support stemness maintenance in ESC/iPSC compared to other companies.

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Genome Editing of iPSCs

Product List

Product Features

High purity, high enzyme activity, high cleavage efficiency

Possesses nuclear localization signals to enhance editing efficiency

Aseptic, ultra-low endotoxin

Produced in GMP-compliant facilities and undergoes QC testing

Validation Data

GMP FGF basic-Stemness maintenance

Different amounts of Cas9 were incubated with the same amount of excess gRNA and plasmid for 60 minutes at 37°C. When using 400-200 ng Acro Cas9, the cutting efficiency is greater than 90%. In comparison, when using a 200 ng Competitor T, the cutting efficiency is only about 50%.

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Induced Differentiation of iPSCs

  • iPSC-T Cell

    iPSC-T Cell

  • iPSC-NK Cell

    iPSC-NK Cell

  • iPSC-Neuron Cell

    iPSC-Neuron Cell

iPSC-T_Workflow

Product List

Product Features

GMP Grade DLL4, VCAM1:Eliminate the need of feeder cells in culture systems and support differentiation to T cells

Validated activity by iPSC to T cell differentiation

Production and quality control are carried out under strict GMP systems and comply with regulations from multiple countries

Comprehensive quality release verification, with 16 quality control indicators

Enhanced safety (sterile, no mycoplasma, no exogenous virus, animal free production system, and various impurities residual detection)

Pharmaceutical-grade production facility

Support for online and offline audits

Completion of FDA Drug Master File (DMF) registration

Validation Data

DLL4-Fc coated plate supports CD5+CD7+ T-cell progenitor differentiation from CD34+ HSPC
DLL4-Fc coated plate supports CD5+CD7+ T-cell progenitor differentiation from CD34+ HSPC

GMP Human DLL4 Protein, Fc Tag (GMP-DL4H28), together with SCF, TPO and other factors, could promote human CD34+CD45+ hematopoietic cells to differentiate into thymocyte (T) cell progenitors.

DLL4&VCAM-1 support CD5+CD7+ T-cell progenitor differentiation from CD34+ HSPC
DLL4&VCAM-1 support CD5+CD7+ T-cell progenitor differentiation from CD34+ HSPC

DLL4 (GMP-DL4H28) & VCAM1 (GMP-VC1H25) could highly support CD5+CD7+ T-cell progenitor differentiation from CD34+ HSPC.

iPSC-NK_Workflow

Product List

Product Features

GMP Grade DLL4, VCAM1:Eliminate the need of feeder cells in culture systems and support differentiation to NK cells

Validated activity by iPSC to NK cell differentiation

Production and quality control are carried out under strict GMP systems and comply with regulations from multiple countries

Comprehensive quality release verification, with 16 quality control indicators

Enhanced safety (sterile, no mycoplasma, no exogenous virus, animal free production system, and various impurities residual detection)

Pharmaceutical-grade production facility

Support for online and offline audits

Completion of FDA Drug Master File (DMF) registration

Validation Data

DLL4 & VCAM-1 for NK cell differentiation
DLL4 & VCAM-1 for NK cell differentiation

The combination of DLL4 (GMP-DL4H28) & VCAM1 (GMP-VC1H25) could significantly facilitate the differentiation efficiency of CD56+ CD3- NK cells.

SCF, FLT3L, IL7 for NK cell differentiation
DLL4 & VCAM-1 for NK cell differentiation

SCF(GMP-SCFH25), Flt3L(GMP-FLLH28), IL-7(GMP-L07H24) could significantly promote the HSPC differentiation to NK cells, comparable to Company P.

iPSC-Macrophage_Workflow

Product List

Product Features

GMP Grade FGF-8b: Efficiently induce the neuron progenitor cell into dopaminergic neurons differentiation

Validated activity by iPSC to neuron cell differentiation

Animal free production system and various impurities residual detection

Sterile, no mycoplasma, no exogenous virus

High batch-to-batch consistency and stability

Support for online and offline audits

Validation Data

Shh and FGF-8b for neuron progenitor cell differentiation
Shh and FGF-8b for neuron progenitor cell differentiation

FGF8b (Cat. No. GMP-FGBH16) and Shh (Cat. No. SH7-H5229) could efficiently induce the neuron progenitor cell into dopaminergic neurons differentiation, highly expressed TH1 and MAP2 in immunofluorescence staining and FACS.

Shh and Noggin for iPSC differentiation
Shh and Noggin for iPSC differentiation

Shh (Cat. No. SH7-H5229) and Noggin (Cat. No. NON-H5219) could efficiently induce the iPS cell into neuron progenitor cell differentiation, highly expressed PAX6, SOX1 and NESTIN in immunofluorescence staining and FACS.

ACRO Quality

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