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DLL4

概要

Name:Delta-like protein 4
Target Synonym:Delta-Like Protein 4,Notch Ligand Delta-2,DLL4,Delta4,Delta-Like 4 (Drosophila),Delta-Like 4 Homolog (Drosophila),AOS6,Hdelta2,Notch Ligand DLL4,Delta Like Canonical Notch Ligand 4,Delta 4,Delta Ligand 4,Delta-Like 4 Protein,Drosophila Delta Homolog 4,Delta-Like 4 Homolog
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 3 Clinical

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製造番号 種類 製品説明 構造 純度 特徴
MBS-C038 0 CytoPak ActiveMax® Human DLL4 μBeads, premium grade (for cells, 5.5μm)
GMP-DL4H27 Human GMP Human DLL4 Protein, Fc Tag (Flagship)
GMP-DL4H27-structure
GMP-DL4H27-sds
DL4-H82F7 Human Biotinylated Human DLL4 Protein, Fc,Avitag™, premium grade
DL4-H82F7-structure
DL4-H82F7-sds
MBS-C024 0 ActiveMax® DLL4 μBeads, premium grade (for cells, 20 μm)
DL4-H5255 Human Human DLL4 Protein, Fc Tag, premium grade (Flagship)
DL4-H5255-structure
DL4-H5255-sds
RES-A022 Human resDetect™ Biotinylated Human DLL4 ELISA Kit (Residue Testing)
RES-A052 Human resDetect™ Human DLL4 ELISA Kit (Residue Testing)
GMP-DL4H28 Human GMP Human DLL4 Protein, Fc Tag
GMP-DL4H28-structure
GMP-DL4H28-sds
GMP-DL4H23 Human GMP Biotinylated Human DLL4 Protein, His,Avitag™
GMP-DL4H23-structure
GMP-DL4H23-sds
MBS-C013 Human ActiveMax® Human DLL4 μBeads, premium grade (for cells)
CEA-B038 Human ClinMax™ Human Soluble Delta Like Protein 4 (DLL4) ELISA Kit, PRO
DL4-H82E6 Human Biotinylated Human DLL4 Protein, His,Avitag™, premium grade
DL4-H82E6-structure
DL4-H82E6-sds
DL4-H5227 Human Human DLL4 Protein, His Tag, low Endotoxin (MALS verified)
DL4-H5227-structure
DL4-H5227-sds
DL4-H5259 Human Human DLL4 Protein, Fc Tag, low endotoxin (MALS & SPR verified)
DL4-H5259-structure
DL4-H5259-sds
ACRO Quality

生物活性データの一部

MBS-C038-Cell-based assay
DLL4 FACS

Assay of human DLL4 protein on the μBeads surface by Flow cytomtry. CytoPak ActiveMax® Human DLL4 μBeads, Premium Grade (for cells, 5.5 μm) (Cat. No. MBS-C038) were stained with PE labeled anti-human DLL4 antibody and analyzed by flow cytometry.

Protocol
MBS-C024-Cell-based assay
DLL4 FACS

Assay of human DLL4 protein on the μBeads surface by Flow cytometry. Add 100ul of 1:80 Anti-DLL4 Antibody/PE-anti-Mouse IgG1 dilution into 5e5 of ActiveMax® Human DLL4 μBeads, premium grade (for cells, 20 μm)(Cat. No. MBS-C024), negative control as well. PE signals was used to evaluate DLL4 beads activity (QC tested).

Protocol
GMP-DL4H27-SPR
DLL4 SPR

GMP Human DLL4 Protein, Fc Tag (Flagship) (Cat. No. GMP-DL4H27) captured on Protein A Chip can bind Human NOTCH1 Protein, His Tag, premium grade (Cat. No. NO1-H52H3) with an affinity constant between 1.00 nM - 150 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
DL4-H5255-SPR
DLL4 SPR

Human DLL4 Protein, Fc Tag, premium grade (Flagship) (Cat. No. DL4-H5255) captured on Protein A Chip can bind Human NOTCH1 Protein, His Tag, premium grade (Cat. No. NO1-H52H3) with an affinity constant between 1.00 nM - 150 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol

カスタマーレビュー

Synonym Name

DLL4,Delta4

Background

Delta-like protein 4 (DLL4) is also known as Drosophila Delta homolog 4 (Delta4), which contains one DSL domain and eight EGF-like domains. DLL4 is expressed in vascular endothelium. DLL4 is involved in the Notch signaling pathway as Notch ligand, which can activates NOTCH1 and NOTCH4. DLL4 is involved in angiogenesis and negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. DLL4 can bind to Notch-1 and Notch-4.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
TR-009 NOV-1501; ABL001-ABL Bio; CTX-009; HD-B001A; ABL-001-ABL Bio; HDB001A; TR-009; ES-104 Phase 3 Clinical Abl Bio Inc Biliary Tract Neoplasms; Solid tumours; Rectal Neoplasms; Colonic Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Bile Duct Neoplasms; Ampullary Carcinoma; Gallbladder Neoplasms Details
Navicixizumab OMP-305B83 Phase 3 Clinical Oncomed Pharmaceuticals Inc Ovarian Neoplasms; Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms; Peritoneal Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms Details
Dilpacimab ABT-165; DVD-Ig ABT-165 Phase 1 Clinical Abbvie Inc Solid tumours; Neoplasms Details

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