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gp130

概要

Name:Interleukin-6 receptor subunit beta
Target Synonym:IL6ST,Oncostatin-M Receptor Subunit Alpha,CD130,Interleukin-6 Signal Transducer,Interleukin-6 Receptor Subunit Beta,Gp130 Of The Rheumatoid Arthritis Antigenic Peptide-Bearing Soluble Form,CD130 Antigen,Membrane Glycoprotein Gp130,SGP130,IL-6R-Beta,HIES4,Gp130, Oncostatin M Receptor,IL-6RB,GP130,Cytokine Receptor gp130,Interleukin 6 Signal Transducer,Membrane Glycoprotein 130,Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor),CDW130,IL-6 Receptor Subunit Beta,Interleukin Receptor Bet
Number of Launched Drugs:6
Number of Drugs in Clinical Trials:12
Lastest Research Phase:Approved

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製造番号 種類 製品説明 構造 純度 特徴
ILT-M5252 Mouse Mouse gp130 / CD130 / IL-6 R beta Protein, Fc Tag
ILT-M5252-structure
ILT-M5252-sds
ILT-M52H1 Mouse Mouse gp130 / CD130 / IL-6 R beta Protein, His Tag
ILT-M52H1-structure
ILT-M52H1-sds
ACRO Quality

Synonym Name

IL6ST,gp130,CD130,IL-6RB,IL-6R-beta,CDw130

Background

Interleukin-6 receptor subunit beta (IL6ST) is also known as IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130 (gp130), CD130, Oncostatin-M receptor subunit alpha and Il6st,which is single-pass type I membrane protein. IL6ST /gp130 /CD130 can be found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver and found in all the cell lines tested except BaF-B03.The expression of IL-6ST /gp130 is not restricted to IL6-responsive cells. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. IL6ST /CD130 can bind to IL6 /IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduce the signal. IL6ST /GP130 does not bind IL6 and may have a role in embryonic development.

Clinical and Translational Updates

公開薬物情報

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Tocilizumab rhPM-1; RO-48775533; RG-1569; MRA; HPM-1; MRA-SC; R-1569 Approved Chugai Pharmaceutical Co Ltd Actemra, RoActemra, 雅美罗, Actemra/RoActemra, Acterma Japan Arthritis, Rheumatoid; Giant Cell Arteritis; Takayasu Arteritis; Cytokine Release Syndrome; Multicentric Castleman's Disease (MCD); Arthritis, Juvenile null 2005-04-11 Uveitis, Posterior; Polymyalgia Rheumatica; Takayasu Arteritis; Multicentric Castleman's Disease (MCD); systemic sclerosis-associated interstitial lung disease; Breast Neoplasms; Coronavirus Infections; Lupus Erythematosus, Systemic; Coronary Disease; Pulmonary Arterial Hypertension; Fever; Coronaviridae Infections; Lymphoma; Pleural Effusion, Malignant; Stroke; Inflammation; Rejection in heart transplantation; Pulmonary Disease, Chronic Obstructive; Uveitis; Osteoarthritis; Panuveitis; Non-ST Elevated Myocardial Infarction; Carcinoma, Hepatocellular; Anemia, Sickle Cell; Diabetes Mellitus; Behcet Syndrome; Amyotrophic Lateral Sclerosis; Kidney Failure, Chronic; Myocardial Infarction; Solid tumours; Non-radiographic axial spondyloarthritis; Cytokine Release Syndrome; HIV Infections; Acute Chest Syndrome; Diabetes Mellitus, Type 1; Craniopharyngioma; Motor Neuron Disease; Polymyositis; Schnitzler Syndrome; Giant Cell Arteritis; Uveitis, Intermediate; Pneumonia; Hematologic Neoplasms; Polyarticular Juvenile Idi Details
Tocilizumab biosimilar (Bio-Thera Solutions) BAT-1806; BIIB-800 Approved Bio-Thera Solutions Ltd 施瑞立, TOFIDENCE Mainland China Arthritis, Rheumatoid; Arthritis, Juvenile; Cytokine Release Syndrome Bio-Thera Solutions Ltd 2023-01-16 Cytokine Release Syndrome; Polyarticular Juvenile Idiopathic Arthritis; Arthritis, Rheumatoid; Arthritis, Juvenile Details
Satralizumab RG-6168; SA-237 Approved Chugai Pharmaceutical Co Ltd Enspryng, エンスプリング Japan Neuromyelitis Optica Chugai Pharmaceutical Co Ltd 2020-06-29 Myasthenia Gravis; Brain Ischemia; Graves Ophthalmopathy; Neuromyelitis Optica; Pulmonary Arterial Hypertension; Encephalitis; Subarachnoid Hemorrhage; Anti-N-Methyl-D-Aspartate Receptor Encephalitis Details
Sarilumab SAR-153191; REGN-88 Approved Sanofi Kevzara United States Arthritis, Rheumatoid Sanofi-Synthelabo 2017-05-22 Non-radiographic axial spondyloarthritis; Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19); Sarcoidosis; Mastocytosis, Systemic; Arthritis, Juvenile; Polymyalgia Rheumatica; Severe Acute Respiratory Syndrome; Uveitis Details
Tocilizumab biosimilar (Livzon Group) LZM-008 Approved Livzon Pharmaceutical Group Inc 安维泰 Mainland China Arthritis, Rheumatoid Livzon Mabpharm Inc 2023-01-18 Arthritis, Rheumatoid Details
Tocilizumab biosimilar (Fresenius kabi) MSB-11456 Approved Merck Serono Tyenne® EU Cytokine Release Syndrome; Arthritis, Rheumatoid; Giant Cell Arteritis; Coronavirus Disease 2019 (COVID-19) Fresenius Kabi Deutschland Gmbh 2023-09-15 Cytokine Release Syndrome; Giant Cell Arteritis; Polyarticular Juvenile Idiopathic Arthritis; Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19) Details
Tocilizumab rhPM-1; RO-48775533; RG-1569; MRA; HPM-1; MRA-SC; R-1569 Approved Chugai Pharmaceutical Co Ltd Actemra, RoActemra, 雅美罗, Actemra/RoActemra, Acterma Japan Arthritis, Rheumatoid; Giant Cell Arteritis; Takayasu Arteritis; Cytokine Release Syndrome; Multicentric Castleman's Disease (MCD); Arthritis, Juvenile null 2005-04-11 Uveitis, Posterior; Polymyalgia Rheumatica; Takayasu Arteritis; Multicentric Castleman's Disease (MCD); systemic sclerosis-associated interstitial lung disease; Breast Neoplasms; Coronavirus Infections; Lupus Erythematosus, Systemic; Coronary Disease; Pulmonary Arterial Hypertension; Fever; Coronaviridae Infections; Lymphoma; Pleural Effusion, Malignant; Stroke; Inflammation; Rejection in heart transplantation; Pulmonary Disease, Chronic Obstructive; Uveitis; Osteoarthritis; Panuveitis; Non-ST Elevated Myocardial Infarction; Carcinoma, Hepatocellular; Anemia, Sickle Cell; Diabetes Mellitus; Behcet Syndrome; Amyotrophic Lateral Sclerosis; Kidney Failure, Chronic; Myocardial Infarction; Solid tumours; Non-radiographic axial spondyloarthritis; Cytokine Release Syndrome; HIV Infections; Acute Chest Syndrome; Diabetes Mellitus, Type 1; Craniopharyngioma; Motor Neuron Disease; Polymyositis; Schnitzler Syndrome; Giant Cell Arteritis; Uveitis, Intermediate; Pneumonia; Hematologic Neoplasms; Polyarticular Juvenile Idi Details
Tocilizumab biosimilar (Bio-Thera Solutions) BAT-1806; BIIB-800 Approved Bio-Thera Solutions Ltd 施瑞立, TOFIDENCE Mainland China Arthritis, Rheumatoid; Arthritis, Juvenile; Cytokine Release Syndrome Bio-Thera Solutions Ltd 2023-01-16 Cytokine Release Syndrome; Polyarticular Juvenile Idiopathic Arthritis; Arthritis, Rheumatoid; Arthritis, Juvenile Details
Satralizumab RG-6168; SA-237 Approved Chugai Pharmaceutical Co Ltd Enspryng, エンスプリング Japan Neuromyelitis Optica Chugai Pharmaceutical Co Ltd 2020-06-29 Myasthenia Gravis; Brain Ischemia; Graves Ophthalmopathy; Neuromyelitis Optica; Pulmonary Arterial Hypertension; Encephalitis; Subarachnoid Hemorrhage; Anti-N-Methyl-D-Aspartate Receptor Encephalitis Details
Sarilumab SAR-153191; REGN-88 Approved Sanofi Kevzara United States Arthritis, Rheumatoid Sanofi-Synthelabo 2017-05-22 Non-radiographic axial spondyloarthritis; Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19); Sarcoidosis; Mastocytosis, Systemic; Arthritis, Juvenile; Polymyalgia Rheumatica; Severe Acute Respiratory Syndrome; Uveitis Details
Tocilizumab biosimilar (Livzon Group) LZM-008 Approved Livzon Pharmaceutical Group Inc 安维泰 Mainland China Arthritis, Rheumatoid Livzon Mabpharm Inc 2023-01-18 Arthritis, Rheumatoid Details
Tocilizumab biosimilar (Fresenius kabi) MSB-11456 Approved Merck Serono Tyenne® EU Cytokine Release Syndrome; Arthritis, Rheumatoid; Giant Cell Arteritis; Coronavirus Disease 2019 (COVID-19) Fresenius Kabi Deutschland Gmbh 2023-09-15 Cytokine Release Syndrome; Giant Cell Arteritis; Polyarticular Juvenile Idiopathic Arthritis; Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19) Details

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Recombinant humanized anti-IL-6R antibody (Hisun Pharma) HS-628 Phase 3 Clinical Zhejiang Hisun Pharmaceutical Co Ltd Arthritis, Rheumatoid; Arthritis Details
Tocilizumab biosimilar (AryoGen Pharmed) Phase 3 Clinical Aryogen Biopharma Arthritis, Rheumatoid Details
CMAB806 CMAB-806 Phase 3 Clinical Taizhou Maibo Taike Biotechnology Co Ltd Arthritis, Rheumatoid; Arthritis Details
Levilimab BCD-089 Phase 3 Clinical Biocad Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19) Details
Olamkicept FE-999301; CR-5/18; TJ-301; FE-301 Phase 2 Clinical Conaris Research Institute Colitis, Ulcerative Details
Atexakin alfa SON-080; r-IL-6 Phase 2 Clinical Weizmann Institute Of Science Peripheral Nervous System Diseases; Diabetic Neuropathies Details
VDJ-001 Phase 2 Clinical Beijing Vdjbio Co Ltd Arthritis, Rheumatoid; Multicentric Castleman's Disease (MCD) Details
Tocilizumab Biosimilar (qyuns) QX-003-S Phase 1 Clinical Qyuns Therapeutics Co Ltd Arthritis, Rheumatoid Details
Recombinant humanized anti-IL-6R antibody (Hisun Pharma) HS-628 Phase 3 Clinical Zhejiang Hisun Pharmaceutical Co Ltd Arthritis, Rheumatoid; Arthritis Details
Tocilizumab biosimilar (AryoGen Pharmed) Phase 3 Clinical Aryogen Biopharma Arthritis, Rheumatoid Details
CMAB806 CMAB-806 Phase 3 Clinical Taizhou Maibo Taike Biotechnology Co Ltd Arthritis, Rheumatoid; Arthritis Details
Levilimab BCD-089 Phase 3 Clinical Biocad Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19) Details
Olamkicept FE-999301; CR-5/18; TJ-301; FE-301 Phase 2 Clinical Conaris Research Institute Colitis, Ulcerative Details
Atexakin alfa SON-080; r-IL-6 Phase 2 Clinical Weizmann Institute Of Science Peripheral Nervous System Diseases; Diabetic Neuropathies Details
VDJ-001 Phase 2 Clinical Beijing Vdjbio Co Ltd Arthritis, Rheumatoid; Multicentric Castleman's Disease (MCD) Details
Tocilizumab Biosimilar (qyuns) QX-003-S Phase 1 Clinical Qyuns Therapeutics Co Ltd Arthritis, Rheumatoid Details

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