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Human MAdCAM-1, His Tag (Cat. No. MAM-H52H4) immobilized on CM5 Chip can bind Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT7-H52W4) with an affinity constant of 0.227 μM as determined in a SPR assay (Biacore 8K) (QC tested).
| Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
|---|---|---|---|---|---|---|---|---|---|---|
| Vedolizumab | MLN-0002; LPD-02; MLN-002; MLN-02; LDP-02 | Approved | Millennium Pharmaceuticals Inc | 安吉优, Entyvio | United States | Colitis, Ulcerative; Crohn Disease | Takeda Pharmaceuticals U.S.A. Inc | 2014-05-20 | Colitis; Melanoma; Carcinoma, Non-Small-Cell Lung; Crohn Disease; Urogenital Neoplasms; Colitis, Ulcerative; Pediatric ulcerative colitis; Celiac Disease; Cholangitis, Sclerosing; Solid tumours; Neoplasms; Pouchitis; Pediatric Crohn's disease; Inflammatory Bowel Diseases; Acquired Immunodeficiency Syndrome; Hematopoietic stem cell transplantation (HSCT); HIV Infections | Details |
| Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
|---|---|---|---|---|---|
| Ontamalimab | SHP-647; PF-00547659; PF-547659 | Phase 3 Clinical | Pfizer Inc | Ileitis; Colitis, Ulcerative; Crohn Disease | Details |
| Vedolizumab biosimilar (Polpharma Biologics) | PB-016 | Phase 3 Clinical | Polpharma Biologics Sa | Pouchitis; Colitis, Ulcerative; Crohn Disease | Details |
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