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CD45

概要

Name:Leukocyte common antigen
Target Synonym:PTPRC,T200,CD45,Protein Tyrosine Phosphatase, Receptor Type C,CD45 Antigen,L-CA,Protein Tyrosine Phosphatase, Receptor Type, C Polypeptide,Receptor-Type Tyrosine-Protein Phosphatase C,T200 Leukocyte Common Antigen,Leukocyte Common Antigen,T200 Glycoprotein,EC 3.1.3.48,CD45R,GP180,B220,LCA,LY5,Leukocyte Common Antigens,Protein Tyrosine Phosphatase Receptor Type C,EC:3.1.3.48
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 3 Clinical

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製造番号 種類 製品説明 構造 純度 特徴
FABm007-06 Mouse PerCP-Cy5.5 Labeled Monoclonal Anti-Human CD45 Antibody, Mouse IgG2a
CD5-H82E8 Human Biotinylated Human CD45 / PTPRC Protein, His,Avitag™
CD5-H82E8-structure
CD5-H82E8-sds
CD5-H5259 Human Human CD45 / PTPRC Protein, Llama IgG2b Fc Tag, low endotoxin
CD5-H5259-structure
CD5-H5259-sds
CD5-H52H8 Human Human CD45 / PTPRC protein, His Tag
CD5-H52H8-structure
CD5-H52H8-sds
CD5-H82E7 Human Biotinylated Human CD45 / PTPRC protein, His,Avitag™ (MALS verified)
CD5-H82E7-structure
CD5-H82E7-sds
ACRO Quality

生物活性データの一部

FABm007-06-Cell-based assay
CD45 FACS

Flow cytometric analysis of Human peripheral blood lymphocytes respectively staining with PerCP-CY5.5-Labeled Anti-Human CD45 Antibody, mouse IgG2a (AIRFS225-240625F1-Bulk) at 1:20 dilution (5 μL of the antibody stock solution corresponds to labeling of 2.5e5 cells in a final volume of 100 µL), compared with isotype control antibody. PerCP-CY5.5 signal was used to evaluate the binding activity (QC tested).

Protocol
CD5-H82E7-BLI
Biotinylated Human CD45, His,Avitag (Cat. No. ) MALS images

The purity of Biotinylated Human CD45, His,Avitag (Cat. No. CD5-H82E7) is more than 85% and the molecular weight of this protein is around 180-210 kDa verified by SEC-MALS.

Report
  • Background
    CD45 is a receptor protein tyrosine phosphatase, also known as Ly-5 or leukocyte common antigen. CD45 mainly involves in the initiation of T cell receptor signaling by controlling the activation of the Src family protein-tyrosine kinases Lck and Fyn. CD45 deficiency causes in T- and B-lymphocyte dysfunction in the form of severe combined immune deficiency. It also takes a significant role in autoimmune diseases and cancer as well as in infectious diseases including fungal infections.
  • Clinical and Translational Updates
      

  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

カスタマーレビュー

Synonym Name

CD45,PTPRC,L-CA,T200

Background

CD45 is a receptor protein tyrosine phosphatase, also known as Ly-5 or leukocyte common antigen. CD45 mainly involves in the initiation of T cell receptor signaling by controlling the activation of the Src family protein-tyrosine kinases Lck and Fyn. CD45 deficiency causes in T- and B-lymphocyte dysfunction in the form of severe combined immune deficiency. It also takes a significant role in autoimmune diseases and cancer as well as in infectious diseases including fungal infections.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Immunomodulatory progenitor cell therapy (Celixir) Phase 3 Clinical Celixir Endomyocardial Fibrosis; Cardiomyopathies Details
I-131-Apamistamab 131IBC8; BC8-I-131; BC-8 Phase 3 Clinical Fred Hutchinson Cancer Research Center Leukemia, Myeloid, Acute; Sezary Syndrome; Neoplasms, Gonadal Tissue; Waldenstrom Macroglobulinemia; Lymphoma; Burkitt Lymphoma; Lymphoma, Non-Hodgkin; Intraocular Lymphoma; Lymphoma, T-Cell; Pancytopenia; Lymphoma, T-Cell, Cutaneous; Anemia, Sideroblastic; Lymphoma, Large-Cell, Anaplastic; Leukemia, T-Cell; Leukemia, Large Granular Lymphocytic; Leukemia, Lymphocytic, Chronic, B-Cell; Mycosis Fungoides; Lymphoma, Large-Cell, Immunoblastic; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Hematopoietic stem cell transplantation (HSCT); Leukemia; Neoplastic Cells, Circulating; Leukemia, Hairy Cell; Anemia, Refractory, with Excess of Blasts; Hodgkin Disease; Lymphoma, T-Cell, Peripheral; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Lymphomatoid Granulomatosis; Lymphoma, Large B-Cell, Diffuse; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Follicular; Lymphoma, Mantle-Cell Details
At 211 MAb BC8-B10 Phase 2 Clinical Fred Hutchinson Cancer Research Center Neoplasms Details
Immunomodulatory progenitor cell therapy (Celixir) Phase 3 Clinical Celixir Endomyocardial Fibrosis; Cardiomyopathies Details
I-131-Apamistamab 131IBC8; BC8-I-131; BC-8 Phase 3 Clinical Fred Hutchinson Cancer Research Center Leukemia, Myeloid, Acute; Sezary Syndrome; Neoplasms, Gonadal Tissue; Waldenstrom Macroglobulinemia; Lymphoma; Burkitt Lymphoma; Lymphoma, Non-Hodgkin; Intraocular Lymphoma; Lymphoma, T-Cell; Pancytopenia; Lymphoma, T-Cell, Cutaneous; Anemia, Sideroblastic; Lymphoma, Large-Cell, Anaplastic; Leukemia, T-Cell; Leukemia, Large Granular Lymphocytic; Leukemia, Lymphocytic, Chronic, B-Cell; Mycosis Fungoides; Lymphoma, Large-Cell, Immunoblastic; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Hematopoietic stem cell transplantation (HSCT); Leukemia; Neoplastic Cells, Circulating; Leukemia, Hairy Cell; Anemia, Refractory, with Excess of Blasts; Hodgkin Disease; Lymphoma, T-Cell, Peripheral; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Lymphomatoid Granulomatosis; Lymphoma, Large B-Cell, Diffuse; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Follicular; Lymphoma, Mantle-Cell Details
At 211 MAb BC8-B10 Phase 2 Clinical Fred Hutchinson Cancer Research Center Neoplasms Details

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