ログイン 会員登録
icon_bulk_order一括注文 Acrobiosystems for English
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
phone
Your Position: ホーム > Protein > GUCY2C > GUC-C52H6

Cynomolgus GUCY2C / Guanylyl cyclase C Protein, His Tag (MALS verified)

  • シノニム
    GUCY2C,GUC2C,STAR,STA receptor,hSTAR,GC-C
  • ソース
    Cynomolgus GUCY2C, His Tag (GUC-C52H6) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Gln 430 (Accession # XP_005570270.1).
    Predicted N-terminus: Ser 24
  • 分子特性
    Online(Ser 24 - Gln 430) XP_005570270.1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 48.0 kDa. The protein migrates as 60-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • エンドトキシン
    Less than 1.0 EU per μg by the LAL method.
  • 純度

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • 成分

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • 再構成

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 保存

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Cynomolgus GUCY2C, His Tag (Cat. No. GUC-C52H6) SDS-PAGE gel

Cynomolgus GUCY2C, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

SEC-MALS
Cynomolgus GUCY2C, His Tag (Cat. No. ) MALS images

The purity of Cynomolgus GUCY2C, His Tag (Cat. No. GUC-C52H6) is more than 90% and the molecular weight of this protein is around 65-80 kDaverified by SEC-MALS.

Bioactivity-ELISA
Cynomolgus GUCY2C, His TagCynomolgus GUCY2C, His Tag (Cat. No. GUC-C52H6) ELISA bioactivity

Immobilized Cynomolgus GUCY2C, His Tag (Cat. No. GUC-C52H6) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human GUCY2C Antibody, Human IgG1 with a linear range of 0.3-6 ng/mL (QC tested).

Cynomolgus GUCY2C, His TagCynomolgus GUCY2C, His Tag (Cat. No. GUC-C52H6) ELISA bioactivity

Immobilized Monoclonal Anti-Human GUCY2C Antibody, Human IgG1 at 1 μg/mL (100 μL/well) can bind Cynomolgus GUCY2C, His Tag (Cat. No. GUC-C52H6) with a linear range of 3-25 ng/mL (Routinely tested).

  • バックグラウンド
    GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

コメント (0)


ETA of in-stock products: 4 business days

価格(JPY) : 98,000

価格(JPY) : 711,200

人気商品のおすすめ
抗His抗体

価格(JPY) : 67,200

価格(JPY) : 442,400

コンジュゲート HRP Anti-His 抗体

価格(JPY) : 70,000

価格(JPY) : 470,400

プロモーション&展示



医薬品開発状況

  • Number of Launched Drugs:1 Details
  • Number of Drugs in Clinical Trials:4 Details
  • Latest Research Phase:Approved

データシート&ドキュメンテーション

DMF請求
DMF (Drug Master File)

関連製品一覧

新製品

お問い合わせ&コメント

This web search service is supported by Google Inc.

totopphone