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ENPP-2

概要

Name:Ectonucleotide pyrophosphatase/phosphodiesterase 2
Target Synonym:EC:3.1.4.39,ATX,Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2,Phosphodiesterase I/Nucleotide Pyrophosphatase 2,Plasma Lysophospholipase D,Autotaxin-T,EC 3.1.4.39,PD-IALPHA,ATX-X,NPP2,E-NPP 2,Autotaxin,ENPP2,PDNP2,Ectonucleotide Pyrophosphatase/Phosphodiesterase 2,Extracellular Lysophospholipase D,LysoPLD
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:6
Lastest Research Phase:Phase 2 Clinical

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製造番号 種類 製品説明 構造 純度 特徴
EN2-H5241 Human Human ENPP-2 / Autotaxin Protein, His Tag (active enzyme)
EN2-H5241-structure
EN2-H5241-sds
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Synonym Name

ENPP2,E-NPP 2,Autotaxin,LysoPLD,ATX,PDNP2,ATX-X,NPP2,PD-IALPHA

Background

Autotaxin also known as ectonucleotide pyrophosphatase / phosphodiesterase family member 2 (E-NPP 2 or ENPP2), Extracellular lysophospholipase D (LysoPLD), Autotaxin (ATX or ATX-X), which belongs to the nucleotide pyrophosphatase / phosphodiesterase family. ENPP2 contains two SMB (somatomedin-B) domains. ENPP2 hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. ENPP2 can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. ENPP2 stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
BBT-877 BBT-877 Phase 2 Clinical Legochem Idiopathic Pulmonary Fibrosis Details
Cudetaxestat PAT-409; BLD-0409 Phase 2 Clinical Blade Therapeutics Inc Metabolic Dysfunction-Associated Steatotic Liver Disease; Idiopathic Pulmonary Fibrosis; Liver Diseases Details
Cambritaxestat IOA-289 Phase 2 Clinical Merck & Co, Cancer Research Technology Solid tumours; Pancreatic Neoplasms Details
Ziritaxestat GLPG-1690 Phase 2 Clinical Galapagos Nv Idiopathic Pulmonary Fibrosis; Scleroderma, Systemic Details
HNC664 HNC664; HNC-664 Phase 1 Clinical Guangzhou Henovcom Bioscience Co Ltd Pancreatic Neoplasms; Idiopathic Pulmonary Fibrosis Details
HNC-1058 HNC-1058 Phase 1 Clinical Guangzhou Henovcom Bioscience Co Ltd Idiopathic Pulmonary Fibrosis Details
BBT-877 BBT-877 Phase 2 Clinical Legochem Idiopathic Pulmonary Fibrosis Details
Cudetaxestat PAT-409; BLD-0409 Phase 2 Clinical Blade Therapeutics Inc Metabolic Dysfunction-Associated Steatotic Liver Disease; Idiopathic Pulmonary Fibrosis; Liver Diseases Details
Cambritaxestat IOA-289 Phase 2 Clinical Merck & Co, Cancer Research Technology Solid tumours; Pancreatic Neoplasms Details
Ziritaxestat GLPG-1690 Phase 2 Clinical Galapagos Nv Idiopathic Pulmonary Fibrosis; Scleroderma, Systemic Details
HNC664 HNC664; HNC-664 Phase 1 Clinical Guangzhou Henovcom Bioscience Co Ltd Pancreatic Neoplasms; Idiopathic Pulmonary Fibrosis Details
HNC-1058 HNC-1058 Phase 1 Clinical Guangzhou Henovcom Bioscience Co Ltd Idiopathic Pulmonary Fibrosis Details

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