Human CD74 / DHLAG Protein, Llama IgG2b Fc Tag, low endotoxin

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製品番号/仕様
価格
数量
CD4-H5258-100ug
$390.00
CD4-H5258-1mg (200ug X 5)
$2575.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    CD74, DHLAG, HLADG, II, Ia-GAMMA, p33, CLIP, INVG34

  • Source

    Human CD74 Protein, Llama IgG2b Fc Tag (CD4-H5258) is expressed from human 293 cells (HEK293). It contains AA Gln 73 - Met 232 (Accession # P04233-2).

    Predicted N-terminus: Met

    Request for sequence
  • Molecular Characterization

    CD74 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a llama IgG2b Fc tag at the N-terminus.

    The protein has a calculated MW of 49.4 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    CD74 SDS-PAGE

    Human CD74 Protein, Llama IgG2b Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

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バックグランド

Cluster of Differentiation 74 (CD74) is also known as HLA class II histocompatibility antigen gamma chain (HLADG), DHLAG, Ia-GAMMA, invariant chain (Abbreviated Ii). CD74 / HLADG is a polypeptide involved in the formation and transport of MHC class II protein. The cell surface form of the invariant chain is known as CD74. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation. CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha / beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal / lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 / DHLAG also serves as cell surface receptor for the cytokine MIF.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    HLA-DR antigens-associated invariant chain

  • カテゴリ:

  • 市販の医薬品数:

    0 詳細

  • 治験医薬品数:

    5 詳細

  • 最新の開発ステージ:

    Phase 1 Clinical

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