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Product Details
Synonyms
GDF-8, Myostatin, GDF8, MSTN, Growth, differentiation factor 8
Source
Human latent GDF-8 Protein, His Tag (GD8-H5343) is expressed from CHO cells. It contains AA Asn 24 - Ser 375 (Accession # O14793-1).
Predicted N-terminus: Asn 24
Request for sequenceMolecular Characterization
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 42.0 kDa. The protein migrates as 10-11 kDa and 38-40 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
The protein is designed as a dimer.
Endotoxin
Less than 0.01 EU per μg by the LAL method / rFC method.
Purity
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Performance Data
SDS-PAGE
Human latent GDF-8 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).
SEC-MALS
The purity of Human latent GDF-8 Protein, His Tag (Cat. No. GD8-H5343) is more than 90% and the molecular weight of this protein is around 78-108 kDa verified by SEC-MALS.
Report
Bioactivity-ELISA
Immobilized Human latent GDF-8 Protein, His Tag (Cat. No. GD8-H5343) at 5 μg/mL (100 μL/well) can bind Human Activin RIIB Protein, Fc Tag (Cat. No. ACB-H5254) with a linear range of 0.06-8 ng/mL (QC tested).
Protocol
Immobilized Human latent GDF-8 Protein, His Tag (Cat. No. GD8-H5343) at 5 μg/mL (100 μL/well) can bind Biotinylated Human Activin RIIB Protein, Fc,Avitag (Cat. No. ACB-H82F3) with a linear range of 0.1-16 ng/mL (Routinely tested).
Protocol
Immobilized Human latent GDF-8 Protein, His Tag (Cat. No. GD8-H5343) at 5 μg/mL (100 μL/well) can bind Human Follistatin Protein, Fc Tag (Cat. No. FON-H5256) with a linear range of 0.2-31 ng/mL (Routinely tested).
Protocol
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Background
Recent Advances
Drug Development Progress- English Name：
Growth/differentiation factor 8
- Category：
- Approved Drugs：
0 Details
- Drugs in Clinical Trials：
8 Details
- Highest Development Stage：
NDA/BLA
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