Human IFN-alpha / beta R1 Protein, Fc Tag

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製品番号/仕様
価格
数量
IF1-H5253-100ug
$330.00
IF1-H5253-1mg (500ug X 2)
$2245.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    IFNAR1, IFNAR, CRF2-1, IFN-R-1, IFNAR-1

  • Source

    Human IFNAR1, Fc Tag (IF1-H5253) is expressed from human 293 cells (HEK293). It contains AA Lys 28 - Lys 436 (Accession # NP_000620).

    Predicted N-terminus: Lys 28

    Request for sequence
  • Molecular Characterization

    IFN-alpha/beta R1 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 73.8 kDa. The protein migrates as 100-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >85% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    IFN-alpha/beta R1 SDS-PAGE

    Human IFNAR1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 85%.

  • Bioactivity-SPR

     IFN-alpha/beta R1 SPR

    Human IFNAR1, Fc Tag (Cat. No. IF1-H5253) captured on Protein A Chip can bind Human IFN-alpha 1, His Tag (Cat. No. IFA-H52H9) with an affinity constant of 0.382 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

    Protocol
  • Bioactivity-BLI

     IFN-alpha/beta R1 BLI

    Loaded Human IFN-alpha 1, His Tag (Cat. No. IFA-H52H9) on HIS1K Biosensor, can bind Human IFNAR1, Fc Tag (Cat. No. IF1-H5253) with an affinity constant of 0.191 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

    Protocol

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バックグランド

Interferon alpha/beta receptor 1 ( IFNAR1) is also known as Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1 (CRF2-1), Type I interferon receptor 1, IFNAR, which belongs to the type II cytokine receptor family. IFNAR1 /IFNAR contains four fibronectin type-III domains. IFNAR1 associates with IFNAR2 to form the type I interferon receptor. IFNAR1 is receptor for interferons alpha and beta. IFNAR1 can transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Interferon-alpha/beta receptor alpha chain

  • カテゴリ:

  • 市販の医薬品数:

    5 詳細

  • 治験医薬品数:

    0 詳細

  • 最新の開発ステージ:

    Approved

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