Human IGF-II R (43-1365) Protein, His Tag (MALS verified)

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製品番号/仕様
価格
数量
IGR-H52H4-100ug
$360.00
IGR-H52H4-1mg (500ug X 2)
$2380.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    Cation-independent mannose-6-phosphate receptor, CI Man-6-P receptor, CI-MPR, M6PR, 300 kDa mannose 6-phosphate receptor (MPR 300), Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor (IGF-II receptor), M6P/IGF2 receptor (M6P/IGF2R), CD222

  • Source

    Human IGF-II R (43-1365) Protein, His Tag (IGR-H52H4) is expressed from human 293 cells (HEK293). It contains AA Ala 43 - Asp 1365 (Accession # P11717).

    Predicted N-terminus: Ala 43

    Request for sequence
  • Molecular Characterization

    IGF-II R Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 148.2 kDa. The protein migrates as 150-180 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    IGF-II R SDS-PAGE

    Human IGF-II R (43-1365) Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    IGF-II R SEC-MALS

    The purity of Human IGF-II R (43-1365) Protein, His Tag (Cat. No. IGR-H52H4) is more than 90% and the molecular weight of this protein is around 150-180 kDa verified by SEC-MALS.

    Report

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バックグランド

IGF2R, also known as the cation-independent mannose-6-phosphate receptor, is found ubiquitously in human tissues with a truncated soluble form of the receptor present in the circulation. Full-length, 300-kDa, IGF2R comprises a large N-terminal extracellular region of 15 homologous domains, a single membrane-spanning region and a small cytoplasmic tail. In addition to IGF-II binding, major IGF2R functions include sorting newly synthesized lysosomal enzymes and endocytosis of extracellular lysosomal enzymes. To perform these disparate functions, the extracellular region contains binding sites for IGF-II and phosphomannosyl residues

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Insulin-like growth factor II receptor

  • カテゴリ:

  • 市販の医薬品数:

    1 詳細

  • 治験医薬品数:

    0 詳細

  • 最新の開発ステージ:

    Approved

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