Mouse Nectin-4 Protein, His Tag, low endotoxin (MALS verified)

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製品番号/仕様
価格
数量
NE4-M52Ha-100ug
$340.00
NE4-M52Ha-1mg (500ug X 2)
$2570.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    NECTIN4, LNIR, PRR4, PVRL4

  • Source

    Mouse Nectin-4, His Tag (NE4-M52Ha) is expressed from human 293 cells (HEK293). It contains AA Gly 31 - Ser 347 (Accession # Q8R007-1).

    Predicted N-terminus: Gly 31

    Request for sequence
  • Molecular Characterization

    Nectin-4 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 36.2 kDa. The protein migrates as 38-43 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, Arginine, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    Nectin-4 SDS-PAGE

    Mouse Nectin-4, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Nectin-4 SEC-MALS

    The purity of Mouse Nectin-4, His Tag (Cat. No. NE4-M52Ha) is more than 90% and the molecular weight of this protein is around 35-55 kDa verified by SEC-MALS.

    Report
  • Bioactivity-BLI

     Nectin-4 BLI

    Loaded Mouse Nectin-4, His Tag (Cat. No. NE4-M52Ha) on NTA Biosensor, can bind Human Nectin-1, Fc Tag (Cat. No. PV1-H5253) with an affinity constant of 48.8 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

    Protocol

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バックグランド

Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. Nectins are cell adhesion molecules that play a key role in various biological processes such as polarity, proliferation, differentiation and migration, for epithelial, endothelial, immune and neuronal cells, during development and adult life. Nectin-4 is a tumor-associated antigen in 50%, 49% and 86%o of breast, ovarian and lung carcinomas, respectively, mostly on tumors of bad prognosis. Its expression is not detected in the corresponding normal tissues.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Nectin-4

  • カテゴリ:

  • 市販の医薬品数:

    1 詳細

  • 治験医薬品数:

    28 詳細

  • 最新の開発ステージ:

    Approved

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