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> Neuroscience Frontier Tools Selection
With the rapid advancements in neuroscience, researchers are uncovering the complexities of the nervous system, particularly in studies on neurodevelopmental disorders, neurodegenerative diseases (e.g., Parkinson's disease, Alzheimer's disease), and brain injury repair mechanisms. However, due to the complexity of the nervous system, traditional 2D cell and animal models fall in fully simulating the human brain's microenvironment and dynamic changes. As a result, scientists are turning to more advanced tools and models to explore neural functions and pathological mechanisms.
To support this, we offer a range of cutting-edge neuroscience tools, including iPSC-Derived neural cells, brain organoids, and microelectrode array (MEA) services. These products and services provide advanced platforms for research in neurodevelopment, neurodegenerative diseases, drug screening, and neural network activity analysis, enabling researchers to delve deeper into the neuroscience.
Our products include iPSC-Derived neural progenitor cells and iPSC-Derived dopamine neurons. Neural progenitor cells possess multipotent differentiation capacity, efficiently generating various types of neurons and support cells, while dopamine neurons accurately model the function of human substantia nigra dopamine neurons. These cell products offer high efficiency and consistency, ideal for drug screening, toxicology studies, and disease modeling.
Human iPSC-Derived Neural Progenitor Cells (Cat. No. CIPC-NWC001) have the ability to differentiate into dopaminergic neurons (Cat. No. CIPC-DWC001), characterized by immunocytochemistry using well-known markers such as TH and MAP2.
| Cat. No. | Product Description | Donor Status |
|---|---|---|
| CIPC-NWC001 | Human iPSC-Derived Neural Progenitor Cells | Healthy |
| CIPC-NDC001 | Human iPSC-Derived Neural Progenitor Cells (Parkinson's disease) | Parkinson's disease |
| CIPC-DWC001 | Human iPSC-Derived Dopamine Neurons | Healthy |
| CIPC-DDC001 | Human iPSC-Derived Dopamine Neurons (Parkinson's disease) | Parkinson's disease |
iPSC-Derived brain organoids possess similar structure and electrophysiological properties to human brain, making them valuable tools for neuropharmacological screening, disease modeling, AAV vector screening, and neurodevelopmental research. We offer cerebral organoid and midbrain organoid products to provide researchers with robust experimental models.
The midbrain organoids (Cat. No. CIPO-MBWL001K) exhibit high expression of TH (dopaminergic neurons), MAP2 (mature neurons), as well as FOXA2 and OTX2 (dopaminergic progenitor cells) on day 37.
| Cat. No. | Product Description |
|---|---|
| CIPO-BWL001K | Ready-to-use Human iPSC-Derived Cerebral Organoids |
| CIPO-BWL002K | Ready-to-use Human iPSC-Derived Mature Cerebral Organoids 100 days+ |
| CIPO-MBWL001K | Ready-to-use Human iPSC-Derived Midbrain Organoids |
| CIPO-BWL001KC | Cryopreserved Human iPSC-Derived Cerebral Organoids |
| RIPO-BWM001K | Human iPSC-Derived Cerebral Organoid Differentiation Kit |
| RIPO-BWM003 | Human iPSC-Derived Cerebral Organoid Maturation and Maintenance Kit |
| RIPO-BWM006 | Cerebral Organoid Cryopreservation Kit |
Microelectrode Array (MEA) is an advanced electrophysiological technology that allows real-time, non-invasive recording of cellular electrical signals, enabling long-term monitoring of neuronal network activity and capturing complex signal patterns. This technology is suitable for high-throughput drug screening, neurotoxicity assessment, and drug efficacy testing, providing reliable data for drug development. We offer industry-leading MEA detection services for electrophysiological activity in both 2D cells and organoids.
Spontaneous firing activity of Human iPSC-Derived Dopamine Neurons (Cat. No. CIPC-DDC001) on MEA plates. The heatmap video and raster plot illustrate regular network burst patterns, confirming successful neuron culture and strong functional connectivity, indicating the product's suitability for neurophysiological research.
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