Cynomolgus Glypican 3 / GPC3 Protein, Fc Tag, low endotoxin

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製品番号/仕様
価格
数量
GP3-C5256-100ug
$300.00
GP3-C5256-1mg (500ug X 2)
$2040.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    GPC3, OCI5, Glypican-3, GTR2-2, MXR7, DGSX, SDYS , SGB, SGBS, SGBS1

  • Source

    Cynomolgus Glypican 3, Fc Tag (GP3-C5256) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Arg 358 & Ser 359 - His 559 (Accession # XP_005594665.1).

    Predicted N-terminus: Gln 25 & Ser 359

    Request for sequence
  • Molecular Characterization

    Glypican 3 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 38.1 kDa & 49.4 kDa. The protein migrates as 40-43 kDa, 60-65 kDa and 95-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    Glypican 3 SDS-PAGE

    Cynomolgus Glypican 3, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • Bioactivity-ELISA

     Glypican 3 ELISA

    Immobilized Human FGF basic, premium grade (Cat. No. BFF-H4117) at 2 μg/mL (100 μL/well) can bind Cynomolgus Glypican 3, Fc Tag (Cat. No. GP3-C5256) with a linear range of 1-31 ng/mL (QC tested).

    Protocol
  •  Glypican 3 ELISA

    Immobilized Cynomolgus Glypican 3, Fc Tag (Cat. No. GP3-C5256) at 0.5 μg/mL (100 μL/well) can bind Monoclonal Anti-Human GPC3 Antibody, Human IgG1 with a linear range of 0.2-3 ng/mL (Routinely tested).

    Protocol

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バックグランド

Glypican-3 (GPC3) is also known as Intestinal protein OCI-5, GTR2-2, MXR7, which belongs to the glypican family. Glypican 3 / GPC-3 is highly expressed in lung, liver and kidney. Glypican-3 inhibits the dipeptidyl peptidase activity of DPP4. Glypican-3 may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and also may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Glypican-3

  • カテゴリ:

  • 市販の医薬品数:

    0 詳細

  • 治験医薬品数:

    57 詳細

  • 最新の開発ステージ:

    Phase 2 Clinical

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