Human TSLP Protein, Fc Tag, low endotoxin (MALS verified)

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製品番号/仕様
価格
数量
TSP-H5253-100ug
$385.00
TSP-H5253-1mg
$2310.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    TSLP

  • Source

    Human TSLP Protein, Fc Tag (TSP-H5253) is expressed from human 293 cells (HEK293). It contains AA Tyr 29 - Gln 159 (Accession # Q969D9-1).

    Predicted N-terminus: Tyr 29

    Request for sequence
  • Molecular Characterization

    TSLP Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 41.4 kDa. The protein migrates as 35-38 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    TSLP SDS-PAGE

    Human TSLP Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    TSLP SEC-MALS

    The purity of Human TSLP Protein, Fc Tag (Cat. No. TSP-H5253) is more than 90% and the molecular weight of this protein is around 85-110 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     TSLP ELISA

    Immobilized Human TSLP Protein, Fc Tag (Cat. No. TSP-H5253) at 5 μg/mL (100 μL/well) can bind Biotinylated Human TSLP R Protein, Fc,Avitag (Cat. No. TSR-H82F3) with a linear range of 0.06-4 ng/mL (QC tested).

    Protocol
  •  TSLP ELISA

    Immobilized Human TSLP Protein, Fc Tag (Cat. No. TSP-H5253) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human TSLP Antibody, Human IgG2 with a linear range of 0.06-8 ng/mL (Routinely tested).

    Protocol
  • Bioactivity-SPR

     TSLP SPR

    Human TSLP R, Fc Tag (Cat. No. TSR-H525a) immobilized on CM5 Chip can bind Human TSLP Protein, Fc Tag (Cat. No. TSP-H5253) with an affinity constant of 47.2 pM as determined in a SPR assay (Biacore 8K) (Routinely tested).

    Protocol

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バックグランド

Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5). Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Thymic stromal lymphopoietin

  • カテゴリ:

  • 市販の医薬品数:

    1 詳細

  • 治験医薬品数:

    29 詳細

  • 最新の開発ステージ:

    Approved

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