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SHP-2

概要

Name:Src homology phosphotyrosyl phosphatase 2
Target Synonym:Protein Tyrosine Phosphatase Non-Receptor Type 11,SHP-2,PTP2C,Protein-tyrosine phosphatase 2C,PTP-2C,PTP-1D,SH-PTP3,PTPN11,Protein-Tyrosine Phosphatase 1D,SH-PTP2,EC:3.1.3.48,Noonan Syndrome 1,EC 3.1.3.48,METCDS,SHPTP2,BPTP3,JMML,SHP2,CFC,NS1,Protein Tyrosine Phosphatase, Non-Receptor Type 11,Tyrosine-Protein Phosphatase Non-Receptor Type 11
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:16
Lastest Research Phase:Phase 2 Clinical

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SH2-H5248 Human Human SHP-2 Protein, His Tag
SH2-H5248-structure
SH2-H5248-sds
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臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
ERAS-601 ERAS-601 Phase 1 Clinical Erasca Inc Solid tumours; Leukemia, Myeloid, Acute Details
GH-21 GH-21; HBI-2376 Phase 2 Clinical Suzhou GenHouse pharmaceutical Co Ltd Solid tumours; Head and Neck Neoplasms; Pancreatic Neoplasms; Colonic Neoplasms; Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
BPI-442096 Phase 1 Clinical Betta Pharmaceuticals Co Ltd Solid tumours; Pancreatic Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
JAB-3068 JAB-3068 Phase 2 Clinical Jacobio Pharmaceuticals Co Ltd, Abbvie Inc Solid tumours; Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Carcinoma, Non-Small-Cell Lung Details
JAB-3312 JAB-3312 Phase 2 Clinical Jacobio Pharmaceuticals Co Ltd, Abbvie Inc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Esophageal Squamous Cell Carcinoma; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung Details
RLY-1971 RG-6433; RLY-1971; GDC-1971; RO-7517834 Phase 1 Clinical Relay Therapeutics Inc Solid tumours; Colorectal Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
SH-3809 SH3809 Phase 1 Clinical Nanjing Sanhome Pharmaceutical Co Ltd Solid tumours Details
HMPL-415S1 HMPL-415S1 Phase 1 Clinical Hutchison Medipharma Ltd Solid tumours Details
BR-790 BR-790 Phase 2 Clinical Jiangxi Qingfeng Pharmaceutical Industry Co Ltd Solid tumours; Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Vociprotafib RMC-4630; SAR-442720 Phase 2 Clinical Sanofi, Revolution Medicines Inc Solid tumours; Neoplasms; Pancreatic Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details
ICP-189 ICP-189 Phase 1 Clinical InnoCare Pharma Ltd Solid tumours; Carcinoma, Non-Small-Cell Lung Details
PF-07284892 ARRY-558; PF-07284892 Phase 1 Clinical Pfizer Inc Solid tumours Details
SHP2 inhibitor (Navire Pharma) IACS-15509; BBP-398; IACS-13909; BMS-986466 Phase 2 Clinical Bridgebio Pharma Inc, The University Of Texas MD Anderson Cancer Center Solid tumours; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details
ET-0038 ET-0038 Phase 1 Clinical Shanghai Yituo Pharmaceutical Technology Co Ltd Solid tumours Details
TNO-155 TNO-155 Phase 2 Clinical Novartis Pharma Ag Solid tumours; Squamous Cell Carcinoma of Head and Neck; Neoplasms; Kidney Diseases; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Hepatic Insufficiency; Lung Neoplasms; Esophageal Squamous Cell Carcinoma; Carcinoma, Non-Small-Cell Lung; Melanoma; Neoplasm Metastasis Details
RG-001 RG001; RG-001 Phase 1 Clinical Shanghai Lingji Biological Technology Co Ltd Neoplasms Details

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