Cynomolgus Transferrin R / CD71 Protein, Fc Tag, low endotoxin (MALS verified)

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製品番号/仕様
価格
数量
TFR-C5263-100ug
$355.00
TFR-C5263-1mg
$2695.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    CD71, TFRC, TFR, sTfR, TfR1, Trfr, T9, p90

  • Source

    Cynomolgus Transferrin R Protein, Fc Tag (TFR-C5263) is expressed from human 293 cells (HEK293). It contains AA Cys 89 - Phe 760 (Accession # G8F602-1).

    Predicted N-terminus: Pro

    Request for sequence
  • Molecular Characterization

    Transferrin R Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the N-terminus.

    The protein has a calculated MW of 101.6 kDa. The protein migrates as 95-110 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    Transferrin R SDS-PAGE

    Cynomolgus Transferrin R Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Transferrin R SEC-MALS

    The purity of Cynomolgus Transferrin R Protein, Fc Tag (Cat. No. TFR-C5263) is more than 95% and the molecular weight of this protein is around 195-240 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     Transferrin R ELISA

    Immobilized Human Transferrin Protein, His Tag (Cat. No. TRN-H52H3) at 5 μg/mL (100 μL/well) can bind Cynomolgus Transferrin R Protein, Fc Tag (Cat. No. TFR-C5263) with a linear range of 0.2-16 ng/mL (QC tested).

    Protocol
  • Bioactivity-SPR

     Transferrin R SPR

    Cynomolgus Transferrin R Protein, Fc Tag (Cat. No. TFR-C5263) captured on Protein A Chip can bind Rhesus macaque Transferrin Protein, His Tag (Cat. No. TRN-R52H3) with an affinity constant of 0.795 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

    Protocol

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バックグランド

CD antigen CD71 is also known as Transferrin receptor protein 1, TfR, sTfR, p90, TfR1, Trfr, which belongs to the peptidase M28 family and M28B subfamily. CD71 /TFR contains one PA (protease associated) domain. CD71 / TfR1 is required for iron delivery from transferrin to cells. CD71 is a potential new target in cases of human leukomia & lymphoma. CD71 /TFRC / TfR has been shown to interact with GABARAP and HFE.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Transferrin receptor protein 1

  • カテゴリ:

  • 市販の医薬品数:

    1 詳細

  • 治験医薬品数:

    15 詳細

  • 最新の開発ステージ:

    Approved

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