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Your Position: ホーム > ZNRF3

ZNRF3

概要

Name:E3 ubiquitin-protein ligase ZNRF3
Target Synonym:
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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製造番号 種類 製品説明 構造 純度 特徴
ZN3-H52H3 Human Human ZNRF3 protein, His Tag (MALS verified)
ZN3-H52H3-structure
ZN3-H52H3-sds
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生物活性データの一部

ZN3-H52H3-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human ZNRF3, His Tag (Cat. No. ZN3-H52H3) on HISIK Biosensor, can bind Human R-Spondin 3 Protein, Fc Tag with an affinity constant of 16.05 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

Protocol
ZN3-H52H3-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human R-Spondin 3 Protein, Fc Tag on Protein A Biosensor, can bind Human ZNRF3, His Tag (Cat. No. ZN3-H52H3) with an affinity constant of 10.9 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

ZNRF3,  Zinc/RING finger protein 3, RING-type E3 ubiquitin transferase ZNRF3, RING finger protein 203, KIAA1133, RNF203

Background

The transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) is a negative feedback regulator of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6 and acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
SZN-043 SZN-043; SZN-043双特异性融合蛋白; SZN-043 Bispecific Fusion Protein; SZN-043 (RSPO模拟物) Phase 1 Clinical Surrozen Inc Hepatitis, Alcoholic; Liver Cirrhosis Details

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