Cynomolgus CD3 epsilon (22-48) Protein, Fc Tag, low endotoxin (MALS verified)

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製品番号/仕様
価格
数量
CDE-C5253-100ug
$390.00
CDE-C5253-1mg
$2691.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    FLJ18683, T3E, TCRE, CD3E, CD3-epsilon

  • Source

    Cynomolgus CD3 epsilon (22-48) Protein, Fc Tag (CDE-C5253) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Thr 48 (Accession # Q95LI5 ).

    Request for sequence
  • Molecular Characterization

    CD3 epsilon Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 29.3 kDa. The protein migrates as 33-43 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    CD3 epsilon SDS-PAGE

    Cynomolgus CD3 epsilon (22-48) Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    CD3 epsilon SEC-MALS

    The purity of Cynomolgus CD3 epsilon (22-48) Protein, Fc Tag (Cat. No. CDE-C5253) is more than 90% and the molecular weight of this protein is around 60-75 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     CD3 epsilon ELISA

    Immobilized Cynomolgus CD3 epsilon (22-48) Protein, Fc Tag (Cat. No. CDE-C5253) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human CD3 Antibody, Mouse IgG1 (SP34-2) (Cat. No. CDE-M531) with a linear range of 0.1-2 ng/mL (QC tested).

    Protocol

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バックグランド

The Gln22-Thr48 region of Cynomolgus CD3E is a core part of its extracellular immunoglobulin-like (Ig-like) domain.
Its primary function is to act as a crucial structural scaffold, mediating proper interactions with other CD3 subunits (specifically CD3G and CD3D).
It is also considered as SP34 binding site.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    T-cell surface glycoprotein CD3 epsilon chain

  • カテゴリ:

  • 市販の医薬品数:

    4 詳細

  • 治験医薬品数:

    7 詳細

  • 最新の開発ステージ:

    Approved

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