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Product Details
Synonyms
IFNAR1, IFNAR, CRF2-1, IFN-R-1, IFNAR-1
Source
Human IFN-alpha / beta R1 Protein, His Tag (IF1-H5225) is expressed from human 293 cells (HEK293). It contains AA Lys 28 - Lys 436 (Accession # P17181-1).
Predicted N-terminus: Lys 28
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 49.0 kDa. The protein migrates as 65-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 0.01 EU per μg by the LAL method / rFC method.
Purity
>95% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Shipping and Storage
This product is shipped at ambient temperature.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Performance Data
SDS-PAGE
Human IFN-alpha / beta R1 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.
SEC-MALS
The purity of Human IFN-alpha / beta R1 Protein, His Tag (Cat. No. IF1-H5225) is more than 95% and the molecular weight of this protein is around 60-81 kDa verified by SEC-MALS.
Report
Bioactivity-SPR
Human IFN-alpha 1, Fc Tag (Cat. No. IFA-H5258) captured on Protein A Chip can bind Human IFN-alpha / beta R1 Protein, His Tag (Cat. No. IF1-H5225) with an affinity constant of 5.14 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Protocol
Bioactivity-BLI
Loaded Human IFNAR1, His Tag (Cat. No. IF1-H5225) on NTA Biosensor, can bind Human IFN-alpha 2b Protein, Fc Tag (Cat. No. IFB-H5253) with an affinity constant of 0.689 μM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).
Protocol
Loaded Human IFN-alpha / beta R1, His Tag (Cat. No. IF1-H5225) on NTA Biosensor, can bind Human IFN-alpha 1, Fc Tag (Cat. No. IFA-H5258) with an affinity constant of 11.3 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
Protocol
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Background
Recent Advances
Drug Development Progress- English Name：
Interferon-alpha/beta receptor alpha chain
- Category：
- Approved Drugs：
5 Details
- Drugs in Clinical Trials：
0 Details
- Highest Development Stage：
Approved
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