Human MAdCAM-1 Protein, Fc Tag, low endotoxin (MALS verified)

ユーザーレビュー
製品番号/仕様
価格
数量
MAM-H5253-100ug
$355.00
MAM-H5253-1mg
$2245.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    MAdCAM-1, MAdCAM1, Mucosal vascular addressin cell adhesion molecule 1 transcript variant 1

  • Source

    Human MAdCAM-1, Fc Tag (MAM-H5253) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Gln 333 (Accession # Q4PKD0-1).

    Predicted N-terminus: Gln 19

    Request for sequence
  • Molecular Characterization

    MAdCAM-1 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 59.6 kDa. The protein migrates as 70-100 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

お客様はこちらも閲覧

データ表示

  • SDS-PAGE

    MAdCAM-1 SDS-PAGE

    Human MAdCAM-1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    MAdCAM-1 SEC-MALS

    The purity of Human MAdCAM-1, Fc Tag (Cat. No. MAM-H5253) is more than 95% and the molecular weight of this protein is around 145-175 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     MAdCAM-1 ELISA

    Immobilized Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT7-H52W4) at 2 μg/mL (100 μL/well) can bind Human MAdCAM-1, Fc Tag (Cat. No. MAM-H5253) with a linear range of 0.05-1 ng/mL (QC tested).

    Protocol
  • Bioactivity-SPR

     MAdCAM-1 SPR

    Human MAdCAM-1, Fc Tag (Cat. No. MAM-H5253) captured on Protein A Chip can bind Cynomolgus ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT7-C52W4) with an affinity constant of 5.77 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

    Protocol

ユーザーレビュー
コメントを投稿

バックグランド

The mucosal addressin cell adhesion molecule-1 (MAdCAM-1) takes a key role in the endothelial adhesion and migration of lymphocytes to sites of inflammation in inflammatory disease. In vitro and in vivo data indicate that blockade of the adhesion molecule mucosal address in cell adhesion molecule (MAdCAM) pathway decreases leukocyte homing to the gut by inhibiting the interaction between MAdCAM and its ligand the α4β7 integrin expressed on lymphocytes.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Mucosal addressin cell adhesion molecule-1

  • カテゴリ:

  • 市販の医薬品数:

    1 詳細

  • 治験医薬品数:

    4 詳細

  • 最新の開発ステージ:

    Approved

お問い合わせ
医薬品候補ライセンス
他の関連情報
  • 製品情報
  • 製品詳細
  • お客様はこちらも閲覧
  • データ表示
  • ユーザーレビュー
  • 背景
お問い合わせ

お問い合わせ
グローバル:+1 800-810-0816(Toll Free)

メールアドレス
order.jp@acrobiosystems.com

アクロバイオシステムズ株式会社
〒101-0051
東京都千代田区神田神保町1-32-8