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A-Z
> Enzymes
Enzymes are catalysts in organisms that regulate chemical reactions without undergoing changes themselves. They are important biological targets for drug development, offering unique opportunities for drug design. Enzyme inhibitors play a crucial role in developing oral therapeutic agents used in clinical practice.
ACROBiosystems offers a range of target enzyme products for drug development. These include targets in adenosinergic pathways, matrix metalloproteinases, lysosomal proteases, and kinases. These products support the development of drugs and therapies targeting these enzymes.
Matrix metalloproteinases
Cathepsins
Coagulation factors
ADAM proteases
Others
Tyrosine kinase
Receptor tyrosine kinase
Serine/threonine-protein kinase
| Transglutaminases | Protein Arginine Deiminase | PADI2 PADI3 PADI6 |
| Ubiquitin Related Proteins | CBLB Elongin B & Elongin C & VHL UBE1 UCH-L1 UCH-L3 RNF43 | |
| Oxidoreductases | IDH1 TDO2 Xanthine dehydrogenase | |
| Hydrolases | Angiogenin beta-Galactosidase-1 beta-Glucuronidase/GUSB Glucosylceramidase Matriptase PH20 Plasma Kallikrein/KLKB1 Prostatic Acid Phosphatase | |
| Phosphatase | PTPRD | |
| Carbonic Anhydrase | Carbonic Anhydrase II Carbonic Anhydrase IX Carbonic Anhydrase XII | |
| Others | Plexin B1 Plexin B2 GAS6 | |
| Product | Human Cathepsin B proteases / CTSB Protein, His Tag (active enzyme)(Cat.No. CTB-H5222) |
| Substrate | Fluorogenic peptide substrate Z-LR-AMC |
| Enzyme Activity (pmol/min/μg) |
> 2500 |
| Product | Human KRAS (2-185,G12C) Protein, His Tag (active enzyme)(Cat.No. KRS-H51H3) |
| Substrate | GTPase-Glo test kras activity |
| Enzyme Activity | GTP≤85% |
Tool enzymes, including nucleic acid enzymes, have diverse functions like restriction, polymerization, ligation, modification, and cleavage. They efficiently recognize specific sequences and enable the manipulation and analysis of nucleic acids. These enzymes are widely used to detect and study biologically active molecules.
ACROBiosystems offers CAS nucleases, including universal nucleases, CAS9, and CAS12a, for cell and gene engineering, as well as regulatory safety monitoring of biological products.
ACROBiosystems also provides tool enzymes for antibody analysis, aiding in antibody fragmentation, glycosylation analysis, and exploring the relationship between antibody structure and function. These tools contribute to the development and quality control of biopharmaceuticals.
| Type | Molecular | Cat. No. | Description |
|---|---|---|---|
| GENIUS™ Nuclease | Nuclease HOT | BEE-N3116 | GENIUS™Nuclease DMF Filed |
| Nuclease HOT | NUE-S5119 | GENIUS™ Nuclease, premium grade | |
| Nuclease HOT | GMP-NUES19 | GMP GENIUS™Nuclease DMF Filed | |
| Cas Enzyme | cas9 | CA9-S5149 | GENPower™ NLS-Cas9 Nuclease (MALS verified) |
| Cas12a | CAA-L5140 | GENPower™ NLS-Cas12a Nuclease (MALS verified) | |
| Cas12a | CAA-L5149 | NLS-Cas12a Nuclease (MALS verified) |
| Type | Molecular | Cat. No. | Description | Application |
|---|---|---|---|---|
| Protease | 3C(HRV) | 3CC-N3133 | HRV-3C Protease Cleavage Enzyme, GST Tag (active enzyme) | HRV-3C removes affinity tag from fusion protein. |
| Enzymes for Antibody Characterization | IdeS | IDS-S5143 | IdeS (20U/μl) | IdeS specifically cleaves IgGs below the hinge region into F(ab´)2 and Fc fragments. |
| SpeB | SPB-S5115 | SpeB (40U/μl) | SpeB digests IgG to generate Fab and Fc fragments. | |
| Endo H | ENH-S5116 | Endo H (500U/μl) | Endo H cleaves asparagine-linked (N-linked) hybrid or high mannose oligosaccharides but not complex oligosaccharides. | |
| EndoS | ENS-S5143 | Endo S (200U/μl) | EndoS preferentially cleaves complex oligosaccharides and does not cleave asparagine-linked (N-linked) hybrid or high mannose oligosaccharides. |
During mRNA synthesis, modifications are employed to enhance translation efficiency, stability, and prevent degradation. These modifications involve capping the 5' end and appending a poly(A) tail at the 3' end of mRNA. ACROBiosystems offers enzyme products that facilitate mRNA synthesis and modification. These enzymes are of high purity, possess activity, and are free from contaminants. They effectively tackle challenges associated with capping efficiency, poly(A) tail sequences, mRNA stability, and cell delivery.
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