Mouse DLL3 Protein, His Tag, low endotoxin (HPLC verified)

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製品番号/仕様
価格
数量
DL3-M52H9-100ug
$375.00
DL3-M52H9-1mg (500ug X 2)
$2895.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    Delta3, delta-like 3 (Drosophila), delta-like protein 3, DLL3, Pudgy, SCDO1, SCDO1delta3

  • Source

    Mouse DLL3, His Tag (DL3-M52H9) is expressed from human 293 cells (HEK293). It contains AA Ala 25 - Arg 488 (Accession # O88516-1).

    Predicted N-terminus: Asp

  • Molecular Characterization

    This protein carries a polyhistidine tag at the C-terminus and a fusion design at the N-terminus. The protein has a calculated MW of 118 kDa. The protein migrates as 100-115 kDa under reducing (R) condition (SDS-PAGE).

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    DLL3 SDS-PAGE

    Mouse DLL3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-HPLC

    DLL3 SEC-HPLC

    The purity of Mouse DLL3, His Tag (Cat. No. DL3-M52H9) was greater than 85% as determined by SEC-HPLC.

  • Bioactivity-ELISA

     DLL3 ELISA

    Immobilized Mouse DLL3, His Tag (Cat. No. DL3-M52H9) at 1 μg/mL (100 μL/well) can bind Anti-DLL3 Antibody (specific Binding EGFs of DLL3), Human IgG1 with a linear range of 0.1-2 ng/mL (QC tested).

    Protocol
  •  DLL3 ELISA

    Immobilized Mouse DLL3, His Tag (Cat. No. DL3-M52H9) at 1 μg/mL (100 μL/well) can bind Anti-DLL3 Antibody (specific Binding DSL of DLL3), Human IgG1 with a linear range of 0.1-2 ng/mL (Routinely tested).

    Protocol
  • Bioactivity-SPR

     DLL3 SPR

    Bispecific T-cell Engager captured on Protein A Chip can bind Mouse DLL3, His Tag (Cat. No. DL3-M52H9) with an affinity constant of 1.13 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

    Protocol

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バックグランド

Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands.May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 protein is expressed on the surface of tumor cells but not in normal adult tissues.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Delta-like protein 3

  • カテゴリ:

  • 市販の医薬品数:

    1 詳細

  • 治験医薬品数:

    28 詳細

  • 最新の開発ステージ:

    Approved

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