BMP-7

Bone Morphogenetic Protein 7 (BMP7) is a member of growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. BMP-7 Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. BMP-7 can signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors.