Alexa Fluor™ 488-Labeled Human Alpha-synuclein Protein, Tag Free

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製品番号/仕様
価格
数量
ALN-HA113-200ug
$840.00
ALN-HA113-1mg
$3150.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    NACP, PARK1, PARK4, PD1

  • Source

    Alexa Fluor 488-Labeled Human Alpha-synuclein Protein, Tag Free (ALN-HA113) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1). It is the Alexa Fluor™ 488 labeled form of Human Alpha-Synuclein, Tag Free (Cat. No. ALN-H5214).

    Predicted N-terminus: Met 1

    Request for sequence
  • Molecular Characterization

    Alpha-synuclein Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries no "tag".

    The protein has a calculated MW of 14.5 kDa. The protein migrates as 15-17 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

  • Conjugate

    AF488

    Excitation Wavelength: 488 nm

    Emission Wavelength: 517 nm

  • Labeling

    The primary amines in the side chains of lysine residues and the N-terminus of the protein are conjugated with AF488 using standard chemical labeling method. The residual AF488 is removed by molecular sieve treatment during purification process.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Supplied as 0.2 μm filtered solution in PBS, pH7.4, 0.03% Proclin300 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    Alpha-synuclein SDS-PAGE

    Alexa Fluor 488-Labeled Human Alpha-synuclein Protein, Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • Bioactivity-ELISA

     Alpha-synuclein ELISA

    Immobilized Alexa Fluor 488-Labeled Human Alpha-synuclein Protein, Tag Free (Cat. No. ALN-HA113) at 1 μg/mL (100 μL/well) can bind Synuclein alpha/beta Antibody with a linear range of 0.1-2 ng/mL (QC tested).

    Protocol

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バックグランド

Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Synuclein alpha

  • カテゴリ:

  • 市販の医薬品数:

    0 詳細

  • 治験医薬品数:

    25 詳細

  • 最新の開発ステージ:

    Phase 3 Clinical

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