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PE-Labeled Monoclonal Anti-Human TIGIT Antibody, Rabbit IgG (M1G03) (0.03% Proclin)

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製品番号/仕様
価格
数量
FABr054-01-200tests (50tests X 4)
$400.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0
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製品詳細

  • Source

    Monoclonal Anti-Human TIGIT Antibody, Rabbit IgG (M1G03) is a rabbit monoclonal antibody recombinantly expressed from human 293 cells (HEK293), which provides higher batch consistency and long term security of supply. It shows superior performance in flow cytometry assays with higher affinity and better specificity.

  • Antibody Type

    Recombinant Monoclonal

  • Clone

    M1G03

  • Isotype

    Rabbit IgG, Kappa

  • Host Species

    Rabbit

  • Reactivity

    Human

  • Immunogen

    Purified Human TIGIT Protein

  • Conjugate

    PE

    Excitation Wavelength: 488 nm / 561 nm

    Emission Wavelength: 575 nm

  • Specificity

    This product is a specific antibody specifically reacts with TIGIT protein.

  • Application

    Flow Cytometry (Detection the expression of TIGIT on Human cells).

  • Recommended Dilution

    1:20

  • Form

    Liquid

  • Formulation

    Supplied as 0.2 μm-filtered solution in PBS (pH 7.4) containing 0.03% ProClin 300 and 0.2% BSA, with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Shipping

    Liquid product is shipped at blue ice.

  • Storage

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. Store at 2-8 °C for 12 months.

  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • Bioactivity-FACS

    TIGIT FACS

    Flow cytometric analysis of Human TIGIT (Luc) Jurkat Reporter cells staining with PE-Labeled Monoclonal Anti-Human TIGIT Antibody, Rabbit IgG(M1G03) (Cat. No. FABr054-01) at 1:20 dilution (5 μL of the antibody stock solution corresponds to labeling of 1e6 cells in a final volume of 100 µL), compared with isotype control antibody. PE signal was used to evaluate the binding activity (QC tested).

    Protocol

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バックグランド

T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

最新の進展

 
医薬品開発の進捗
  • 英語名：

    T cell immunoglobulin and ITIM domains

  • カテゴリ：

  • 市販の医薬品数：

    0 詳細

  • 治験医薬品数：

    41 詳細

  • 最新の開発ステージ：

    Phase 3 Clinical

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