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CD27 Ligand

概要

Name:CD70 antigen
Target Synonym:CD70 antigen,Surface Antigen CD70,LPFS3,CD27L,Tumor necrosis factor ligand superfamily member 7,CD27LG,CD27-L,CD70,CD70 Molecule,TNFSF7,Tumor Necrosis Factor (Ligand) Superfamily, Member 7,Tumor Necrosis Factor Ligand 8A,Ki-24 Antigen,TNLG8A,CD27 Ligand
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:17
Lastest Research Phase:Phase 2 Clinical

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
CD70 VHH - 01 Lead Hematological Malignancy Non-hodgkin lymphoma

製品リスト製品比較と製品注文

製造番号 種類 製品説明 構造 純度 特徴
CDL-HA245 Human Alexa Fluor™ 555-Labeled Human CD27 Ligand / CD70 Protein, His TagStar Staining
CDL-HF249 Human FITC-Labeled Human CD27 Ligand / CD70 Protein, His TagStar Staining
CDL-HA247 Human Alexa Fluor™ 488-Labeled Human CD27 Ligand / CD70 Protein, His TagStar Staining
CDL-HA246 Human Alexa Fluor™ 647-Labeled Human CD27 Ligand / CD70 Protein, His TagStar Staining
CDL-HA248 Human APC-Labeled Human CD27 Ligand / CD70 Protein, His TagStar Staining
CDL-HP246 Human PE-Labeled Human CD27 Ligand / CD70 Protein, His TagStar Staining
CDL-H5255 Human Human CD27 Ligand / CD70 Protein, Llama IgG2b Fc Tag, low endotoxin
CDL-H5255-sds
CDD-HF2D4 Human FITC-Labeled Human CD27 Ligand / CD70 Protein, His,Flag Tag, active trimer (MALS verified)
CDD-HF2D4-sds
CDL-H82D7 Human Biotinylated Human CD27 Ligand / CD70 Protein, His,Avitag™,Flag Tag, active trimer (MALS verified)
CDL-H82D7-sds
CDL-H52Da Human Human CD27 Ligand / CD70 Protein, His,Flag Tag, active trimer (MALS verified)
CDL-H52Da-sds
CDL-H5266 Human Human CD27 Ligand / CD70 Protein, Fc Tag, active trimer (MALS verified)
CDL-H5266-sds
CDL-M82Qb Mouse Biotinylated Mouse CD27 Ligand / CD70 Protein, His,Avitag™
CDL-M82Qb-structure
CDL-M82Qb-sds
CDL-M5245 Mouse Mouse CD27 Ligand / CD70 Protein, His Tag, active trimer (MALS verified)
CDL-M5245-structure
CDL-M5245-sds
CDL-H525a Human Human CD27 Ligand / CD70 Protein, Mouse IgG2a Fc Tag, low endotoxin
CDL-H525a-structure
CDL-H525a-sds
CDL-M5251 Mouse Mouse CD27 Ligand / CD70 Protein, Mouse IgG2a Fc Tag, low endotoxin
CDL-M5251-structure
CDL-M5251-sds
ACRO Quality

生物活性データの一部

CDL-HA245-Cell-based assay
 CD27 Ligand CAR_T

5e5 of 293 CAR cells transfected with anti-CD27 Ligand-scFv were stained with 100 μL of 3 μg/mL of Alexa Fluor 555-Labeled Human CD27 Ligand Protein, His Tag (Cat. No. CDL-HA245) and negative control protein respectively (Fig. C and B), and non-transfected 293 cells were used as a control (Fig. A), Alexa 555 signal was used to evaluate the binding activity (QC tested).

CDD-HF2D4-ELISA
 CD27 Ligand ELISA

Immobilized Anti-CD27 Ligand Antibody, Human IgG1 at 1 μg/mL (100 μL/well) can bind FITC-Labeled Human CD27 Ligand, His,Flag Tag (Cat. No. CDD-HF2D4) with a linear range of 0.039-0.156 μg/mL (QC tested).

CDD-HF2D4-MALS-HPLC
CD27 Ligand MALS images

The purity of FITC-Labeled Human CD27 Ligand, His,Flag Tag (Cat. No. CDD-HF2D4) is more than 85% and the molecular weight of this protein is around 55-74 kDa verified by SEC-MALS.

Synonym Name

CD70,CD27LG,TNFSF7,TNFSF7G,CD27L

Background

Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.

Clinical and Translational Updates

相関分子

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Cusatuzumab ARGX-110; JNJ-4550 Phase 2 Clinical Argenx Se Myelodysplastic Syndromes; Neoplasms; Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Acute Details
ARX-305 ARX-305; NCB-002 Phase 1 Clinical Ambrx Inc, Zhejiang Xinma Biomedicine Co Ltd Neoplasms Details
CD70 Targeted CAR-T Cells Therapy(UTC Therapeutics) Phase 2 Clinical UTC Therapeutics Inc Solid tumours; Urologic Neoplasms; Lymphoma Details
BR-108 BR-108 Phase 1 Clinical BioRay Pharmaceutical Co Ltd Leukemia; Hematologic Neoplasms Details
C-4-29 Phase 1 Clinical Chongqing Precision Biotechnology Co Ltd Carcinoma, Renal Cell; Multiple Myeloma Details
SEA-CD70 SEA-CD70 Phase 1 Clinical Seattle Genetics Inc Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
Cord Blood-derived CAR NK Cells Targeting CD19/CD70(Tongji University) Tongji University Details
PRO-1160 PRO-1160 Phase 2 Clinical ProfoundBio (Suzhou) Co Ltd Solid tumours; Carcinoma, Renal Cell; Nasopharyngeal Carcinoma; Lymphoma; Lymphoma, Non-Hodgkin Details
Anti-CD19/CD70 NK cell therapy (Zhejiang University) Phase 1 Clinical Zhejiang University Lymphoma, Non-Hodgkin Details
CTX-130 CTX-130 Phase 1 Clinical Crispr Therapeutics Ag Carcinoma, Renal Cell; Lymphoma, T-Cell Details
CD70 CAR-T cell therapy (Chongqing Precision Biotech) Phase 1 Clinical Chongqing Precision Biotechnology Co Ltd Ovarian Neoplasms; Solid tumours; Carcinoma, Renal Cell; Neoplasms; Neoplasm Metastasis; Uterine Cervical Neoplasms Details
ALLO-316 ALLO-316 Phase 1 Clinical Allogene Therapeutics Inc Carcinoma, Renal Cell Details
GD2/CD70 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) bi-4SCAR GD2/CD70 Phase 2 Clinical Shenzhen Geno-Immune Medical Institute Neoplasms Details
IMM-40H IMM-40H; IMM40H Phase 1 Clinical ImmuneOnco Biopharmaceuticals (Shanghai) Co Ltd Hematologic Neoplasms; Solid tumours; Neoplasms Details
MP0533 MP0533 Phase 2 Clinical Molecular Partners Ag Leukemia, Myeloid, Acute Details
CD19/70 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) Phase 2 Clinical Shenzhen Geno-Immune Medical Institute Lymphoma, B-Cell; Leukemia, B-Cell Details
CD70-CART(Hrain) HR010; HR-010 Phase 1 Clinical Hrain Biotechnology Co Ltd Carcinoma, Renal Cell Details
PSMA/CD70 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) bi-4SCAR PSMA/CD70 Phase 2 Clinical Shenzhen Geno-Immune Medical Institute Neoplasms Details

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