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GUCY2C

概要

Name:Heat-stable enterotoxin receptor
Target Synonym:GUC2C,Intestinal guanylate cyclase,hSTAR,EC:4.6.1.2,EC 4.6.1,GC-C,GUCY2C,Guanylate Cyclase 2C,STA Receptor,Guanylyl Cyclase C,Guanylate Cyclase 2C (Heat Stable Enterotoxin Receptor),Heat-Stable Enterotoxin Receptor,STAR,Heat Stable Enterotoxin Receptor,EC 4.6.1.2,DIAR6,MECIL,MUCIL
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Approved

ライセンス

Project Name Modality Therapeutic Area Indications Stage Right Available
Anti-GCC humanized antibody Bispecific antibody Oncology/Cancer Solid Tumor Preclinical Global

製品リスト製品比較と製品注文

製造番号 種類 製品説明 構造 純度 特徴
GUC-HF2H9 Human FITC-Labeled Human GUCY2C / Guanylyl cyclase C Protein, His TagStar Staining
GUC-HF2H9-structure
GUC-HA2H6 Human Alexa Fluor™ 555-Labeled Human GUCY2C / Guanylyl cyclase C Protein, His TagStar Staining
GUC-HA2H6-structure
GUC-HA2H4 Human APC-Labeled Human GUCY2C / Guanylyl cyclase C Protein, His Tag (Site-specific conjugation)
GUC-HA2H4-structure
GUC-M53H5 Mouse Mouse GUCY2C / Guanylyl cyclase C Protein, His Tag (MALS verified)
GUC-M53H5-structure
GUC-M53H5-sds
GUC-HA2H8 Human Alexa Fluor™ 647-Labeled Human GUCY2C / Guanylyl cyclase C Protein, His TagStar Staining
GUC-HA2H8-structure
GUC-HA2H7 Human APC-Labeled Human GUCY2C / Guanylyl cyclase C Protein, His TagStar Staining
GUC-HA2H7-structure
GUC-HP2H9 Human PE-Labeled Human GUCY2C / Guanylyl cyclase C Protein, His TagStar Staining
GUC-HP2H9-structure
GUC-HA2H5 Human Alexa Fluor™ 488-Labeled Human GUCY2C / Guanylyl cyclase C Protein, His TagStar Staining
GUC-HA2H5-structure
GUC-C82E9 Cynomolgus Biotinylated Cynomolgus GUCY2C / Guanylyl cyclase C Protein, His,Avitag™ (MALS verified)
GUC-C82E9-structure
GUC-C82E9-sds
GUC-M52E5 Mouse Biotinylated Mouse GUCY2C / Guanylyl cyclase C Protein, His,Avitag™
GUC-M52E5-structure
GUC-M52E5-sds
GUC-HF255 Human FITC-Labeled Human GUCY2C / Guanylyl cyclase C Protein, Fc Tag
GUC-HF255-structure
GUC-HF255-sds
GUC-HP2E3 Human PE-Labeled Human GUCY2C / Guanylyl cyclase C Protein, His Tag (Site-specific conjugation)
GUC-HP2E3-structure
GUC-H82E9 Human Biotinylated Human GUCY2C / Guanylyl cyclase C Protein, His,Avitag™ (MALS verified)
GUC-H82E9-structure
GUC-H82E9-sds
GUC-C5255 Cynomolgus Cynomolgus GUCY2C / Guanylyl cyclase C Protein, Fc Tag
GUC-C5255-structure
GUC-C5255-sds
GUC-C52H6 Cynomolgus Cynomolgus GUCY2C / Guanylyl cyclase C Protein, His Tag (MALS verified)
GUC-C52H6-structure
GUC-C52H6-sds
GUC-M5254 Mouse Mouse GUCY2C / Guanylyl cyclase C Protein, Fc Tag (MALS verified)
GUC-M5254-structure
GUC-M5254-sds
GUC-M52H3 Mouse Mouse GUCY2C / Guanylyl cyclase C Protein, His Tag (MALS verified)
GUC-M52H3-structure
GUC-M52H3-sds
GUC-H82F8 Human Biotinylated Human GUCY2C / Guanylyl cyclase C Protein, Fc,Avitag™
GUC-H82F8-structure
GUC-H82F8-sds
GUC-HF2H8 Human FITC-Labeled Human GUCY2C / Guanylyl cyclase C Protein, His Tag
GUC-HF2H8-structure
GUC-HF2H8-sds
GUC-H52H5 Human Human GUCY2C / Guanylyl cyclase C Protein, His Tag (MALS verified)
GUC-H52H5-structure
GUC-H52H5-sds
GUC-H5257 Human Human GUCY2C / Guanylyl cyclase C Protein, Fc Tag (MALS verified)
GUC-H5257-structure
GUC-H5257-sds
ACRO Quality

生物活性データの一部

GUC-HA2H4-Cell-based assay
 GUCY2C FACS

5e5 of anti-GUCY2C CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of APC-Labeled Human GUCY2C Protein, His Tag (Cat. No. GUC-HA2H4) and negative control protein respectively. APC signal was used to evaluate the binding activity (QC tested).

GUC-HP2E3-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

5e5 of anti-GUCY2C CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human GUCY2C, His Tag (Cat. No. GUC-HP2E3) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

GUC-HF255-ELISA
 GUCY2C ELISA

Immobilized Monoclonal Anti-Human GUCY2C Antibody, Human IgG1 at 1 μg/mL (100 μL/well) can bind FITC-Labeled Human GUCY2C, Fc Tag (Cat. No. GUC-HF255) with a linear range of 0.01-0.313 μg/mL (QC tested).

GUC-M53H5-MALS-HPLC
GUCY2C MALS images

The purity of Mouse GUCY2C Protein, His Tag (Cat. No. GUC-M53H5) is more than 90% and the molecular weight of this protein is around 75-95 kDa verified by SEC-MALS.

Synonym Name

GUCY2C,GUC2C,STAR,STA receptor,hSTAR,GC-C

Background

GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.

Clinical and Translational Updates

公開薬物情報

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Plecanatide SP-304; GCRA Approved Synergy Pharmaceuticals Inc Trulance United States Constipation; Chronic idiopathic constipation Salix Pharmaceuticals 2017-01-19 Constipation; Irritable Bowel Syndrome; Chronic idiopathic constipation Details

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
IM96 CAR-T cell Therapy IM96 Phase 1 Clinical Beijing Immunochina Medical Science & Technology Co Ltd Solid tumours; Pancreatic Neoplasms; Digestive System Neoplasms; Colorectal Neoplasms Details
PF-07062119 PF-07062119 Phase 1 Clinical Pfizer Pharmaceuticals Ltd (China) Stomach Neoplasms; Adenocarcinoma; Gastrointestinal Neoplasms; Large intestine neoplasm Details
LCAR-G08 cells therapy(Legend Biotech) LCAR-G08; (LCAR)-G08 Phase 1 Clinical Peking University, Nanjing Legend Biotechnology Co Ltd Gastrointestinal Neoplasms Details
GCC19CART GCC19CART Phase 1 Clinical Innovative Cellular Therapeutics Co Ltd Rectal Neoplasms; Colorectal Neoplasms Details
Gucy2c cart cell therapy (Innovative Cellular Therapeutics) Phase 1 Clinical Innovative Cellular Therapeutics Co Ltd Digestive System Neoplasms Details

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