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Your Position: ホーム > CD69

CD69

概要

Name:DNA (cytosine-5)-methyltransferase 1
Target Synonym:Dnmt1,AIM,MCMT,DNA methyltransferase HsaI,DNA Methyltransferase 1,CXXC-Type Zinc Finger Protein 9,DNA MTase HsaI,M.HsaI,CXXC9,EC:2.1.1.37,DNA (Cytosine-5-)-Methyltransferase 1,DNMT,DNA (Cytosine-5)-Methyltransferase 1,EC 2.1.1.37,ADCADN,HSN1E
Number of Launched Drugs:5
Number of Drugs in Clinical Trials:9
Lastest Research Phase:Approved

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CD9-H5222 Human Human CD69 / CLEC2C Protein, His Tag
CD9-H5222-structure
CD9-H5222-sds
ACRO Quality

Synonym Name

CD69,CLEC2C,AIM,BL-AC/P26,EA1,GP32/28,MLR-3

Background

Early activation antigen CD69 is also known as C-type lectin domain family 2 member C (CLEC2C), Activation inducer molecule (AIM), Early T-cell activation antigen p60, Leukocyte surface antigen Leu-23. CD69 contains one C-type lectin domain. CD69 / CLEC2C is expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets. CD69 is induced by antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes and by interaction of IL-2 with the p75 IL-2R on the surface of NK cells. CD69 / CLEC2C involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.

Clinical and Translational Updates

公開薬物情報

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Decitabine/Cedazuridine ASTX-727-LD; ASTX-727-10; E-7727/decitabine; Decitabine/E7727; ASTX-727 Approved Astex Pharmaceuticals Inc, National Cancer Institute INAQOVI, Inaqovi, Inqovi United States Myelodysplastic Syndromes Otsuka Pharmaceutical Co Ltd 2020-07-07 Leukemia, Myelogenous, Chronic; Leukemia; Solid tumours; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Neoplasms; Triple Negative Breast Neoplasms; Mesothelioma; Breast Neoplasms; Leukemia, Myeloid, Acute; Glioma; Nervous System Neoplasms; Neurilemmoma Details
Mecobalamin E-0302 Approved Myelogen, Naso B12, NASOCOBAL, Methycobal, 弥尔神, 悦敏兴, RHINOCOBAL, 奇信, 曲力, 弥可保 Peripheral Nervous System Diseases; Autistic Disorder; Neuritis; Neuralgia; Vitamin B 12 Deficiency; Amyotrophic Lateral Sclerosis; Fibromyalgia Details
Azacitidine NSC-102816; 5-aza-CR; CC-486; NS-17; U-18496; NEX-18; NEX-18a Approved Celgene Corp 维达莎, Vidaza, Onureg United States Myelodysplastic Syndromes Bristol-Myers Squibb Company 2004-05-19 Leukemia, Myeloid, Acute; Immune System Diseases; Prostatic Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Breast Neoplasms; Osteosarcoma; Sarcoma; Brain Neoplasms; Tuberculosis, Pulmonary; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Hepatic Insufficiency; Multiple Myeloma; Lymphoma; Leukemia, Myelomonocytic, Juvenile; Lymphoma, Non-Hodgkin; Thyroid Neoplasms; Lung Neoplasms; Myelodysplastic-Myeloproliferative Diseases; Melanoma; Leukemia, Lymphocytic, Chronic, B-Cell; Carcinoma, Non-Small-Cell Lung; Leukemia, Large Granular Lymphocytic; Myeloproliferative Disorders; Leukemia, Myeloid; Leukemia; Ependymoma; Leukemia, Myelogenous, Chronic; Solid tumours; Hematologic Neoplasms; Intestinal Neoplasms; Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Lymphoma, T-Cell, Peripheral; Myelodysplastic Syndromes; Nasopharyngeal Neoplasms; Leukemia, Myelomonocytic, Chronic; Neoplasms; Small Cell Lung Carcinoma; Hodgkin Disease; Glioblastoma; Details
Triclabendazole EGA-230B; CGA-89317; NVP-EGA230 Approved Novartis Pharma Ag Egaten, Fasinex, Triclathera Iran Fascioliasis Novartis Pharma Ag 1989-01-01 Fascioliasis Details
Decitabine 5-aza-CdR; NSC-127716; AzadC; E-7373; DAC Approved Eisai Co Ltd Dacogen, 达珂 Mainland China Myelodysplastic Syndromes Mgi Pharma Inc 2006-05-02 Lymphoma, Non-Hodgkin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vulvar Neoplasms; Lymphoma, Mantle-Cell; Neuroblastoma; Breast Neoplasms; Lymphoma, Follicular; Colorectal Neoplasms; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Primary Myelofibrosis; Leukemia, Myeloid, Acute; Burkitt Lymphoma; Lung Neoplasms; Multiple Myeloma; Lymphoma; Thyroid Neoplasms; Anemia, Sickle Cell; Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell; Myelodysplastic-Myeloproliferative Diseases; Neoplasm Metastasis; Thyroid Cancer, Papillary; Melanoma; Precancerous Conditions; Breast Neoplasms, Male; Leukemia, Myelomonocytic, Chronic; Leukemia, Promyelocytic, Acute; Liver Neoplasms; Leukemia, Myelogenous, Chronic; Leukemia; Purpura, Thrombocytopenic, Idiopathic; Lymphoma, B-Cell, Marginal Zone; Solid tumours; Thalassemia; Neutropenia; Esophageal Neoplasms; Myelodysplastic Syndromes; Leukemia, Myeloid, Accelerated Phase; Small Cell Lung Carcinoma; Myeloproliferative Disorders; Lymphoma, Large B-Cel Details
Decitabine/Cedazuridine ASTX-727-LD; ASTX-727-10; E-7727/decitabine; Decitabine/E7727; ASTX-727 Approved Astex Pharmaceuticals Inc, National Cancer Institute INAQOVI, Inaqovi, Inqovi United States Myelodysplastic Syndromes Otsuka Pharmaceutical Co Ltd 2020-07-07 Leukemia, Myelogenous, Chronic; Leukemia; Solid tumours; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Neoplasms; Triple Negative Breast Neoplasms; Mesothelioma; Breast Neoplasms; Leukemia, Myeloid, Acute; Glioma; Nervous System Neoplasms; Neurilemmoma Details
Mecobalamin E-0302 Approved Myelogen, Naso B12, NASOCOBAL, Methycobal, 弥尔神, 悦敏兴, RHINOCOBAL, 奇信, 曲力, 弥可保 Peripheral Nervous System Diseases; Autistic Disorder; Neuritis; Neuralgia; Vitamin B 12 Deficiency; Amyotrophic Lateral Sclerosis; Fibromyalgia Details
Azacitidine NSC-102816; 5-aza-CR; CC-486; NS-17; U-18496; NEX-18; NEX-18a Approved Celgene Corp 维达莎, Vidaza, Onureg United States Myelodysplastic Syndromes Bristol-Myers Squibb Company 2004-05-19 Leukemia, Myeloid, Acute; Immune System Diseases; Prostatic Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Breast Neoplasms; Osteosarcoma; Sarcoma; Brain Neoplasms; Tuberculosis, Pulmonary; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Hepatic Insufficiency; Multiple Myeloma; Lymphoma; Leukemia, Myelomonocytic, Juvenile; Lymphoma, Non-Hodgkin; Thyroid Neoplasms; Lung Neoplasms; Myelodysplastic-Myeloproliferative Diseases; Melanoma; Leukemia, Lymphocytic, Chronic, B-Cell; Carcinoma, Non-Small-Cell Lung; Leukemia, Large Granular Lymphocytic; Myeloproliferative Disorders; Leukemia, Myeloid; Leukemia; Ependymoma; Leukemia, Myelogenous, Chronic; Solid tumours; Hematologic Neoplasms; Intestinal Neoplasms; Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Lymphoma, T-Cell, Peripheral; Myelodysplastic Syndromes; Nasopharyngeal Neoplasms; Leukemia, Myelomonocytic, Chronic; Neoplasms; Small Cell Lung Carcinoma; Hodgkin Disease; Glioblastoma; Details
Triclabendazole EGA-230B; CGA-89317; NVP-EGA230 Approved Novartis Pharma Ag Egaten, Fasinex, Triclathera Iran Fascioliasis Novartis Pharma Ag 1989-01-01 Fascioliasis Details
Decitabine 5-aza-CdR; NSC-127716; AzadC; E-7373; DAC Approved Eisai Co Ltd Dacogen, 达珂 Mainland China Myelodysplastic Syndromes Mgi Pharma Inc 2006-05-02 Lymphoma, Non-Hodgkin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vulvar Neoplasms; Lymphoma, Mantle-Cell; Neuroblastoma; Breast Neoplasms; Lymphoma, Follicular; Colorectal Neoplasms; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Primary Myelofibrosis; Leukemia, Myeloid, Acute; Burkitt Lymphoma; Lung Neoplasms; Multiple Myeloma; Lymphoma; Thyroid Neoplasms; Anemia, Sickle Cell; Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell; Myelodysplastic-Myeloproliferative Diseases; Neoplasm Metastasis; Thyroid Cancer, Papillary; Melanoma; Precancerous Conditions; Breast Neoplasms, Male; Leukemia, Myelomonocytic, Chronic; Leukemia, Promyelocytic, Acute; Liver Neoplasms; Leukemia, Myelogenous, Chronic; Leukemia; Purpura, Thrombocytopenic, Idiopathic; Lymphoma, B-Cell, Marginal Zone; Solid tumours; Thalassemia; Neutropenia; Esophageal Neoplasms; Myelodysplastic Syndromes; Leukemia, Myeloid, Accelerated Phase; Small Cell Lung Carcinoma; Myeloproliferative Disorders; Lymphoma, Large B-Cel Details

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Curcumin VOLT-03; VOLT-3; NSC-32982 Phase 3 Clinical University Of Pennsylvania Neuralgia; Asthma; Cigarette Smoking; Uterine Cervical Dysplasia; Cervical Intraepithelial Neoplasia; Primary Myelofibrosis; Periapical Diseases; Dentist-Patient Relations; Colorectal Neoplasms; Lymphoma, T-Cell, Cutaneous; Cognitive Dysfunction; Pancytopenia; Breast Neoplasms; Prostatic Neoplasms; Oral Submucous Fibrosis; Tobacco Use Disorder; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Urinary Incontinence, Urge; Adenocarcinoma, Mucinous; Lung Neoplasms; Lichen Planus, Oral; Renal Insufficiency, Chronic; Osteoarthritis; Carcinoma, Non-Small-Cell Lung; Crohn Disease; Adenocarcinoma; Aortic Aneurysm, Abdominal; Thrombocythemia, Essential; Uterine Cervical Neoplasms; Stomatitis; Neoplasm Metastasis; Macular Degeneration; Condylomata Acuminata; Rectal Neoplasms; Arthritis, Rheumatoid; Pain; Spasm; Polycythemia Vera; Radiodermatitis; Digestive System Diseases; Diabetes Mellitus, Type 2; Metabolic Dysfunction-Associated Steatotic Liver Disease; Proteinuria; Gastritis, Atrophic; Depression; Optic Atrophy, Here Details
Azacitidine/Cedazuridine ASTX-030 Phase 3 Clinical Otsuka Pharmaceutical Co Ltd Leukemia, Myelogenous, Chronic; Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
Guadecitabine Sodium SGI-110; S-110; 0RB89YH367 (UNII code) Phase 3 Clinical Otsuka Holdings Co Ltd Klatskin Tumor; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Melanoma; Paraganglioma; Carcinoma, Hepatocellular; Gallbladder Neoplasms; Lung Neoplasms; Leukemia, Myeloid, Acute; Fallopian Tube Neoplasms; Colorectal Neoplasms; Peritoneal Neoplasms; Gastrointestinal Stromal Tumors; Cholangiocarcinoma; Chondrosarcoma; Prostatic Neoplasms, Castration-Resistant; Myeloproliferative Disorders; Small Cell Lung Carcinoma; Pancreatic Neoplasms; Carcinoma, Transitional Cell; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Stomach Neoplasms; Pheochromocytoma; Carcinoma, Renal Cell; Kidney Neoplasms; Ovarian Neoplasms Details
EF-009 EF-009 Phase 2 Clinical Everfront Biotech Co Ltd Pancreatic Neoplasms Details
Fluorocyclopentenylcytosine FCPEC; RX-3117; TV-1360; PCS-3117; RX 3117 Phase 2 Clinical Rexahn Pharmaceuticals Inc Solid tumours; Pancreatic Neoplasms; Urinary Bladder Neoplasms Details
FdCyd NSC-48006; Ro-5-1090 Phase 2 Clinical City Of Hope National Medical Center, National Cancer Institute Head and Neck Neoplasms; Esophageal Neoplasms; Neoplasms; Small Cell Lung Carcinoma; Myelodysplastic Syndromes; Urinary Bladder Neoplasms; Mesothelioma; Breast Neoplasms; Lung Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Non-Small-Cell Lung Details
Azacitidine (Boryung Pharmaceutical) Phase 2 Clinical Boryung Pharmaceutical Co Ltd Neoplasms Details
Decitabine/Tetrahydrouridine (EpiDestiny/Novo Nordisk) EPI-01; EPI01; NN 7533 Phase 2 Clinical Epicdestiny Anemia, Sickle Cell Details
NTX-301 NTX-303 Phase 1 Clinical Southern Research Institute, Pinotbio Inc Solid tumours; Ovarian Neoplasms; Neoplasms; Carcinoma, Transitional Cell; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Glioma; Leukemia, Myeloid, Acute Details
Curcumin VOLT-03; VOLT-3; NSC-32982 Phase 3 Clinical University Of Pennsylvania Neuralgia; Asthma; Cigarette Smoking; Uterine Cervical Dysplasia; Cervical Intraepithelial Neoplasia; Primary Myelofibrosis; Periapical Diseases; Dentist-Patient Relations; Colorectal Neoplasms; Lymphoma, T-Cell, Cutaneous; Cognitive Dysfunction; Pancytopenia; Breast Neoplasms; Prostatic Neoplasms; Oral Submucous Fibrosis; Tobacco Use Disorder; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Urinary Incontinence, Urge; Adenocarcinoma, Mucinous; Lung Neoplasms; Lichen Planus, Oral; Renal Insufficiency, Chronic; Osteoarthritis; Carcinoma, Non-Small-Cell Lung; Crohn Disease; Adenocarcinoma; Aortic Aneurysm, Abdominal; Thrombocythemia, Essential; Uterine Cervical Neoplasms; Stomatitis; Neoplasm Metastasis; Macular Degeneration; Condylomata Acuminata; Rectal Neoplasms; Arthritis, Rheumatoid; Pain; Spasm; Polycythemia Vera; Radiodermatitis; Digestive System Diseases; Diabetes Mellitus, Type 2; Metabolic Dysfunction-Associated Steatotic Liver Disease; Proteinuria; Gastritis, Atrophic; Depression; Optic Atrophy, Here Details
Azacitidine/Cedazuridine ASTX-030 Phase 3 Clinical Otsuka Pharmaceutical Co Ltd Leukemia, Myelogenous, Chronic; Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
Guadecitabine Sodium SGI-110; S-110; 0RB89YH367 (UNII code) Phase 3 Clinical Otsuka Holdings Co Ltd Klatskin Tumor; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Melanoma; Paraganglioma; Carcinoma, Hepatocellular; Gallbladder Neoplasms; Lung Neoplasms; Leukemia, Myeloid, Acute; Fallopian Tube Neoplasms; Colorectal Neoplasms; Peritoneal Neoplasms; Gastrointestinal Stromal Tumors; Cholangiocarcinoma; Chondrosarcoma; Prostatic Neoplasms, Castration-Resistant; Myeloproliferative Disorders; Small Cell Lung Carcinoma; Pancreatic Neoplasms; Carcinoma, Transitional Cell; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Stomach Neoplasms; Pheochromocytoma; Carcinoma, Renal Cell; Kidney Neoplasms; Ovarian Neoplasms Details
EF-009 EF-009 Phase 2 Clinical Everfront Biotech Co Ltd Pancreatic Neoplasms Details
Fluorocyclopentenylcytosine FCPEC; RX-3117; TV-1360; PCS-3117; RX 3117 Phase 2 Clinical Rexahn Pharmaceuticals Inc Solid tumours; Pancreatic Neoplasms; Urinary Bladder Neoplasms Details
FdCyd NSC-48006; Ro-5-1090 Phase 2 Clinical City Of Hope National Medical Center, National Cancer Institute Head and Neck Neoplasms; Esophageal Neoplasms; Neoplasms; Small Cell Lung Carcinoma; Myelodysplastic Syndromes; Urinary Bladder Neoplasms; Mesothelioma; Breast Neoplasms; Lung Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Non-Small-Cell Lung Details
Azacitidine (Boryung Pharmaceutical) Phase 2 Clinical Boryung Pharmaceutical Co Ltd Neoplasms Details
Decitabine/Tetrahydrouridine (EpiDestiny/Novo Nordisk) EPI-01; EPI01; NN 7533 Phase 2 Clinical Epicdestiny Anemia, Sickle Cell Details
NTX-301 NTX-303 Phase 1 Clinical Southern Research Institute, Pinotbio Inc Solid tumours; Ovarian Neoplasms; Neoplasms; Carcinoma, Transitional Cell; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Glioma; Leukemia, Myeloid, Acute Details

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