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Your Position: ホーム > Akt1

Akt1

概要

Name:Serine/threonine-protein kinase AKT
Target Synonym:EC 2.7.11,EC 2.7.11.1,PKB-ALPHA,RAC-ALPHA,AKT1m,PRKBA,CWS6,AKT,PKB alpha,RAC-alpha serine/threonine-protein kinase,AKT1,AKT Serine/Threonine Kinase 1,Protein Kinase B Alpha,PKB,Serine-Threonine Protein Kinase,Rac Protein Kinase Alpha,Proto-oncogene c-Akt,Protein kinase B,RAC,RAC-PK-alpha,V-Akt Murine Thymoma Viral Oncogene-Like Protein 1,V-Akt Murine Thymoma Viral Oncogene Homolog 1,EC:2.7.11.1
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:18
Lastest Research Phase:Approved

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AK1-H5283 Human Human Akt1 Protein, His,Strep II Tag
AK1-H5283-structure
AK1-H5283-sds
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Synonym Name

AKT1,PKB,RAC,RAC-PK-alpha,PKB alpha

Background

RAC-alpha serine/threonine-protein kinase (AKT1) is also known PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt and RAC-PK-alpha, which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and RAC subfamily and is expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase).

Clinical and Translational Updates

公開薬物情報

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Capivasertib AZD-5363 Approved Astex Pharmaceuticals Inc, Cancer Research Technology, The Institute Of Cancer Research, London TRUQAP, Truqap United States Breast Neoplasms; HR-positive breast cancer Astrazeneca Pharmaceuticals Lp, Astrazeneca Ab 2023-11-16 Glioma; Prostatic Neoplasms; Breast Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Peritoneal Neoplasms; Metastatic breast cancer; Lymphoma, Non-Hodgkin; Lymphoma; Endometrial Neoplasms; Urinary Bladder Neoplasms; Uterine Neoplasms; Esophageal adenocarcinoma; HR-positive breast cancer; Fallopian Tube Neoplasms; Thyroid Neoplasms; Lung Neoplasms; Melanoma; Uterine Cervical Neoplasms; Triple Negative Breast Neoplasms; Ovarian Neoplasms; Hematologic Neoplasms; Liver Neoplasms; Head and Neck Neoplasms; Carcinoma, Renal Cell; Stomach Neoplasms; Rectal Neoplasms; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Solid tumours; Neoplasms; Carcinoma, Ovarian Epithelial; Pancreatic Neoplasms; Colonic Neoplasms; Carcinoma, Transitional Cell; Skin Neoplasms; Prostatic Neoplasms, Castration-Resistant; Multiple Myeloma Details

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Hu-7691 Hu-7691 Phase 1 Clinical Zhejiang University Solid tumours; Neoplasms Details
CMX-2043 LIP-EA; CMX-2043; R-LIP-EA-OH Phase 1 Clinical Ischemix Llc Brain Injuries, Traumatic; Angina, Unstable; Coronary Artery Disease Details
TAS-117 TAS-117 Phase 2 Clinical Otsuka Pharmaceutical Co Ltd, Taiho Pharmaceutical Co Ltd Solid tumours Details
Miransertib MK-7075; ARQ-092 Phase 2 Clinical Arqule Inc Proteus Infections; Solid tumours; Ovarian Neoplasms; Neoplasms; PIK3CA-Related Overgrowth Spectrum; Lymphoma; Endometrial Neoplasms; Proteus Syndrome Details
Selumetinib sulfate/MK-2206 Phase 2 Clinical Astrazeneca Plc, Merck & Co Inc Rectal Neoplasms; Triple Negative Breast Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
NTQ-1062 NTQ-1062; NTQ1062 Phase 2 Clinical Nanjing Zhengda Tianqing Pharmaceutical Co Ltd Solid tumours; Breast Neoplasms; HR-positive breast cancer Details
Oxysterols (Intsel Chimos) Clinical Centre National De La Recherche Scientifique (Cnrs) Glioma Details
RX-0301 HC0301; RX-0201-N; RX-0301; WGI-0301; RX-0201改良型; RX-0201 nanoliposomal; RX-0201 Nano Phase 1 Clinical Rexahn Pharmaceuticals Inc Liver Neoplasms; Solid tumours Details
Honokiol HU-002; JRF-101 Phase 1 Clinical Anacor Pharmaceuticals Inc Non-alcoholic Fatty Liver Disease; Gingival Diseases; Carcinoma, Non-Small-Cell Lung Details
Triciribine Phosphate NSC-154020; PTX-002; API-2; TCN-P; VQD-002-ORAL; VQD-002; NSC-280594; PTX-200 Phase 2 Clinical National Cancer Institute Ovarian Neoplasms; Hematologic Neoplasms; Leukemia; Neoplasms; Breast Neoplasms Details
Uprosertib/Trametinib Dimethyl Sulfoxide Phase 2 Clinical Novartis Pharma Ag Leukemia, Myeloid, Acute; Endometrial Neoplasms; Uterine Cervical Neoplasms Details
Uprosertib GSK-795; GSK-2141795; GSK-2141795C; UPB-795 Phase 2 Clinical Glaxosmithkline Plc, Novartis Pharma Ag, National Cancer Institute Solid tumours; Hematologic Neoplasms; Triple Negative Breast Neoplasms; Neoplasms; Multiple Myeloma; Breast Neoplasms; Leukemia, Myeloid, Acute; Lymphoma; Uterine Neoplasms; Endometrial Neoplasms; Uterine Cervical Neoplasms; Melanoma; Adenocarcinoma Details
HZB-0071 HZB-0071 Phase 1 Clinical Wuxi Apptec Co Ltd, Heilongjiang Zbd Pharmaceutical Co Ltd Neoplasms Details
Iopofosine I-131 CLR-131; NM404; (131)I-CLR1404; 131I-NM-404; HOT; CLR1404 I-131; I-131-CLR1404; (131)I-NM 404 Phase 2 Clinical University Of Michigan Neuroblastoma; Central Nervous System Lymphoma; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma; Glioma; Waldenstrom Macroglobulinemia; Diffuse Intrinsic Pontine Glioma; Sarcoma, Ewing; Brain Neoplasms; Lymphoma, B-Cell, Marginal Zone; Osteosarcoma; Lymphoma, Mantle-Cell; Multiple Myeloma; Neoplasms; Lymphoma, Large B-Cell, Diffuse; Rhabdomyosarcoma; Solid tumours; Head and Neck Neoplasms Details
Ipatasertib Dihydrochloride RG-7440; GCD-0068; GDC-0068; RO-5532961 Phase 3 Clinical Array Biopharma, F. Hoffmann-La Roche Ltd Paranasal Sinus Neoplasms; Hepatic Insufficiency; Urogenital Neoplasms; Neoplasms, Unknown Primary; Endometrial Neoplasms; Carcinoma, Squamous Cell; Lip Neoplasms; Laryngeal Neoplasms; Mouth Neoplasms; Peritoneal Neoplasms; Lymphoma, Non-Hodgkin; Fallopian Tube Neoplasms; Paranasal Sinus Diseases; Uterine Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Endometrioid; Adenocarcinoma; Glioblastoma; Solid tumours; Neoplasm, Residual; Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Cystadenocarcinoma, Serous; Triple Negative Breast Neoplasms; Neoplasms; Ovarian Neoplasms; Hypopharyngeal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Breast Neoplasms; Prostatic Neoplasms; Cholangiocarcinoma; Genital Neoplasms, Female; Oropharyngeal Neoplasms Details
Afuresertib ASB-183; GSK-2110183; GSK-2110183B; GSK-2110183C; GSK-21110183; LAE-002 Phase 3 Clinical Glaxosmithkline Plc, Novartis Pharma Ag Breast Neoplasms; Adenocarcinoma; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell; Endometrial Neoplasms; Metastatic breast cancer; Fallopian Tube Neoplasms; Peritoneal Neoplasms; Hematologic Neoplasms; Histiocytosis, Langerhans-Cell; Multiple Myeloma; Triple Negative Breast Neoplasms; Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Solid tumours; Ovarian Neoplasms Details
MK-2206 MK2206; MK-2206; BIND-2206; NSC-749607 Phase 2 Clinical Merck Sharp & Dohme Corp Glioma; Waldenstrom Macroglobulinemia; Intraocular Lymphoma; Adenocarcinoma, Mucinous; Leukemia, Myelomonocytic, Juvenile; Burkitt Lymphoma; Lymphoma, Non-Hodgkin; Fallopian Tube Neoplasms; Gallbladder Neoplasms; Endometrial Neoplasms; Lung Neoplasms; Neoplasms, Gonadal Tissue; Colorectal Neoplasms; Adenocarcinoma, Bronchiolo-Alveolar; Lymphoproliferative Disorders; Sezary Syndrome; Leukemia, Myeloid, Chronic-Phase; Peritoneal Neoplasms; Bile Duct Neoplasms; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Cholangiocarcinoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Carcinoma, Non-Small-Cell Lung; Central Nervous System Lymphoma; Carcinoma, Hepatocellular; Adenocarcinoma; Melanoma; Leukemia, Prolymphocytic; Leukemia, Large Granular Lymphocytic; Leukemia, T-Cell; Mycosis Fungoides; Breast Neoplasms, Male; Leukemia, Lymphocytic, Chronic, B-Cell; Carcinoma, Adenosquamous; Thymoma; Carcinoma, Pancreatic Ductal; Leukemia, Monocytic, Acute; Lymphoma, T-Cell; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Details
TIC-10 ONC201 - Oncoceutics; ONC201/TIC10; NSC-350625; TIC-10; ONC-201 Phase 3 Clinical Oncoceutics Inc Colorectal Neoplasms; Central Nervous System Lymphoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Meningioma; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Glioma; Endometrial Neoplasms; Adenomatous Polyps; Gliosarcoma; Diffuse Intrinsic Pontine Glioma; Adenomatous Polyposis Coli; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Mantle-Cell; Breast Neoplasms; Multiple Myeloma; Neoplasms; Myelodysplastic Syndromes; Triple Negative Breast Neoplasms; Thalamic Diseases; Glioblastoma; Diffuse midline glioma; Solid tumours Details

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