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Sortilin

概要

Name:Sortilin
Target Synonym:100 kDa NT receptor,NT3,Glycoprotein 95,LDLCQ6,NTR3,Gp95,Sortilin 1,Neurotensin receptor 3
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 3 Clinical

製品リスト製品比較と製品注文

ACRO Quality

生物活性データの一部

SON-H82E9-SPR
 Sortilin SPR

Biotinylated Human Sortilin Protein, His,Avitag (Cat. No. SON-H82E9) captured on Biotin CAP-Series S Sensor Chip can bind Human Progranulin Protein, His Tag (Cat. No. PGN-H52H3) with an affinity constant of 0.355 μM as determined in a SPR assay (Biacore 8K) (QC tested).

SON-H82E9-MALS-HPLC
Sortilin MALS images

The purity of Biotinylated Human Sortilin Protein, His,Avitag (Cat. No. SON-H82E9) is more than 85% and the molecular weight of this protein is around 80-107 kDa verified by SEC-MALS.

Synonym Name

Sortilin,SORT1,100 kDa NT receptor,Glycoprotein 95,Gp95,Gp95LDLCQ6,Neurotensin receptor 3,NT3NTR3,Ntr3,sortilin 1,

Background

The Sortilin is a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Latozinemab AL-001; GSK-4527223 Phase 3 Clinical Alector Inc, Glaxosmithkline Plc Bipolar Disorder; Neurodegenerative Diseases; Frontotemporal Dementia; Amyotrophic Lateral Sclerosis Details
VES-001 VES-001; VES001 Phase 1 Clinical Vesper Bio APS Frontotemporal Dementia Details

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