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Your Position: ホーム > JAK1

JAK1

概要

Name:Tyrosine-protein kinase JAK1
Target Synonym:JAK1B,Tyrosine-protein kinase JAK1,JAK1,Janus Kinase 1,JAK1A,EC 2.7.10.2,JAK-1,JTK3,EC:2.7.10.2,EC 2.7.10
Number of Launched Drugs:8
Number of Drugs in Clinical Trials:45
Lastest Research Phase:Approved

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製造番号 種類 製品説明 構造 純度 特徴
JA1-H5547 Human Human JAK1 Protein, His Tag
JA1-H5547-structure
JA1-H5547-sds
ACRO Quality

Synonym Name

JAK1,JAK-1,JAK1A,JAK1B,Jak1

Background

JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (?c) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body

Clinical and Translational Updates

公開薬物情報

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Filgotinib Maleate G-146034-101; GS-6034; G-146034; GLPG-0634 Approved Galapagos Nv Jyseleca EU Arthritis, Rheumatoid Galapagos Nv 2020-09-24 Non-radiographic axial spondyloarthritis; Inflammatory Bowel Diseases; Myositis; Immunoglobulin G4-Related Disease; Lupus Erythematosus, Cutaneous; Arthritis, Rheumatoid; Sjogren's Syndrome; Kidney Diseases; Glomerulonephritis, Membranous; Arthritis, Juvenile; Lupus Nephritis; Colitis, Ulcerative; Arthritis, Psoriatic; Uveitis; Crohn Disease; Behcet Syndrome Details
Peficitinib ASP-015K; JNJ-54781532 Approved Astellas Pharma Inc Smyraf Japan Arthritis, Rheumatoid Astellas Pharma Inc 2019-03-29 Arthritis, Rheumatoid; Psoriasis; Colitis, Ulcerative Details
Momelotinib Dihydrochloride CYT-387; GS-0387; GSK-3070785 Approved Gilead Sciences Inc, Cytopia Pty Ltd Ojjaara, Omjjara United States Primary Myelofibrosis; Anemia Glaxosmithkline Llc, Glaxosmithkline Plc 2023-09-15 Polycythemia; Polycythemia Vera; Anemia; Neoplasms; Myeloproliferative Disorders; Pancreatic Intraductal Neoplasms; Primary Myelofibrosis; Carcinoma, Pancreatic Ductal; Splenomegaly; Thrombocythemia, Essential; Carcinoma, Non-Small-Cell Lung Details
Abrocitinib PF-4965842; PF-04965842 Approved Pfizer Inc Cibinqo, 希必可 United Kingdom Dermatitis, Atopic Pfizer Inc 2021-09-09 Psoriasis; Dermatitis, Atopic; Eczema; Skin Diseases, Genetic; Hypersensitivity; Hypersensitivity, Immediate; Prurigo; Hepatic Insufficiency; Granuloma Annulare; Pruritus; Food Hypersensitivity; Immune System Diseases; Skin Diseases; Skin Diseases, Eczematous; Dermatitis; Genetic Diseases, Inborn; Sarcoidosis; Kidney Diseases Details
Tofacitinib Citrate CP-690550; AC-1101; IMG 003; CGB-500; CP-690550-10; CKD-374; Tasocitinib; BI-764524 Approved Pfizer Inc Jakvinus, Xeljanz, 尚杰 United States Arthritis, Rheumatoid Pf Prism Cv 2012-11-06 Sarcoidosis, Pulmonary; Dry Eye Syndromes; Arthritis, Juvenile; Lung Diseases; Lung Diseases, Interstitial; Psoriasis; Lupus Erythematosus, Systemic; Granuloma Annulare; Colitis, Ulcerative; Arthritis, Psoriatic; Hepatic Insufficiency; Sarcoidosis; Granulomatous Disease, Chronic; Inflammation; Hidradenitis Suppurativa; Uveitis; Crohn Disease; Vitiligo; Plaque psoriasis; Dermatitis, Atopic; Eczema; Scleritis; Rejection of renal transplantation; Non-radiographic axial spondyloarthritis; Alopecia; Alopecia Areata; Gastrointestinal Diseases; Down Syndrome; Dermatomyositis; Lupus Erythematosus, Discoid; Sacroiliitis; Depression; Keratoconjunctivitis Sicca; Arthritis, Rheumatoid; Kidney Diseases; Spondylitis, Ankylosing; Sjogren's Syndrome; Coronavirus Disease 2019 (COVID-19); Spondylitis; Lupus Erythematosus, Cutaneous; Glioblastoma; Scleroderma, Systemic Details
Upadacitinib ABT-494 Approved Abbott Laboratories, Abbvie Inc Rinvoq, 瑞福 United States Arthritis, Rheumatoid Abbvie Inc 2019-08-16 Non-radiographic axial spondyloarthritis; Alopecia Areata; Giant Cell Arteritis; Arthritis, Rheumatoid; Spondylarthritis; Spondylitis, Ankylosing; Arthritis, Juvenile; Takayasu Arteritis; Lupus Erythematosus, Systemic; Colitis, Ulcerative; Arthritis, Psoriatic; Hidradenitis Suppurativa; Crohn Disease; Dermatitis, Atopic; Vitiligo Details
Baricitinib LY-3009104; INCB-028050 Approved Incyte Corp 艾乐明, Olumiant EU Arthritis, Rheumatoid Eli Lilly Nederland BV 2017-02-13 Diabetic Nephropathies; Lupus Nephritis; Lupus Erythematosus, Systemic; Psoriasis; Cholangitis, Sclerosing; Pyoderma; Coronavirus Infections; Severe Acute Respiratory Syndrome; Anhedonia; Polymyalgia Rheumatica; Skin Ulcer; Hepatic Insufficiency; Skin Diseases, Papulosquamous; Renal Insufficiency, Chronic; Wounds and Injuries; Lichen Planus, Oral; Dermatitis, Atopic; HIV Seropositivity; Coronavirus Disease 2019 (COVID-19); Diabetes Mellitus, Type 1; HIV Infections; Alopecia Areata; Myositis; Dermatomyositis; Pyoderma Gangrenosum; Depression; Nephritis; Infections; Arthritis, Rheumatoid; Graft vs Host Disease; Pemphigoid, Benign Mucous Membrane; Skin Diseases; Arthritis, Juvenile; Conjunctivitis; Liver Diseases Details
Ruxolitinib Phosphate INC-424; INCB-424; INCB-18424; RUX; INCB 018424 phosphate; INCB-018424 Approved Incyte Corp Jakafi, OPZELURA, Jakavi United States Primary Myelofibrosis Incyte Corp 2011-11-16 Anemia, Aplastic; Hyperplasia; Hepatomegaly; Lichen Planus; Leukemia, Myeloid, Chronic-Phase; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Prurigo; Primary Myelofibrosis; Pancytopenia; Cachexia; Coronavirus Infections; Carcinoma, Intraductal, Noninfiltrating; Prostatic Neoplasms; Thrombocytosis; Ectodermal Dysplasia; Psoriasis; Leukemia, Neutrophilic, Chronic; Splenomegaly; Carcinoma, Non-Small-Cell Lung; Eczema; Leukemia, T-Cell; Myelodysplastic-Myeloproliferative Diseases; Leukemia, Lymphocytic, Chronic, B-Cell; Vitiligo; Thrombocythemia, Essential; Dermatitis, Atopic; Breast Neoplasms; Carcinoma, Squamous Cell; Lichen Sclerosus et Atrophicus; Hidradenitis Suppurativa; Lymphoma, Non-Hodgkin; Lymphohistiocytosis, Hemophagocytic; Leukemia, Myeloid, Acute; Lymphoma; HIV Infections; Pancreatic Neoplasms; Graft vs Host Disease; beta-Thalassemia; Hodgkin Disease; Lupus Erythematosus, Discoid; Squamous Cell Carcinoma of Head and Neck; Alopecia Areata; Polycythemia Vera; Coronavirus Disease 2019 (COVID-1 Details

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Povorcitinib INCB-54707; INCB54707; INCB054707; INCB-054707 Phase 3 Clinical Incyte Corp Pruritus; Renal Insufficiency; Chronic Urticaria; Kidney Diseases; Asthma; Urticaria; Prurigo; Hidradenitis Suppurativa; Angioedema; Vitiligo Details
Brepocitinib PF-06700841-15; PF-6700841; PF-841; PF-06700841 Phase 3 Clinical Pfizer Inc Alopecia; Dermatomyositis; Alopecia Areata; Kidney Diseases; Lupus Erythematosus, Systemic; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Hidradenitis Suppurativa; Uveitis, Posterior; Crohn Disease; Dermatitis, Atopic; Vitiligo; Panuveitis Details
WXFL-10203614 WXFL-10203614 Phase 3 Clinical Wuxi Fuxin Pharmaceutical Research And Development Co Ltd, Wuxi Apptec Co Ltd Arthritis, Rheumatoid; Colitis, Ulcerative; Dermatitis, Atopic Details
TLL-018 TLL-018 Phase 3 Clinical Tll Pharmaceutical Llc Chronic Urticaria; Arthritis, Rheumatoid; Psoriasis; Lupus Erythematosus, Systemic; Urticaria; Colitis, Ulcerative; Dermatitis, Atopic; Plaque psoriasis Details
Tinengotinib TT-00420; TT 00420; TT00420 Phase 3 Clinical TransThera Sciences (Nanjing) Inc Biliary Tract Neoplasms; Solid tumours; Kidney Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma; Carcinoma, Transitional Cell; Urinary Bladder Neoplasms; Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms; Breast Neoplasms; Cholangiocarcinoma; Sarcoma; Thyroid Neoplasms; Gallbladder Neoplasms Details
LW-402 LW-402 Phase 3 Clinical Shanghai Longwood Biopharmaceuticals Co Ltd Arthritis, Rheumatoid; Vitiligo; Dermatitis, Atopic Details
LNK-01001 LNK001; LNK-207; EQ-121; LNK-01001; LNK01001; LNK-001 Phase 3 Clinical Lynk Pharmaceutical (Hangzhou) Co Ltd Non-radiographic axial spondyloarthritis; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Dermatitis, Atopic Details
Itacitinib INCB-039110-adipate; INCB-39110; INCB-039110; IBI-377 Phase 3 Clinical Incyte Corp Leukemia, Myeloid, Acute; Sarcoma, Synovial; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Hemic and Lymphatic Diseases; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Breast Neoplasms; Psoriasis; Thrombocytosis; Sarcoma; Leukemia, B-Cell; Primary Myelofibrosis; Colorectal Neoplasms; Asthma; Colitis, Ulcerative; Liposarcoma; Lymphoma; Lymphoma, Non-Hodgkin; Leukemia, Prolymphocytic, T-Cell; Lung Neoplasms; Lymphohistiocytosis, Hemophagocytic; Endometrial Neoplasms; Carcinoma, Hepatocellular; Myelodysplastic-Myeloproliferative Diseases; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Liposarcoma, Myxoid; Melanoma; Graft vs Host Disease; Leukemia; Leukemia, Myelogenous, Chronic; Lymphoma, B-Cell; Bronchiolitis Obliterans; Head and Neck Neoplasms; Cytokine Release Syndrome; Solid tumours; Chondrosarcoma; Leiomyosarcoma; Pruritus; Polycythemia Vera; Carcinoma, Renal Cell; Hematologic Neoplasms; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Myeloproliferative Disorders; Hodgkin Disease; N Details
PG-011 PG-011 Phase 2 Clinical Prime Gene Therapeutics Co Ltd Radiodermatitis; Epidermolysis Bullosa; Dermatitis; Rhinitis, Allergic; Prurigo; Eye Diseases; Dermatitis, Atopic; Vitiligo Details
WXSH-0150 WXSH-0150; TUL-01101 Phase 2 Clinical Zhuhai United Laboratories Co Ltd Arthritis, Rheumatoid; Dermatitis, Atopic Details
Elsubrutinib/Upadacitinib ABBV-599 Phase 2 Clinical Abbvie Inc Arthritis, Rheumatoid; Lupus Erythematosus, Systemic Details
NS-229 NS-229 Phase 2 Clinical Neurosearch As Eosinophilic Granulomatosis With Polyangiitis; Epilepsy Details
ATI-502 A-301; ATI-502; ATI-50002 Phase 2 Clinical Rigel Pharmaceuticals Inc Alopecia; Alopecia Areata; Dermatitis, Atopic Details
A-223 A-223; A223 Phase 2 Clinical Klus Pharma Inc Arthritis, Rheumatoid Details
TDM-180935 TDM-180935 Phase 2 Clinical Jiaxing TechnoDerma Medicines Inc Dermatitis, Atopic Details
AC-201 AC-201 Phase 2 Clinical Accro Bioscience (Suzhou) Co Ltd Lupus Erythematosus, Systemic; Psoriasis Details
VVN-461 VVN461e; VVN-461-e; VVN-461 Phase 2 Clinical VivaVision Biotech Inc Uveitis, Anterior; Uveitis; Inflammation; Postoperative inflammation Details
Fingolimod/Tofacitinib FMX-114 Phase 2 Clinical Vyne Therapeutics Inc Dermatitis, Atopic Details
QY201 QY-201; QY201 Phase 2 Clinical E-nitiate Biopharmaceuticals (Hangzhou) Co Ltd Alopecia Areata; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Prurigo; Dermatitis, Atopic Details
VC-005 VC-005 Phase 2 Clinical Jiangsu Vcare Pharmatech Co Ltd Inflammatory Bowel Diseases; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Joint Diseases; Colitis, Ulcerative; Dermatitis, Atopic; Vitiligo; Crohn Disease; Eczema Details
AZD-4604 AZD-4604 Phase 2 Clinical Astrazeneca Plc Asthma Details
ICP-332 ICP-332 Phase 2 Clinical InnoCare Pharma Ltd Psoriasis; Dermatitis, Atopic Details
ATI-1777 Phase 2 Clinical Aclaris Therapeutics Inc Dermatitis, Atopic Details
ATI-501 A-201; ATI-501; ATI-50001 Phase 2 Clinical Rigel Pharmaceuticals Inc Alopecia Details
CS-12192 CS12192 Phase 1 Clinical Shenzhen Chipscreen Biosciences Co Ltd Enteritis; Alopecia Areata; Graft vs Host Disease; Autoimmune Diseases; Multiple Sclerosis; Lupus Erythematosus, Systemic; Dermatitis, Atopic Details
FZJ-003 FZJ-003 Phase 1 Clinical Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd Arthritis, Rheumatoid; Dermatitis, Atopic Details
VR-588 VR-588; KN-002; KN-002 (Kinaset Therapeutics/Vectura) Phase 1 Clinical Vectura Ltd Asthma Details
GLPG-3121 GLPG-3121 Phase 1 Clinical Galapagos Nv Details
Tofacitinib oral (Biora Therapeutics) BT-600; PGN-600 Phase 1 Clinical Progenity Inc Colitis, Ulcerative Details
Tofacitinib citrate (TWi Biotechnology) AC-1101; IMG 003 Phase 1 Clinical Twi Biotechnology Inc Granuloma Annulare Details
GDC-0214 RG-6151; GDC-0214 Phase 1 Clinical Genentech Inc Asthma Details
BHV-8000 TLL-041; TLL041 Phase 1 Clinical Hangzhou Highlightll Pharmaceutical Co Ltd Multiple Sclerosis; Alzheimer Disease; Parkinson Disease; Central Nervous System Diseases Details
AQ-280 AQ-280 Phase 1 Clinical Aqilion AB Eosinophilic Esophagitis Details
PG-018 PG-018 Phase 1 Clinical Prime Gene Therapeutics Co Ltd Nephrosis; Glomerulonephritis, Membranous Details
MAX-40070 MAX-40070 Phase 1 Clinical Maxinovel Pty Ltd Alopecia Areata Details
H-018 H018; H-018 Phase 1 Clinical Jiangsu Carephar Pharmaceutical Co Ltd, Nanjing Shenzhou Jiamei Pharmaceutical Co Ltd Arthritis, Rheumatoid Details
TT-00420/Atezolizumab Phase 1 Clinical TransThera Sciences (Nanjing) Inc Gastrointestinal Neoplasms Details
LBG-1600M Phase 1 Clinical Suzhou Longbotai Pharmaceutical Co Ltd Dermatitis, Atopic Details
LNK-01002 LNK01002 Phase 1 Clinical Lynk Pharmaceutical (Hangzhou) Co Ltd Hematologic Neoplasms; Polycythemia Vera; Myeloproliferative Disorders; Primary Myelofibrosis; Leukemia, Myeloid, Acute Details
NIP-046 NIP-046 Phase 1 Clinical National Institutes Of Pharmaceutical Research And Development Co Ltd Chronic Urticaria; Arthritis, Rheumatoid Details
Tofacitinib controlled release (Triastek) T-21; T21 Clinical Triastek Inc Colitis, Ulcerative Details

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