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製品詳細
Synonyms
PDCD1, PD1, CD279, SLEB2
Source
Canine PD-1, His Tag (PD1-C52H9) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Gly 168 (Accession # NP_001301026.1).
Predicted N-terminus: Leu 25
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 18.0 kDa. The protein migrates as 30-40 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 0.01 EU per μg by the LAL method / rFC method.
Purity
>90% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System
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データ表示
SDS-PAGE
Canine PD-1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).
SEC-MALS
The purity of Canine PD-1, His Tag (Cat. No. PD1-C52H9) is more than 95% and the molecular weight of this protein is around 25-35 kDa verified by SEC-MALS.
Report
Bioactivity-BLI
Loaded Canine PD-1, His Tag (Cat. No. PD1-C52H9) on HIS1K Biosensor, can bind Canine PD-L1, Fc Tag (Cat. No. PD1-C52H3) with an affinity constant of 85 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
Protocol
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最新の進展
医薬品開発の進捗- 英語名：
Programmed cell death protein 1
- カテゴリ：
- 市販の医薬品数：
22 詳細
- 治験医薬品数：
193 詳細
- 最新の開発ステージ：
Approved
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