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Expression analysis of human IGF-1 R on Human IGF-1 R (Luc) HEK293 Reporter Cell by FACS.
Cell surface staining was performed on Human IGF-1 R (Luc) HEK293 Reporter Cell or negative control cell using PE-labeled anti-human IGF-1 R antibody.
Expression analysis of human IGF-1 R on NIH-3T3/Human IGF-1 R Stable Cell Line by FACS.
Cell surface staining was performed on NIH-3T3/Human IGF-1 R Stable Cell Line or negative control cell using PE-labeled anti-human IGF-1 R antibody.
Biotinylated Human IGF-I R, His,Avitag (Cat. No. IGR-H82E3) immobilized on CM5 Chip can bind Human IGF-I, His Tag (Cat. No. IG1-H5245) with an affinity constant of 33.9 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
---|---|---|---|---|---|---|---|---|---|---|
IGF-1 (Biogen/Pharmacia & Upjohn) | Approved | Biogen Inc, Pharmacia & Upjohn | Igef | Sweden | Dwarfism | null | 1994-01-01 | Dwarfism | Details | |
Brigatinib | AP-26113 | Approved | Ariad Pharmaceuticals Inc | Alunbrig, ALUNBRIG | United States | Carcinoma, Non-Small-Cell Lung | Takeda Pharmaceuticals U.S.A. Inc | 2017-04-28 | Solid tumours; Ependymoma; Carcinoma; Neoplasms; Neurofibromatosis 2; Myofibroma; Lung Neoplasms; Brain metastases; Granuloma, Plasma Cell; Lymphoma, Large-Cell, Anaplastic; Carcinoma, Non-Small-Cell Lung; Sarcoma, Kaposi; Neuroma, Acoustic; Meningioma; Neurilemmoma | Details |
Mecasermin (Astellas/OrphanPacific) | Approved | Astellas Pharma Inc | Somazon | Japan | Growth hormone deficiency; Dwarfism; Diabetes Mellitus, Lipoatrophic | null | 1994-10-05 | HIV Infections; Diabetes Mellitus, Lipoatrophic; Heart Failure; Myocardial Infarction; Multiple Sclerosis; Lipodystrophy; Dwarfism; Growth hormone deficiency | Details | |
Mecasermin (Ipsen) | IGF-1; FK-780; MKN-031 | Approved | Ipsen | Increlex | United States | Failure to Thrive | Ipsen Inc | 2005-08-30 | Failure to Thrive; Autism Spectrum Disorder; X-Linked Combined Immunodeficiency Diseases; Phelan-McDermid syndrome; Growth Disorders; Muscular Dystrophy, Duchenne; Laron Syndrome | Details |
Teprotumumab | R-1507; RG-1507; RO-4858696; HZN-001 | Approved | Genmab A/S, F. Hoffmann-La Roche Ltd | Tepezza | United States | Graves Ophthalmopathy | Horizon Therapeutics Ireland | 2020-01-21 | Neoplasms; Graves Ophthalmopathy; Sarcoma; Diabetic macular oedema; Breast Neoplasms; Scleroderma, Diffuse; Carcinoma, Non-Small-Cell Lung | Details |
Ceritinib | LDK-378; NVP-LDK378; NVP-LDK378-NX | Approved | Novartis Pharma Ag | 赞可达, Zykadia | EU | Carcinoma, Non-Small-Cell Lung | Novartis Europharm Ltd | 2014-04-29 | Colorectal Neoplasms; Melanoma; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Thyroid Neoplasms; Brain metastases; Esophageal adenocarcinoma; Granuloma, Plasma Cell; Lymphoma, Large-Cell, Anaplastic; Hematologic Neoplasms; Hepatic Insufficiency; Cholangiocarcinoma; Pancreatic Neoplasms; Thyroid Carcinoma, Anaplastic; Neoplasms; Glioblastoma; Stomach Neoplasms | Details |
Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
---|---|---|---|---|---|
MHB018A | Phase 2 Clinical | Minghui Pharmaceutical (Hangzhou) Co Ltd | Graves Ophthalmopathy | Details | |
Mecasermin Rinfabate | OHB-607; SHP-607; HGT-ROP-001; rhIGF-I/rhIGFBP-3; TAK-607 | Phase 2 Clinical | Insmed | Noonan Syndrome; Failure to Thrive; Cerebral Intraventricular Hemorrhage; Bronchopulmonary Dysplasia; Myotonic Dystrophy; Retinopathy of Prematurity; Muscular Dystrophies; Laron Syndrome | Details |
FPI-1434 | [225Ac]-FPI-1434; FPX-01 | Phase 2 Clinical | Fusion Pharma | Ovarian Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Neoplasms; Adrenocortical Carcinoma; Uveal melanoma; Breast Neoplasms; Endometrial Neoplasms; Uterine Cervical Neoplasms | Details |
VRDN-003 | VRDN-003 | Phase 1 Clinical | Viridian Therapeutics Inc | Graves Ophthalmopathy | Details |
Conteltinib | CT-707; SY-707 | Phase 3 Clinical | Shouyao Holding (Beijing) Co Ltd, Beijing Centaurus Biopharma Co Ltd | Pancreatic Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
Veligrotug | VRDN-001; ZB-001; AVE-1642 | Phase 3 Clinical | Viridian Therapeutics Inc | Solid tumours; Graves Ophthalmopathy; Multiple Myeloma; Breast Neoplasms | Details |
NNC0268-0965 | NNC0268-0965 | Phase 1 Clinical | Novo Nordisk A/S | Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | Details |
Picropodophyllin | PPP; AXL-1717; NSC-36407 | Phase 2 Clinical | Axelar Ab | Astrocytoma; Carcinoma, Non-Small-Cell Lung | Details |
ABL-301 | ABL-301 | Phase 1 Clinical | Abl Bio Inc | Parkinson Disease | Details |
Dalotuzumab | h7C-10; MK-0646; F-50-035 | Phase 2 Clinical | Pierre Fabre Group | Solid tumours; Rectal Neoplasms; Pancreatic Neoplasms; Neoplasms; Neuroendocrine Tumors; Multiple Myeloma; Breast Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung | Details |
VRDN-002 | VRDN-002 | Phase 1 Clinical | Viridian Therapeutics Inc | Graves Ophthalmopathy | Details |
Ganitumab | AMG-479 | Phase 3 Clinical | Amgen Inc | Breast Neoplasms; Neuroectodermal Tumors, Primitive, Peripheral; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Gastrointestinal Neoplasms; Lymphoma; Rhabdomyosarcoma, Alveolar; Lung Neoplasms; Colorectal Neoplasms; Neuroectodermal Tumors, Primitive; Prostatic Neoplasms; Sarcoma, Ewing; Sarcoma; Bone metastases; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Neoplasms; Colonic Neoplasms; Rectal Neoplasms; Carcinoid Tumor; Rhabdomyosarcoma, Embryonal; Ovarian Neoplasms; Rhabdomyosarcoma; Solid tumours; Intestinal Neoplasms | Details |
124I-CPD-1023-figitumumab | 124I-CPD-1028; 125I-CPD-1028; CPD-1028-[124I]; CPD-1028-[125I]; FPX-1028 | Phase 1 Clinical | Fusion Pharma | Neoplasms | Details |
Teprotumumab biosimilar(Innovent) | IBI-311 | Phase 3 Clinical | Innovent Biologics(Suzhou) Co Ltd | Graves Ophthalmopathy | Details |
CT-102 | CT-102 | Phase 2 Clinical | Hangzhou Tianlong Pharmaceutical Co Ltd, Institute Of Radiation And Radiation Medicine, Chinese Academy Of Military Medical Sciences | Liver Neoplasms; Carcinoma, Hepatocellular | Details |
Lonigutamab | VB-421 | Phase 2 Clinical | Pierre Fabre Group | Graves Ophthalmopathy | Details |
lonigutamab ugodotin | W-0101 | Phase 2 Clinical | Pierre Fabre Group | Solid tumours | Details |
Linsitinib | OSI-906; ASP-7487; OSI-906AA | Phase 3 Clinical | Astellas Pharma Inc, National Cancer Institute | Multiple Myeloma; Paraganglioma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Orbital Diseases; Eye Diseases; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Exophthalmos; Breast Neoplasms; Prostatic Neoplasms; Sarcoma, Ewing; Adrenocortical Carcinoma; Thyroid Diseases; Graves Ophthalmopathy; Endocrine System Diseases; Skin Neoplasms; Neoplasms; Small Cell Lung Carcinoma; Pancreatic Neoplasms; Hashimoto Disease; Head and Neck Neoplasms; Ovarian Neoplasms; Carney Complex; Liver Neoplasms; Solid tumours; Chondrosarcoma | Details |
IGF-1 receptor oligodeoxynucleotide-based immunotherapy (Thomas Jefferson University) | Phase 1 Clinical | Sidney Kimmel Cancer Center | Glioma | Details | |
Insulin-Like Growth Factor 1 (Wright State Physicians) | Phase 1 Clinical | Wright State Physicians | Nasolabial fold wrinkles; Burns; Sunburn | Details | |
Cixutumumab | A-12; IMC-A12; LY-3012217; NSC-742460 | Phase 2 Clinical | Eli Lilly And Company | Neuroblastoma; Colorectal Neoplasms; Gliosarcoma; Adenocarcinoma, Bronchiolo-Alveolar; Chondrosarcoma, Extraskeletal Myxoid; Lymphoma, Mantle-Cell; Neurofibrosarcoma; Gastrinoma; Medullary thyroid cancer (MTC); Brain Stem Neoplasms; Breast Neoplasms; Sarcoma; Retinoblastoma; Sarcoma, Ewing; Prostatic Neoplasms; Osteosarcoma; Glucagonoma; Glioma; Carcinoma, Hepatocellular; Neuroectodermal Tumors, Primitive, Peripheral; Paraganglioma; Melanoma; Adenocarcinoma; Breast Neoplasms, Male; Carcinoma, Non-Small-Cell Lung; Sarcoma, Alveolar Soft Part; Sarcoma, Synovial; Esophageal adenocarcinoma; Lung Neoplasms; Rhabdomyosarcoma, Alveolar; Esophageal Squamous Cell Carcinoma; Carcinoma, Neuroendocrine; Hemangiopericytoma; Pinealoma; Hemangiosarcoma; Carcinoma; Rhabdomyosarcoma, Embryonal; Desmoplastic Small Round Cell Tumor; Mesenchymoma; Hepatoblastoma; Stomach Neoplasms; Esophageal Neoplasms; Insulinoma; Rectal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Head and Neck Neoplasms; Kidney Neoplasms; Solid tumour | Details |
PHP-1003 | PHP-1003; PHP1003 | Phase 1 Clinical | Suzhou Pulekang Pharmaceutical Technology Co Ltd | Graves Ophthalmopathy | Details |
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