Human BAFFR / TNFRSF13C Protein, His Tag, low endotoxin (MALS verified)

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製品番号/仕様
価格
数量
BAR-H52H3-100ug
$460.00
BAR-H52H3-1mg
$2745.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    BAFFR, TNFRSF13C, BROMIX, CD268, CVID4, prolixin, BAFF-R

  • Source

    Human BAFFR Protein, His Tag (BAR-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ser 7 - Ala 71 (Accession # Q96RJ3-1).

    Request for sequence
  • Molecular Characterization

    BAFFR Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 8.6 kDa. The protein migrates as 17-22 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    BAFFR SDS-PAGE

    Human BAFFR Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    BAFFR SEC-MALS

    The purity of Human BAFFR Protein, His Tag (Cat. No. BAR-H52H3) is more than 85% and the molecular weight of this protein is around 13-19 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     BAFFR ELISA

    Immobilized Human BAFF, Fc Tag, active trimer (Cat. No. BAF-H5261) at 1 μg/mL (100 μL/well) can bind Human BAFFR Protein, His Tag (Cat. No. BAR-H52H3) with a linear range of 2-13 ng/mL (QC tested).

    Protocol

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バックグランド

BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    B-cell activating factor receptor

  • カテゴリ:

  • 市販の医薬品数:

    0 詳細

  • 治験医薬品数:

    14 詳細

  • 最新の開発ステージ:

    NDA/BLA

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