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Your Position: ホーム > Protein > TrkC > TRC-H5256

Human TrkC / NTRK3 Protein, Fc Tag (MALS verified)

  • Synonym
    NT-3 growth factor receptor,GP145-TrkC,Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase
  • Source
    Human TrkC Protein, Fc Tag(TRC-H5256) is expressed from human 293 cells (HEK293). It contains AA Cys 32 - Thr 429 (Accession # Q16288-1).
    Predicted N-terminus: Cys 32
  • Molecular Characterization
    TrkC Structure

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 71.2 kDa. The protein migrates as 95-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
TrkC SDS-PAGE

Human TrkC Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
TrkC MALS images

The purity of Human TrkC Protein, Fc Tag (Cat. No. TRC-H5256) is more than 90% and the molecular weight of this protein is around 185-215 kDa verified by SEC-MALS.

Bioactivity-ELISA
 TrkC ELISA

Immobilized Human NT-3 / Neurotrophin-3 Protein at 2 μg/mL (100 μL/well) can bind Human TrkC Protein, Fc Tag (Cat. No. TRC-H5256) with a linear range of 0.3-5 ng/mL (QC tested).

  • Background
    Tropomyosin receptor kinase C (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, or TrkC tyrosine kinase is a protein that in humans is encoded by the NTRK3 gene. It belongs to the tropomyosin-related kinase (Trk) family of receptor tyrosine kinases (TrkA, TrkB, and TrkC).
    TrkC is the high affinity catalytic receptor for the neurotrophin NT-3 (neurotrophin-3). As such, TrkC mediates the multiple effects of this neurotrophic factor, which includes neuronal differentiation and survival.
  • Clinical and Translational Updates

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