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製品詳細
Synonyms
BGR, CANDF4, CD369, CLECSF12, DECTIN1, SCARE2
Source
Cynomolgus CLEC7A Protein, His Tag (CL7-C5243) is expressed from human 293 cells (HEK293). It contains AA Thr 100 - Met 281 (Accession # A0A2K5UXY6).
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 22.5 kDa. The protein migrates as 30-37 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 0.01 EU per μg by the LAL method / rFC method.
Purity
>95% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System
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データ表示
SDS-PAGE
Cynomolgus CLEC7A Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).
SEC-MALS
The purity of Cynomolgus CLEC7A Protein, His Tag (Cat. No. CL7-C5243) is more than 95% and the molecular weight of this protein is around 25-40 kDa verified by SEC-MALS.
Report
Bioactivity-ELISA
Immobilized Cynomolgus CLEC7A Protein, His Tag (Cat. No. CL7-C5243) at 1 μg/mL (100 μL/well) can bind CD369 (Clec7a, Dectin-1) Monoclonal Antibody (15E2), Mouse IgG2a with a linear range of 2-125 ng/mL (QC tested).
Protocol
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バックグランド
Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity).
Enhances cytokine production in macrophages and dendritic cells (By similarity).
Mediates production of reactive oxygen species in the cell (By similarity).
Mediates phagocytosis of C.albicans conidia (PubMed:17230442).
Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity).
最新の進展
医薬品開発の進捗- 英語名：
C-type lectin domain family 7 member A
- カテゴリ：
- 市販の医薬品数：
0 詳細
- 治験医薬品数：
1 詳細
- 最新の開発ステージ：
Clinical
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