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IFN-alpha 1

概要

Name:Interferon-alpha/beta receptor alpha chain
Target Synonym:IFNBR,IFN-Alpha-REC,Beta-Type Antiviral Protein,IFNAR,Cytokine Receptor Class-II Member 1,Interferon Receptor 1,IFNAR1,Interferon Alpha/Beta Receptor 1,Interferon Alpha And Beta Receptor Subunit 1,Type I Interferon Receptor 1,Interferon (Alpha, Beta And Omega) Receptor 1,Alpha-Type Antiviral Protein,IFN-Alpha/Beta Receptor 1,AVP,Interferon-Beta Receptor 1,IFRC,IFN-R-1,CRF2-1,Cytokine Receptor Family 2 Member 1,Interferon-Alpha/Beta Receptor Alpha Chain
Number of Launched Drugs:5
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Approved

製品リスト製品比較と製品注文

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製造番号 種類 製品説明 構造 純度 特徴
IFA-H5258 Human Human IFN-alpha 1 Protein, Fc Tag (MALS verified)
IFA-H5258-structure
IFA-H5258-sds
IFA-H52H9 Human Human IFN-alpha 1 Protein, His Tag
IFA-H52H9-structure
IFA-H52H9-sds
IFA-M52H3 Mouse Mouse IFN-alpha 1 Protein, His Tag
IFA-M52H3-structure
IFA-M52H3-sds
ACRO Quality

生物活性データの一部

IFA-H5258-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IFN-alpha / beta R1, His Tag (Cat. No. IF1-H5225) on NTA Biosensor, can bind Human IFN-alpha 1, Fc Tag (Cat. No. IFA-H5258) with an affinity constant of 11.3 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

IFA-H5258-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IFNAR2, His Tag (Cat. No. IF2-H5224) on HIS1K Biosensor, can bind Human IFN-alpha 1, Fc Tag (Cat. No. IFA-H5258) with an affinity constant of 2.67 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

カスタマーレビュー

Synonym Name

IFN-alpha 1,IFNA1,IFNalpha 1,IFN-alpha-1,LeIF D

Background

Interferon alpha-1 is also known as IFN-alpha-1/13, Interferon alpha-D, LeIF D and IFNA1, belongs to the alpha / beta interferon family. Interferons alpha-1 and alpha-13 have identical protein sequences. Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. IFN-alpha can either suppress or promote the development of autoimmune diabetes. It is likely that IFN-alpha plays a complex role in the etiology of type 1 diabetes.

Clinical and Translational Updates

公開薬物情報

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Recombinant human interferon α2b biosimilar (Zhejiang Hansheng) Approved Zhejiang Hansheng Pharmaceutical Co Ltd Of Beisheng Pharma 莱福隆 Mainland China Neoplasms; Virus Diseases Zhejiang Hansheng Pharmaceutical Co Ltd Of Beisheng Pharma 1999-01-01 Neoplasms; Virus Diseases Details
Recombinant human interferon alfa-2b (Harbin Pharmaceutical Group Bioengineering) Approved Harbin Pharmaceutical Group Holding Co Ltd 里亚美, 利分能 Mainland China Condylomata Acuminata; Varicella Zoster Virus Infection; Leukemia, Hairy Cell; Leukemia, Myelogenous, Chronic; Lymphoma, Non-Hodgkin; Multiple Myeloma; Hepatitis, Viral, Human Harbin Pharmaceutical Group Pharmaceutical Co Ltd 1996-01-01 Leukemia, Myelogenous, Chronic; Leukemia, Hairy Cell; Varicella Zoster Virus Infection; Multiple Myeloma; Hepatitis, Viral, Human; Lymphoma, Non-Hodgkin; Condylomata Acuminata Details
Recombinant human interferon α2b biosimilar (Harbin High-Tech White Swan Pharmaceutical) Approved Harbin High-Tech Group Baitian'Er Pharmaceutical Co Ltd Fu Li Sheng Leukemia, Hairy Cell; Hepatitis; Multiple Myeloma; Leukemia, Myeloid, Chronic-Phase; Lymphoma, Non-Hodgkin; Herpes Zoster; Condylomata Acuminata Details
Interferon beta (Toray/Daiichi Sankyo) DL-8234 Approved Toray Industries Inc Feron Japan Hepatitis C; Astrocytoma; Glioblastoma; Hepatitis B; Medulloblastoma; Melanoma null 1985-04-01 Medulloblastoma; Glioblastoma; Hepatitis B; Hepatitis C; Astrocytoma; Melanoma Details
Anifrolumab MEDI-546; MDX-1333 Approved Medimmune Llc, Medarex SAPHNELO United States Lupus Erythematosus, Systemic Astrazeneca Ab 2021-07-30 Polymyositis; Atherosclerosis; Scleroderma, Systemic; Sjogren's Syndrome; Lupus Erythematosus, Cutaneous; Lupus Nephritis; Lupus Erythematosus, Systemic; Cardiovascular Diseases; Vitiligo Details

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Recombinant human interferon α2b biosimilar (West China Hospital) West China Hospital Of Sichuan University Details

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