Cynomolgus IL-4 Protein, Fc Tag (MALS verified)

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製品番号/仕様
価格
数量
IL4-C5259-100ug
$395.00
IL4-C5259-1mg
$2615.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    IL4, BCGF1, BSF1

  • Source

    Cynomolgus IL-4, Fc Tag (IL4-C5259) is expressed from human 293 cells (HEK293). It contains AA His 25 - Ser 153 (Accession # P79339-1).

    Predicted N-terminus: His 25

    Request for sequence
  • Molecular Characterization

    IL-4 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 41.4 kDa. The protein migrates as 46-50 kDa and 53 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    IL-4 SDS-PAGE

    Cynomolgus IL-4, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • SEC-MALS

    IL-4 SEC-MALS

    The purity of Cynomolgus IL-4, Fc Tag (Cat. No. IL4-C5259) is more than 95% and the molecular weight of this protein is around 85-115 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     IL-4 ELISA

    Immobilized Cynomolgus / Rhesus macaque IL-4 R alpha, His Tag (Cat. No. ILR-C52H8) at 5 μg/mL (100 μL/well) can bind Cynomolgus IL-4, Fc Tag (Cat. No. IL4-C5259) with a linear range of 0.1-4 ng/mL (QC tested).

    Protocol

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バックグランド

Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Interleukin-4

  • カテゴリ:

  • 市販の医薬品数:

    2 詳細

  • 治験医薬品数:

    14 詳細

  • 最新の開発ステージ:

    Approved

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