Human PDE4A Protein, His Tag (MALS verified)

ユーザーレビュー
製品番号/仕様
価格
数量
PDA-H55H3-50ug
$360.00
PDA-H55H3-500ug
$2380.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    phosphodiesterase 4A, cAMP-specific 3', 5'-cyclic phosphodiesterase 4A

  • Source

    Human PDE4A Protein, His Tag (PDA-H55H3) is expressed from Baculovirus-Insect cells. It contains AA Pro 331 - Met 723 (Accession # P27815-1).

    Predicted N-terminus: Met

    Request for sequence
  • Molecular Characterization

    PDE4A Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 47.1 kDa. The protein migrates as 45-52 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Supplied as 0.2 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

お客様はこちらも閲覧

データ表示

  • SDS-PAGE

    PDE4A SDS-PAGE

    Human PDE4A Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    PDE4A SEC-MALS

    The purity of Human PDE4A Protein, His Tag (Cat. No. PDA-H55H3) is more than 95% and the molecular weight of this protein is around 48-68 kDa verified by SEC-MALS.

    Report
  • Bioactivity

    Measured by its ability to convert cAMP to 5'AMP. The specific activity is >140,000 pmol/min/μg (QC tested).

    Protocol

ユーザーレビュー
コメントを投稿

バックグランド

cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A) is an enzyme that in humans is encoded by the PDE4A gene. It belongs to the PDE family who hydrolyze 3′-5′-cyclic adenosine monophosphate (cyclic AMP) to 5′-adenosine monophosphate (AMP). PDE enzyme family plays a pivotal role in regulating levels of the second messenger cAMP. Consequently, PDE4 inhibitors have been investigated as a therapeutic strategy to enhance cAMP signaling in a broad range of diseases, including several types of cancers, as well as in various neurologic, dermatological, and inflammatory diseases.

最新の進展

 
お問い合わせ
医薬品候補ライセンス
他の関連情報
  • 製品情報
  • 製品詳細
  • お客様はこちらも閲覧
  • データ表示
  • ユーザーレビュー
  • 背景
お問い合わせ

お問い合わせ
グローバル:+1 800-810-0816(Toll Free)

メールアドレス
order.jp@acrobiosystems.com

アクロバイオシステムズ株式会社
〒101-0051
東京都千代田区神田神保町1-32-8