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Your Position: ホーム > Integrin alpha 3 beta 1

Integrin alpha 3 beta 1

概要

Name:Integrin alpha 3/beta 1
Target Synonym:
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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製造番号 種類 製品説明 構造 純度 特徴
IT1-R53Wb Rat Rat Integrin alpha 3 beta 1 (ITGA3&ITGB1) Heterodimer Protein, His Tag&Tag Free (MALS verified)
IT1-R53Wb-structure
IT1-R53Wb-sds
IT1-H52Wc Human Human Integrin alpha 3 beta 1 (ITGA3&ITGB1) Heterodimer Protein, His Tag&Tag Free (MALS verified)
IT1-H52Wc-structure
IT1-H52Wc-sds
ACRO Quality

生物活性データの一部

IT1-H52Wc-SPR
Integrin alpha 3 beta 1 SPR

Human Laminin 511 Protein, premium grade (Cat. No. LA8-H5283) captured on Protein A Chip can bind Human ITGA3&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52Wc) with an affinity constant of 30.8 nM as determined in SPR assay (Biacore 8K) (Routinely tested).

Protocol
IT1-H52Wc-BLI
Integrin alpha 3 beta 1 BLI

Loaded Human Laminin 511 Protein, premium grade (Cat. No. LA8-H5283) on Protein A Biosensor, can bind Human ITGA3&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52Wc) with an affinity constant of 8.6 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

Integrin alpha 3 beta 1,ITGA3&ITGB1

Background

Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
VAX-014 VAX-014 Phase 1 Clinical Vaxiion Therapeutics Llc Solid tumours Details

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