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Product Details
Synonyms
IL2RB, RP5-1170K4.6, CD122, P70-75
Source
Cynomolgus IL-2 R beta Protein, Fc Tag (ILA-C5253) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Thr 240 (Accession # Q38J85-1).
Predicted N-terminus: Ala 27
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 51.2 kDa. The protein migrates as 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>90% as determined by SDS-PAGE.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
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Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Performance Data
SDS-PAGE
Cynomolgus IL-2 R beta Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).
Bioactivity-ELISA
Immobilized Cynomolgus / Rhesus macaque IL-15, His Tag (Cat. No. IL5-C52H4) at 5 μg/mL (100 μL/well) can bind Cynomolgus IL-2 R beta Protein, Fc Tag (Cat. No. ILA-C5253) with a linear range of 0.2-10 ng/mL (QC tested).
Protocol
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Background
CD122 is also known as IL2R beta, is a member of the type I cytokine receptor family. CD122 is the receptor for interleukin-2 and is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.
Recent Advances
Drug Development Progress- English Name：
Interleukin-2 receptor beta chain
- Category：
- Approved Drugs：
0 Details
- Drugs in Clinical Trials：
15 Details
- Highest Development Stage：
Phase 3 Clinical
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