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Your Position: ホーム > MHCクラスI 複合体カスタムサービス

MHCクラスI 複合体カスタムサービス

MHCクラスI 複合体カスタムサービス
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サービスの特長
カスタマイズ製品一覧
背景
MHC I（Major histocompatibility complex class I）は、ヒトではHLAとも呼ばれ、体内のすべての有核細胞に発現する多様な細胞表面受容体です。適応免疫系において重要な役割を担っています。生体内では、MHC Iは無傷のタンパク質の抗原ペプチド断片と結合することができます。このペプチド-MHC複合体は、Tリンパ球の抗原特異的受容体に認識され、活性化されたT細胞は免疫反応に寄与し、感染症の克服に貢献します。  MHC I によって表示されるペプチド は、適応免疫に不可欠な、特異性の高い T 細胞を介した応答を可能にします。このように、ペプチド-MHC I 複合体と TCR の深い関わりを研究することは、そのメカニズム解明や医薬品開発において、重要な課題となっています。
ACROBiosystemsは、生物学的薬剤の発見と開発のための主要な試薬を提供する信頼できるパートナーとして、お客様の関連研究を加速できるよう、カスタマイズされたペプチド-MHC I複合体サービスを提供します。
MHC Class I Complex Custom Service

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サービスの特長

プロフェッショナルなMHC-ペプチド複合体の研究開発技術プラットフォーム

HEK293 発現系

さまざまなMHC I と抗原が利用可能

FITC/PE/APC/ビオチン標識を選択可能

成熟した生物活性検証プラットフォーム: SPR/ELISA/FACS など

カスタマイズ製品一覧
MHCアレルターゲット
HLA-A*0101 HLA-A*0201 HLA-A*0301 HLA-A*1101 HLA-A*2402  HLA-A*3303 HLA-B*1501 HLA-B*1525 HLA-B*3802 HLA-B*4601 HLA-B*0702 
       ……		NY-ESO-1  GP-100 MSLN AFP WT1 MAGE-A1 HPV HBV HIV EBV PRAME
       ……		Customized Product List

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推奨製品
分子名製品番号動物種詳細予約・注文する
HLA-A*0301 & B2MHLM-H82W6HumanBiotinylated Human HLA-A*03:01&B2M Complex Protein (Peptide free, MALS verified)

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HLA-A*02:01 & B2MHLM-H82W3HumanBiotinylated Human HLA-A*02:01&B2M Complex Protein (Peptide free, MALS verified)

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HLA-A*11:01 & B2MHLM-H82W5HumanBiotinylated Human HLA-A*11:01&B2M Complex Protein (Peptide free, MALS verified)

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HLA-A*0201 | B2M | EWHLE-H82E4HumanBiotinylated Human HLA-A*02:01&B2M&EW (QLQNPSYDK) Complex Protein (Monomer)

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HLA-A*0201 | B2M | AFPHLA-H82E3HumanBiotinylated Human HLA-A*02:01&B2M&AFP (FMNKFIYEI) Complex Protein (Monomer, MALS verified)

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HLA-A*0201 | B2M | TKIHLT-H82E7HumanBiotinylated Human HLA-A*02:01&B2M&TKI (FLLTKILTI) Complex Protein (Monomer, MALS verified)

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HLA-A*0201 | B2M | TRIHLT-H82E9HumanBiotinylated Human HLA-A*02:01&B2M&TRI (FLLTRILTI) Complex Protein (Monomer, MALS verified)

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HLA-A*02:01 & B2M & EWHLE-H52E7HumanHuman HLA-A*02:01&B2M&EW (QLQNPSYDK) Tetramer Protein

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HLA-A*02:01 & B2M & WT-1HLW-H52E6HumanHuman HLA-A*02:01&B2M&WT-1 (RMFPNAPYL) Tetramer Protein (MALS verified)

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HLW-H82E5HumanBiotinylated Human HLA-A*02:01&B2M&WT-1 (RMFPNAPYL) Complex Protein (Monomer, MALS verified)

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HLA-A*02:01 & B2M & GP100HLG-H82E6HumanBiotinylated Human HLA-A*02:01&B2M&GP100 (YLEPGPVTA) Complex Protein (Monomer, MALS verified)

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HLA-A*0201 | B2M & HIV GagHLH-H82E8HumanBiotinylated Human HLA-A*02:01&B2M&HIV Gag (SLYNTVATL) Complex Protein (Monomer, MALS verified)

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HLA-A*0201 | B2M | MAGE-A4HLM-H82E7HumanBiotinylated Human HLA-A*02:01&B2M&MAGE-A4 (GVYDGREHTV) Complex Protein (Monomer, MALS verified)

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HLA-C*07:02:01 & B2M & RYRHLR-H52W2HumanBiotinylated Human HLA-C*07:02:01&B2M&RYR (RYRPGTVAL) Complex Protein (Monomer)

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HLA-A*0201 | B2M & CMV pp65HLC-H82E4HumanBiotinylated Human HLA-A*02:01&B2M&CMV pp65 (NLVPMVATV) Complex Protein (Monomer, MALS verified)

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HLA-A*0201 | B2M | HPV16-E6HLH-HP2H7HumanPE-Labeled Human HLA-A*02:01&B2M&HPV16-E6 (TIHDIILECV) Tetramer Protein

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HLA-A*0201 | B2M | RHAMM-R3HLR-H82E6HumanBiotinylated Human HLA-A*02:01&B2M&RHAMM-R3 (ILSLELMKL) Complex Protein (Monomer, MALS verified)

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HLA-A*02:01 & B2M & mage-a4HLM-H52E3HumanHuman HLA-A*02:01&B2M&mage-a4 (GVYDGREHTV) Tetramer Protein

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HLA-A*02:01 & B2M & NY-ESO-1HL1-H52E7HumanHuman HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Tetramer Protein (MALS verified)

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HL1-H52E8HumanHuman HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein (MALS verified)

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HL1-H82E4HumanBiotinylated Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Complex Protein (Monomer, MALS verified)

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HL1-H82E6HumanBiotinylated Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Complex Protein (Monomer, MALS verified)

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HLA-A*02:01 & B2M & RHAMM-R3HLR-H52E9HumanHuman HLA-A*02:01&B2M&RHAMM-R3 (ILSLELMKL) Tetramer Protein

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HLA-A*02:01 & B2M & Glycipan 3HLG-H52E5HumanHuman HLA-A*02:01&B2M&Glycipan 3 (FVGEFFTDV) Tetramer Protein (MALS verified)

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HLG-H82E4HumanBiotinylated Human HLA-A*02:01&B2M&Glycipan 3 (FVGEFFTDV) Complex Protein (Monomer, MALS verified)

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HLA-A*02:01 & B2M & Peptide (KVLEHVVRV)HLK-H52E5HumanHuman HLA-A*02:01&B2M&Peptide (KVLEHVVRV) Tetramer Protein (MALS verified)

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アッセイデータ

FACSで確認された高い結合親和性

The activity of PE-Labeled Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Tetramer Protein was higher than that of other competitor.

2e5 of NY-ESO-1 TCR-HEK293 cells (pool) were stained with PE-Labeled  Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) tetramer Protein（Fig B）and negative control protein respectively (Fig. A), and competitor-M represented competitor protein (Fig. C). PE signal was used to evaluate the binding activity

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SPRで確認された高い結合親和性

Biotinylated Human HLA-A*02:01 NY-ESO-1

Anti-NY-ESO-1 antibody captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Biotinylated Human HLA-A0201 NY-ESO-1 (SLLMWITQC) Complex Protein (Cat. No. HL1-H82E6) with an affinity constant of 16.9 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Human HLA-A*02:01 NY-ESO-1

Anti-NY-ESO-1 antibody captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human HLA-A0201 NY-ESO-1 (SLLMWITQC) Tetramer Protein (Cat. No. HL1-H52E8) with an affinity constant of 1.35 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Biotinylated Human HLA-C*07:02:01 & B2M & RYR

Biotinylated Human HLA-C*07:02:01 & B2M & RYR ,His,Avitag™&Tag Free (Cat. No. HLR-H52W2) immobilized on SA Chip can bind Human KIR2DL3, Fc Tag (Cat. No. KI3-H5258) with an affinity constant of 2.40 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Biotinylated Human HLA-C*07:02:01 & B2M & RYR

Biotinylated Human HLA-C*07:02:01 & B2M & RYR ,His,Avitag™&Tag Free (Cat. No. HLR-H52W2) immobilized on SA Chip can bind Human KIR2DL2, Fc Tag (Cat. No. KI2-H5255) with an affinity constant of 1.01 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

ELISAで確認された高い結合親和性

Biotinylated Human HLA-A*02:01 NY-ESO-1(SLLMWITQC)

Immobilized Biotinylated Human HLA-A*02:01 NY-ESO-1 (SLLMWITQC) Complex Protein (Cat. No. HL1-H82E6) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-NY-ESO-1 Antibody, Human IgG1 with a linear range of 0.1-8 ng/mL (QC tested).

Biotinylated Human HLA-A*02:01 NY-ESO-1 (SLLMWITQV)

Immobilized Biotinylated Human HLA-A*02:01 NY-ESO-1 (SLLMWITQV) Complex Protein (Cat. No. HL1-H82E4) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-NY-ESO-1 Antibody, Human IgG1 with a linear range of 0.2-16 ng/mL (QC tested).

関連製品


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リファレンス

  • 1.Thomas C, Tampé R. MHC I assembly and peptide editing - chaperones, clients, and molecular plasticity in immunity. Curr Opin Immunol. 2021 Jun;70:48-56. doi: 10.1016/j.coi.2021.02.004. Epub 2021 Mar 6. PMID: 33689959.

  • 2.Becar M, Kasi A. Physiology, MHC Class I. 2021 Sep 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 32310482.

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