Human CXCR4 / CD184 Protein, Fc Tag

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製品番号/仕様
価格
数量
CX4-H5269-50ug
$310.00
CX4-H5269-1mg (500ug X 2)
$2720.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    CXCR4, CD184, Fusin, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM

  • Source

    Human CXCR4, Fc Tag (CX4-H5269) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ser 46 (Accession # AAH20968.1).

    Request for sequence
  • Molecular Characterization

    CXCR4 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the N-terminus.

    The protein has a calculated MW of 32.3 kDa. The protein migrates as 35-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    CXCR4 SDS-PAGE

    Human CXCR4, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

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バックグランド

A chemokine receptor with pleiotropic roles in hematopoietic stem cell homing to bone marrow and cancer metastasis. The CXCL12/CXCR4 axis is a key retention signal for stem cells and malignant plasma cells. Antagonists (plerixafor) are standard-of-care for stem cell mobilization and are being developed for solid tumor therapy.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    C-X-C motif chemokine receptor 4

  • カテゴリ:

  • 市販の医薬品数:

    3 詳細

  • 治験医薬品数:

    30 詳細

  • 最新の開発ステージ:

    Approved

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