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Your Position: ホーム > IL-7

IL-7

概要

Name:Interleukin-7
Target Synonym:Interleukin 7,IL7
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 1 Clinical

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製造番号 種類 製品説明 構造 純度 特徴
GMP-L07H24GB01 Human CytoPak™ GMP Human IL-7 Protein
GMP-L07H24GB01-structure
IL7-H5116 Human Human IL-7 Protein (E. coli), premium grade
IL7-H5116-structure
IL7-H5116-sds
RES-A055 Human resDetect™ Human Interleukin-7 (IL-7) ELISA Kit (Residue Testing)
IL7-Y84 Mouse Mouse IL-7 Antibody, Mouse IgG1 (4C9F12)
IL7-Y84-sds
IL7-M52H3 Mouse Mouse IL-7 Protein, His Tag
IL7-M52H3-structure
IL7-M52H3-sds
GMP-L07H24 Human GMP Human IL-7 Protein
GMP-L07H24-structure
GMP-L07H24-sds
IL7-H5253 Human Human IL-7 Protein, Fc Tag (MALS verified)
IL7-H5253-structure
IL7-H5253-sds
IL7-H4219 Human Human IL-7 Protein, premium grade
IL7-H4219-structure
IL7-H4219-sds
ACRO Quality

生物活性データの一部

IL7-H5116-Cell-based assay
IL-7 CELL

Human IL-7 Protein (E. coli), premium grade (Cat. No. IL7-H5116) stimulates proliferation of PHA-P-activated human peripheral blood mononuclear cell (PBMC). The specific activity of Human IL-7 Protein (E. coli), premium grade > 1.00ⅹ10^8 IU/mg, which is calibrated against human IL-7 WHO International Standard (NIBSC code: 90/530) (QC tested).

Protocol
GMP-L07H24-Cell-based assay
IL-7 CELL

GMP Human IL-7 Protein (Cat. No. GMP-L07H24) stimulates proliferation of PHA-P-activated human peripheral blood mononuclear cell (PBMC). The specific activity of GMP Human IL-7 is > 1.00×10^8 IU/mg, which is calibrated against human IL-7 WHO International Standard (NIBSC code: 90/530) (QC tested).

Protocol
IL7-Y84-SPR
IL-7 SPR

Mouse IL-7 Antibody, Mouse IgG1 (4C9F12) (Cat. No. IL7-Y84) immobilized on CM5 Chip can bind Human IL-7, premium grade (Cat. No. IL7-H4219) with an affinity constant of 2.83 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
IL7-M52H3-ELISA
IL-7 ELISA

Immobilized Mouse IL-7 Protein, His Tag (Cat. No. IL7-M52H3) at 2 μg/mL (100 μL/well) can bind Human IL-7 R alpha, Mouse IgG2a Fc Tag (Cat. No. IL7-H5258) with a linear range of 0.2-2 ng/mL (QC tested).

Protocol

カスタマーレビュー

Synonym Name

IL7,Interleukin-7

Background

Interleukin 7 is also known as IL7, IL-7, and is a hematopoietic growth factor secreted by stromal cells in the red marrow and thymus. It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells, but is not produced by lymphocytes. IL-7 stimulates the differentiation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells, It also stimulates proliferation of all cells in the lymphoid lineage (B cells, T cells and NK cells). It is important for proliferation during certain stages of B-cell maturation, T and NK cell survival, development and homeostasis. IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL-7 binds to the IL-7 receptor, a heterodimer consisting of Interleukin-7 receptor alpha and common gamma chain receptor. Il-7 promotes hematological malignacies (acute lymphoblastic leukemia, T cell lymphoma). Elevated levels of IL-7 have also been detected in the plasma of HIV-infected patients. IL-7 as an immunotherapy agent has been examined in many pre-clinical animal studies and more recently in human clinical trials for various malignancies and during HIV infection. IL-7 could also be beneficial in improving immune recovery after allogenic stem cell transplant.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Anti-GPC3 chimeric antigen receptor T cell therapy (Hunan Zhaotai Yongren Biotech/Guangdong Zhaotai Invivo Biomedicine) Phase 1 Clinical Hunan Zhaotai Yongren Biotech Co Ltd, Guangdong Zhaotai Invivo Biomedicine Co Ltd Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung Details
ADP-TILIL7 ADP-TILIL7 Phase 1 Clinical Adaptimmune Therapeutics Plc Melanoma Details
GSK-3888130-B GSK3888130B; GSK-3888130; GSK-3888130-B Phase 1 Clinical Glaxosmithkline Plc Multiple Sclerosis Details
BNT-152 BNT-152 Phase 1 Clinical Biontech Se Solid tumours Details

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