Human Cadherin-6 / KCAD / CDH6 Protein, His Tag, low endotoxin (HPLC verified)

ユーザーレビュー
製品番号/仕様
価格
数量
CA6-H5229-100ug
$310.00
CA6-H5229-1mg (500ug X 2)
$2140.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    CDH6, CAD6, KCAD, K-cadherin, Cadherin-6

  • Source

    Human Cadherin-6, His Tag (CA6-H5229) is expressed from human 293 cells (HEK293). It contains AA Thr 19 - Ala 615 (Accession # AAH00019).

    Predicted N-terminus: Thr 19 & Ser 54

    Request for sequence
  • Molecular Characterization

    Cadherin-6 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus. The Human Cadherin-6 will be further processed into mature form (Ser 54-Ala 615). The protein has a calculated MW of 63.4 kDa. The protein migrates as 86-96 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >85% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

お客様はこちらも閲覧

データ表示

  • SDS-PAGE

    Cadherin-6 SDS-PAGE

    Human Cadherin-6, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 85% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-HPLC

    Cadherin-6 SEC-HPLC

    The purity of Human Cadherin-6, His Tag (Cat. No. CA6-H5229) was greater than 85% as determined by SEC-HPLC.

  • Bioactivity-ELISA

     Cadherin-6 ELISA

    Immobilized Human Cadherin-6, His Tag (Cat. No. CA6-H5229) at 1 μg/mL (100 μL/well) can bind Human Cadherin-6 Antibody, Mouse IgG1 with a linear range of 0.1-1 ng/mL (QC tested).

    Protocol
  •  Cadherin-6 ELISA

    Immobilized Human Cadherin-6, His Tag (Cat. No. CA6-H5229) at 1 μg/mL (100 μL/well) can bind Raludotatug with a linear range of 0.02-1 ng/mL (Routinely tested).

    Protocol

ユーザーレビュー
コメントを投稿

  • 1***62022-08-09
    いいね
    Validated by SPR, measured monovalent affinity, anti-human FC chip, load diluted antibody, added diluted CDH6, His tag, with the affinity constant of 4.72 nM.

バックグランド

Cadherin-6 (CDH6) is also known as Kidney cadherin (K-cadherin or KCAD), is a a type II classical cadherin from the cadherin superfamily. Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH6 / KCAD contains five cadherin domains. CDH6 is highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression and also expressed in certain liver and kidney carcinomas.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Cadherin-6

  • カテゴリ:

  • 市販の医薬品数:

    0 詳細

  • 治験医薬品数:

    5 詳細

  • 最新の開発ステージ:

    Phase 3 Clinical

お問い合わせ
医薬品候補ライセンス
他の関連情報
  • 製品情報
  • 製品詳細
  • お客様はこちらも閲覧
  • データ表示
  • ユーザーレビュー
  • 背景
お問い合わせ

お問い合わせ
グローバル:+1 800-810-0816(Toll Free)

メールアドレス
order.jp@acrobiosystems.com

アクロバイオシステムズ株式会社
〒101-0051
東京都千代田区神田神保町1-32-8