Mouse & Human TNFR2 / CD120b / TNFRSF1B Protein, His Tag, low endotoxin (MALS verified)

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製品番号/仕様
価格
数量
TN2-M52H3-50ug
$320.00
TN2-M52H3-1mg (500ug X 2)
$2570.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    TNFRSF1B, CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR

  • Source

    Mouse & Human TNFR2 Protein, His Tag (TN2-M52H3) is expressed from human 293 cells (HEK293). It contains AA Val 23 - Ala 120 (Mouse TNFR2) & Cys 120 - Thr 201(Human TNFR2) (Accession # P25119 & P20333-1).

    Predicted N-terminus: Val 23

    Request for sequence
  • Molecular Characterization

    TNFR2 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 21.6 kDa. The protein migrates as 30-33 kDa and 35-37 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    TNFR2 SDS-PAGE

    Mouse & Human TNFR2 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    TNFR2 SEC-MALS

    The purity of Mouse & Human TNFR2 Protein, His Tag (Cat. No. TN2-M52H3) is more than 95% and the molecular weight of this protein is around 22-32 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     TNFR2 ELISA

    Immobilized Mouse TNF-alpha Protein, Fc Tag (Cat. No. TNA-M5257) at 5 μg/mL (100 μL/well) can bind Mouse / Human TNFR2 Protein, His Tag (Cat. No. TN2-M52H3) with a linear range of 0.01-1.25 μg/mL (QC tested).

    Protocol

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バックグランド

TNFR2 (tumor necrosis factor receptor superfamily member 1B) is a receptor with high affinity for TNFSF2/TNF-alpha. It has a much lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. TNFR2 mediates most of the metabolic effects of TNF-alpha.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Tumor necrosis factor receptor superfamily member 1B

  • カテゴリ:

  • 市販の医薬品数:

    1 詳細

  • 治験医薬品数:

    8 詳細

  • 最新の開発ステージ:

    Approved

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