Cynomolgus / Rhesus macaque BCMA / TNFRSF17 Protein, His Tag (HPLC verified)

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製品番号/仕様
価格
数量
BCA-C52H7-100ug
$415.00
BCA-C52H7-1mg (500ug X 2)
$2830.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    TNFRSF17, CD269, BCM, BCMA

  • Source

    Cynomolgus / Rhesus macaque BCMA, His Tag (BCA-C52H7) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 53 (Accession # A0A2K5UD97-1). In the region Met 1 - Ala 53, the amino acid sequences of Cynomolgus and Rhesus macaque BCMA are identical.

    Predicted N-terminus: Met 1

    Request for sequence
  • Molecular Characterization

    BCMA Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 7.9 kDa. The protein migrates as 13-14 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    BCMA SDS-PAGE

    Cynomolgus / Rhesus macaque BCMA, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-HPLC

    BCMA SEC-HPLC

    The purity of Cynomolgus / Rhesus macaque BCMA, His Tag (Cat. No. BCA-C52H7) was greater than 85% as determined by SEC-HPLC.

  • Bioactivity-ELISA

     BCMA ELISA

    Immobilized Cynomolgus / Rhesus macaque BCMA, His Tag (Cat. No. BCA-C52H7) at 2 μg/mL (100 μL/well) can bind Human BAFF, Fc Tag, active trimer (Cat. No. BAF-H5261) with a linear range of 0.2-3 ng/mL (QC tested).

    Protocol

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バックグランド

Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    B-cell maturation protein

  • カテゴリ:

  • 市販の医薬品数:

    8 詳細

  • 治験医薬品数:

    145 詳細

  • 最新の開発ステージ:

    Approved

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