Human CCL2 / MCP-1 Protein, Fc Tag (MALS verified)

ユーザーレビュー
製品番号/仕様
価格
数量
CC2-H5255-20ug
$185.00
CC2-H5255-50ug
$370.00
CC2-H5255-1mg
$3400.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    CCL2, C-C motif chemokine 2, MCP-1, MCAF

  • Source

    Human CCL2, Fc Tag (CC2-H5255) is expressed from human 293 cells (HEK293). It contains AA Gln 24 - Thr 99 (Accession # P13500-1).

    Predicted N-terminus: Gln 24

    Request for sequence
  • Molecular Characterization

    CCL2 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 35.1 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

お客様はこちらも閲覧

データ表示

  • SDS-PAGE

    CCL2 SDS-PAGE

    Human CCL2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • SEC-MALS

    CCL2 SEC-MALS

    The purity of Human CCL2, Fc Tag (Cat. No. CC2-H5255) is more than 95% and the molecular weight of this protein is around 68-88 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     CCL2 ELISA

    Immobilized Human CCL2, Fc Tag (Cat. No. CC2-H5255) at 5 μg/mL (100 μL/well) can bind Human CCR2 Full Length Protein, Flag,His Tag (Cat. No. CC2-H52D4) with a linear range of 0.005-0.313 μg/mL (QC tested).

    Protocol
  •  CCL2 ELISA

    Immobilized Human CCL2, Fc Tag (Cat. No. CC2-H5255) at 5 μg/mL (100 μL/well) can bind Anti-MCP-1 / CCL2 Antibody, Mouse Fc (1B7) with a linear range of 0.2-5 ng/mL (Routinely tested).

    Protocol

ユーザーレビュー
コメントを投稿

バックグランド

Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. CCL2, a member of the CC subfamily, is characterized by two adjacent cysteine residues. CCL2 displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    C-C motif chemokine 2

  • カテゴリ:

  • 市販の医薬品数:

    1 詳細

  • 治験医薬品数:

    3 詳細

  • 最新の開発ステージ:

    Approved

お問い合わせ
医薬品候補ライセンス
他の関連情報
  • 製品情報
  • 製品詳細
  • お客様はこちらも閲覧
  • データ表示
  • ユーザーレビュー
  • 背景
お問い合わせ

お問い合わせ
グローバル:+1 800-810-0816(Toll Free)

メールアドレス
order.jp@acrobiosystems.com

アクロバイオシステムズ株式会社
〒101-0051
東京都千代田区神田神保町1-32-8